The present invention relates to a method for sizing a microfluidic device for confining a sample. The sample to be confined can include cells (biological sample) or microparticles suspended in a carrier fluid medium. The present invention also relates to a method for sizing a microfluidic device for confining an explant contained in a cell culture fluid medium.

Provided is a technology that enables the shortening of the designing period. A device designing method includes a step of extracting a structure compatible with requested characteristics from a database in which each structure of a device is associated with characteristics and a step of outputting the extracted structure and a tuning parameter for adjusting the structure into ranges of the requested characteristics. In regard to each structure parameter determining the structure of the device, characteristics obtained by performing a simulation while exhaustively changing the structure parameter in a manufacturable range and the structure parameter used for the simulation are stored in the database while being associated with each other.

A micromechanical device and a corresponding manufacturing method. The micromechanical device includes: a spring element which is moveably coupleable or is moveably coupled to a frame unit at at least one connecting point of the spring element, the spring element including at least one web, which extends outward from the at least one connecting point; and the at least one web being structured in such a way that it includes at least one first section as well as at least one widening section for reducing a non-linearity of the spring element, which is widened compared to the first section.

A method of developing a physical design layout of microfluidic system chip can include receiving a planarized graph of a netlist including vertices representing microfluidic components. The vertices can be expanded into components, where each component includes a first dimension and a second dimension. The components can be shifted to a position where the first and second dimension of each component do not overlap with the first dimension and the second dimension of any other component. A flow route can be determined based on the first and second dimension of each component and the position of each component, the flow route including channels connecting two or more of the components.

A nano-electromechanical switch and a method for designing a nano-electromechanical switch. The nano-electromechanical switch includes at least one actuator electrode and a curved cantilever beam. The curved cantilever beam is adapted to flex in response to an activation voltage applied between the actuator electrode and the curved cantilever beam to provide an electrical contact between the curved cantilever beam and an output electrode of the nano-electromechanical switch. Before, during and after the curved cantilever beam flex in response to the activation voltage, a remaining gap between the curved cantilever beam and the actuator electrode is uniform.

The present disclosure describes diffractive optical elements (DOEs) and master tools for producing the DOEs. In one aspect, the disclosure describes a method that includes modifying a first pixel layout design for diffractive optical elements to obtain a modified pixel layout design. The first pixel layout design comprises pixels, each of which has a shape of a regular polygon (e.g., a rectangular shape). Modifying the first pixel layout design includes approximating a shape contour of a cluster of pixels in the first pixel layout design by a single polygon that reduces a total number of edges relative to the shape contour of the cluster of pixels in the first pixel layout design. The method also includes using the modified pixel layout design to form a master tool for production of the diffractive optical elements.