A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive M/EEG field patterns arising from activity in subcortical and cortical sources under physiologically relevant sparse constraints is disclosed. The method includes a sparse inverse solution for M/EEG subcortical source modeling. Specifically, the method employs a subspace-pursuit algorithm rooted in compressive sampling theory, performs a hierarchical search for sparse subcortical and cortical sources underlying the measurement, and estimates millisecond-scale currents in these sources to explain the data. The method can be used to recover thalamic and brainstem contributions to non-invasive M/EEG data, and to enable non-invasive study of fast timescale dynamical and network phenomena involving widespread regions across the human brain.

A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive M/EEG field patterns arising from activity in subcortical and cortical sources under physiologically relevant sparse constraints is disclosed. The method includes a sparse inverse solution for M/EEG subcortical source modeling. Specifically, the method employs a subspace-pursuit algorithm rooted in compressive sampling theory, performs a hierarchical search for sparse subcortical and cortical sources underlying the measurement, and estimates millisecond-scale currents in these sources to explain the data. The method can be used to recover thalamic and brainstem contributions to non-invasive M/EEG data, and to enable non-invasive study of fast timescale dynamical and network phenomena involving widespread regions across the human brain.

A method implemented using at least one processor includes receiving a target image and a reference image. The target image is a distorted magnetic resonance image and the reference image is an undistorted magnetic resonance image. The method further includes selecting an image registration method for registering the target image to the reference image, wherein the image registration method uses an image transformation. The method further includes performing image registration of the target image with the reference image, wherein the image registration provides a plurality of optimized parameters of the image transformation. The method also includes generating a corrected image based on the target image and the plurality of optimized parameters of the image transformation.

System and method for non-contact acquisition of current physiological data representing a subject. A first electromagnetic wave representing current physiological status of a first subject is modified by a second electromagnetic wave representing current physiological status of a second subject in proximity to the first subject. A parameter of the first electromagnetic wave representing a first physiological status of a first subject is measured with electronic circuitry to extract a parameter of the second electromagnetic wave. Historical physiological data associated with the second subject is acquired. The current physiological data representing current physiological status of the second subject is then derived based on historical physiological data of the second subject and a comparison between the first and second parameters.