The present invention relates to the technical field of peroxide decomposition, and discloses a method for preparing phenol, which comprises the following steps: (1) mixing cumene hydroperoxide and liquid acid or solid acid with a solvent to form a homogeneous solution or uniformly dispersed system; (2) loading the homogeneous solution or uniformly dispersed system of cumene hydroperoxide with a homogeneous solution or uniformly dispersed system of acid into a preheating module and preheating in a micro-channel continuous flow mode, preliminarily mixing the preheated materials for reaction in a mixing module in a micro-channel continuous flow mode, and then further mixing the materials for reaction in a series of mixing and reaction module groups in a micro-channel continuous flow mode, to obtain phenol. The method provided in the present invention is easy, simple and safe to operate, can implement continuous production of phenol product at a high yield ratio; in addition, since the reaction in the present invention is a cracking reaction, which releases heat strongly, the safety factor of the process is significantly improved owing to the strong heat release characteristic in conjunction with the unique heat transfer property of the micro-channels. With the method provided in the present invention, the yield of the product is higher than 99%.

A flow reactor fluidic module (12) includes a reactant fluid module (20) having an internal process fluid passage (22) and a first major planar outer surface (24a) and a thermal resistance R between the internal process fluid passage (22) and the first major planar surface (24); a thermal control fluid module (30) having an internal thermal control fluid passage (32) and a second major planar outer surface (34a); a holding structure (50) holding the reactant fluid module (20) and the thermal control fluid module (30); and a gap (25) separating the first major planar surface (24a) from the second major planar surface (34a). The gap (25) comprises an interchangeable or replaceable substance or sheet (26) having a thermal resistance G across the gap (25), wherein G is not equal to R.

A flow reactor fluidic module (12) includes a reactant fluid module (20) having an internal process fluid passage (22) and a first major planar outer surface (24a) and a thermal resistance R between the internal process fluid passage (22) and the first major planar surface (24); a thermal control fluid module (30) having an internal thermal control fluid passage (32) and a second major planar outer surface (34a); a holding structure (50) holding the reactant fluid module (20) and the thermal control fluid module (30); and a gap (25) separating the first major planar surface (24a) from the second major planar surface (34a). The gap (25) comprises an interchangeable or replaceable substance or sheet (26) having a thermal resistance G across the gap (25), wherein G is not equal to R.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

A reservoir for one or more chemical reactants has means for heating the reactants and optional means for stirring the reactants. A pumped reactant feed line and a return line provide fluid communication between the reservoir and a 4-way valve system. The 4-way valve system is also in fluid communication with a reactor vessel and a source of inert gas for purging the system. In a first state, the 4-way valve provides fluid communication between the reservoir and the reactor. In a second state, the 4-way valve provides a continuous circulation path for the heated reactants from the reservoir, to the valve system, and back to the reservoir via the return line. In a third state, the 4-way valve provides a fluid pathway for purging the reactor with inert gas. In a fourth state, the 4-way valve provides a fluid pathway for purging the reservoir with inert gas.

A flow reactor has a module (12) that comprises at least first (20), second (30), and third (40) parallel plates stacked temporarily or permanently together and defining a first thermal fluid layer (25) between the first (20) and second plates (30) and a process fluid layer (35) between the second (30) and third plates (40), the process fluid layer (35) comprising a process fluid passage (32) having two or more U-bends and three or more successive process fluid passage segments joined by respective U-bends, the first thermal fluid layer (25) comprising at least two open thermal fluid channels (26) in the second plate (30), the at least two open channels (26) positioned, when viewed in a plan view of the module (12), between respective adjacent process fluid passage segments.

A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).

Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

The invention relates to a process for the preparation of Efavirenz via an efficient transition metal catalyzed cyclization, to a device suitable to perform such process as well as to novel intermediates.

A reservoir for one or more chemical reactants has means for heating the reactants and optional means for stirring the reactants. A pumped reactant feed line and a return line provide fluid communication between the reservoir and a 4-way valve system. The 4-way valve system is also in fluid communication with a reactor vessel and a source of inert gas for purging the system. In a first state, the 4-way valve provides fluid communication between the reservoir and the reactor. In a second state, the 4-way valve provides a continuous circulation path for the heated reactants from the reservoir, to the valve system, and back to the reservoir via the return line. In a third state, the 4-way valve provides a fluid pathway for purging the reactor with inert gas. In a fourth state, the 4-way valve provides a fluid pathway for purging the reservoir with inert gas.