A method and apparatus (1) for monitoring particles flowing in a stack are disclosed. The method comprises emitting light from a light source along an optical path for scattering from the particles, rotating a rotatable monitoring assembly (15) mounted in the optical path, and detecting the scattered light using a detector. The rotatable monitoring assembly (15) contains at least two in apertures, and the method further comprises rotating the rotatable monitoring assembly (15) into a plurality of different configurations. In an operation configuration, light passes through the rotatable monitoring assembly (15) and into the stack unimpeded. In a zero-check configuration, the rotatable monitoring assembly (15) blocks the light from reaching the stack. In a span-check configuration, light of varying intensity passes from the light source through the rotatable monitoring assembly (15) into the stack. In a contamination-check configuration, the light is reflected through the rotatable monitoring assembly (15) onto the detector, without entering the stack. In the safety-shutter configuration, the rotatable monitoring assembly (15) protects optical components in the instrument from particles in the stack.

Embodiments of the invention are directed to an optoelectronic device for detection and identification of individual water droplets, ice crystals, dust particles and volcanic ash particles, the device comprising a source of ultraviolet collimated monochromatic radiation that illuminates an area of air external to the aircraft through which freely pass individual atmospheric particles to create an illuminated sample volume of air; an optical surveillance system for monitoring the clarity of light transmission through the light transmissive window to indicate a need for preventive maintenance; a first optical detection system that is constructed and arranged to collect light scattered from individual particles over an explicit angle ranging from 137° to 173° that defines the illuminated sample volume for measurement of S and P components of return scattered light from the sample volume to photodetectors that provide signals representative of intensity and change in polarization state caused by the interaction of particles with the incident illumination in the sample volume; a second optical detection system for selectively detecting fluorescence emanating from individual ash particles over an explicit angle ranging from 137° to 173° that defines the illuminated sample volume for measurement of fluoresence from the sample volume to a photodetector that provide a signal representative of intensity caused by the interaction of particles with the incident illumination in the sample volume; a signal processor that is constructed and arranged to condition the signals from the photodetectors by removing electronic noise, restoring baseline shifts and analyzing the pulse shapes to provide processed signals; a signal analyzer configured to operate upon the processed signals for extraction of data representing maximum amplitude, width, rise time and fall time of individual pulses in the S and P components, and the magnitude of the fluorescence signal which correlates to the size and/or composition of ash particles present; an information synthesizer that receives the data and produces analytical results allocated to particles by particle type including equivalent optical diameter (EOD), number and mass size distributions, and number and mass concentrations, the particle type being selected as at least one member among the group consisting of individual water droplets, ice crystals, dust particles and volcanic ash particles; and a report generator that creates an information packet utilizing information from the information synthesizer to assist in decision making related to hazard avoidance for aircraft flight, the optoelectronic system being adapted for mounting

Disclosed herein are systems and methods capable of identifying, tracking, and sorting particles or droplets flowing in a channel, for example, a microfluidic channel having a fluid medium. The channel and the fluid medium can have a similar refractive index such that they appear translucent or transparent when illuminated by electromagnetic radiation. The particles or droplets can have a refractive index substantially different from that of the channel and the medium, such that the particles or droplets interfere with the electromagnetic radiation. A sensor can be disposed adjacent to the channel to record the electromagnetic radiation. The sensor can be attached to a system for identifying, tracking, and sorting the droplets.

A dynamic impedance imaging system includes a dynamic impedance imaging sensor, an impedance detection and flow rate measurement module and an electrical impedance tomography (EIT) instrument. The impedance detection and flow rate measurement module is configured to detect an abnormal particle flowing through the dynamic impedance imaging sensor to obtain a flow rate of the abnormal particle, and generate a synchronous trigger signal. The EIT instrument is configured to inject a sinusoidal excitation current into the dynamic impedance imaging sensor under the trigger of the synchronous trigger signal, perform multi-channel interleaved sampled for the abnormal particle according to the flow rate to acquire multi-channel sampled data, and calibrate the multi-channel sampled data to implement impedance tomography imaging for the abnormal particle.

Even for the case where cells such as human epidermal keratinocytes form a dense colony, or the case where cell contours are indefinite, each of the cells is automatically tracked with high precision, and behavior of each cell is analyzed with good precision. There is provided a method for analyzing behavior of a cell, which comprises a detection step of detecting positions of a plurality of cells for every frame of time-lapse images, while determining whether a candidate region extracted from the frame is a cell region by using a dictionary containing image data of cell nuclei; and a tracking step of tracking each cell by using a state space model using position of a most adjacent cell within a predetermined distance from a predicted position as observation data. When any cell is not found within a certain distance from the predicted position, data are considered missing.

A process tube device can detect the presence of any external materials that may reside within a fluid flowing in the tube. The process tube device detects the external materials in-situ which obviates the need for a separate inspection device to inspect the surface of a wafer after applying fluid on the surface of the wafer. The process tube device utilizes at least two methods of detecting the presence of external materials. The first is the direct measurement method in which a light detecting sensor is used. The second is the indirect measurement method in which a sensor utilizing the principles of Doppler shift is used. Here, contrary to the first method that at least partially used reflected or refracted light, the second method uses a Doppler shift sensor to detect the presence of the external material by measuring the velocity of the fluid flowing in the tube.

A fractionated photoacoustic flow cytometry (PAFC) system and methods for the in vivo detection of target objects in biofluidic systems (e.g., blood, lymph, urine, or cerebrospinal fluid) of a living organism is described. The fractionated system includes a fractionated laser system, a fractionated optical system, a fractionated acoustic system, and combinations thereof. The fractionated laser system includes at least one laser or laser array for pulsing a target object within the circulatory vessel with fractionated focused laser beams. The fractionated optical system separates one or several laser beams into multiple beams in a spatial configuration on the skin above the circulatory vessel of the living organism. The fractionated acoustic system includes multiple focused ultrasound transducers for receiving photoacoustic signals emitted by the target object in response to the fractionated laser beams.

A particle sensor is described. The particle sensor includes a laser module having a laser, and a detector configured to detect thermal radiation. The particle sensor has an optical apparatus that is configured to focus laser light proceeding from the laser module into a first spot and is configured to focus thermal radiation proceeding from the first spot into a second spot, a radiation-sensitive surface of the detector being located in the second spot, or behind the second spot in the beam path of the thermal radiation focused onto the second spot.

The present technology relates to systems and associated methods for measuring properties of particles in a solution. In one or more embodiments, a particle measurement system is configured to generate a reference signal, communicate the reference signal across a plurality of resistors and overlapping pairs of electrodes that define detection regions for particulates traveling through a microchannel, and measure various properties of the particles based on detecting changes in the communicated reference signal.

The present invention relates to a method for cancer cell separation, and more specifically, relates to a method for cancer cell separation using micro-vibration.