The present disclosure features a composition, including molecularly imprinted crosslinked polymers that have been imprinted with trimethylamine N-oxide. The molecularly imprinted crosslinked polymers have specific binding sites for trimethylamine N-oxide, and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g.

The present disclosure provides a preparation method of AM-type polystyrene microsphere ofloxacin imprinted polymer as well as an application thereof. A monomer acrylamide and an initiator ammonium persulfate are subjected to graft polymerization on the surface of modified polystyrene primary amine resin, to get grafted particles; then an adsorption test of a levofloxacin solution by the grafted particles PAM/PSA is conducted, and then a levofloxacin surface molecularly imprinted material MIP-PAM/PSA is prepared by using ethylene glycol diglycidyl ether as the crosslinking agent. The present disclosure can realize the separation and purification of racemic ofloxacin effectively, thus providing a new method and material for separating and enriching s-type ofloxacin in the industry. Because the antibacterial efficacy of S-ofloxacin on Gram-negative bacteria and positive bacteria is 8-128 times that of its enantiomer R-ofloxacin, so the present technology can improve the efficacy of a drug greatly.

The present disclosure relates to molecularly imprinted polymers that target cannabinoid(s), including THC and CBD, as well as methods of making molecularly imprinted polymers that target cannabinoid(s), including THC and CBD and uses thereof.

A colorimetric sensor for detecting an analyte of interest that includes a metal layer disposed upon a substrate, a plurality of nanostructures, and a corresponding plurality of metal deposits spaced apart from the metal layer. The metal layer defines a plurality of holes, each nanostructure includes a first portion disposed within a respective hole, and each metal deposit is disposed upon a second portion of a respective nanostructure. The sensor also includes a molecularly imprinted polymer layer that may cover the metal layer, the nanostructures, and/or the metal deposits. The molecularly imprinted polymer layer defines a cavity shaped to receive the analyte of interest, and the sensor is configured such that, when an analyte contacts the molecularly imprinted polymer layer and becomes disposed within the cavity, an optical property of at least a portion of the sensor changes thereby to cause a detectable color change in and/or from the sensor.

A molecularly imprinted polymer in the form of nanoparticles, a method of preparation and uses thereof. Polymeric nanoparticles have recognition sites of at least one target molecule and are obtained by crosslinking of at least one polymer that is functionalized at least with polymerizable double bonds, in a liquid and in the presence of at least one target molecule as template molecule. Polymeric nanoparticles can be used for many applications, such as selective recognition of analytes, in vivo and in vitro targeting, labelling of biological molecules or in the preparation of molecular sensors.

Systems and methods for the detection of one or more target molecules emitted from microbial sources are described. The systems and methods may include a molecularly imprinted polymer film; a strain sensitive surface, wherein the molecularly imprinted polymer film comprises a polymer host with one or more binding sites for one or more target molecules. The molecularly imprinted polymer film may be coated upon the strain sensitive surface.

A colorimetric sensor for detecting an analyte of interest that includes multiple surfaces and a molecularly imprinted polymer defining a cavity shaped to receive an analyte of interest. Each surface defines a void (e.g., a pore or a nanohole) and at least one surface defines a fluid inlet. The sensor is configured such that, when an analyte contacts the molecularly imprinted polymer and becomes disposed within the cavity, a wettability of at least one of the surfaces changes thereby to cause a detectable color change in the sensor. Optionally, the sensor may also include a metal layer at a bottom of each void or nanohole and outside a top of each void or nanohole for use as a plasmon resonance-type sensor.

Devices and methods for the detection of an analyte, e.g, from exhaled breath or air are provided. A sensor includes a polymer layer molecularly imprinted for the analyte, a metal layer, and an electrocatalytic layer disposed between the polymer layer and the metal layer. The electrocatalytic layer is functionalized with at least one chemical compound that provides for noncovalent interaction with the analyte. The sensor further includes electrodes in operative arrangement with the polymer layer and configured to provide a signal indicative of a resistance. A change in resistance of the device can indicate the presence of the analyte in the sample.

The present invention disclose a N,O-type multidentate functional monomer(AAPTS-COOH), a preparation method thereof and an application thereof in ion-imprinted polymers, and belongs to the technical field of separation materials. The N,O-type multidentate functional monomer of the present invention is obtained through the Michael addition reaction of N-aminoethyl-γ-aminopropyltrimethoxysilane and acrylic esters, bonding an ester group to the amino group and imine group of N-aminoethyl-γ-aminopropyltrimethoxysilane, and hydrolyzing the ester group with a trifluoroacetic acid solution. The 2 nitrogen atoms and 3 oxygen atoms in the functional monomer can coordinate with metal ions. The N,O-type multidentate functional monomer prepared by the present invention can be used to prepare an ion-imprinted polymer (IIP). The imprinted material has high selective adsorption capacity for copper ions and nickel ions. In addition, the IIP synthesis method based on AAPTS-COOH of the present invention has good universality.

The present disclosure provides Molecularly Imprinted Polymer (MIP) technology for selectively sequestering one or more target molecules from chemical mixtures. Also disclosed herein are MIP beads and methods of making and using thereof.