A device for collecting multiple samples for use by a single user while avoiding cross-contamination under adverse conditions is disclosed. A multiple sampling device comprising a single handle actuator with a trigger, connected to a shaft assembly further connected to a claw assembly for actuating a self-sealing sampling sphere in the process of collecting a desired sample, is disclosed. The sampling sphere comprises two halves that separate when the trigger and claw assembly are actuated, and close together when the trigger is released using springs on the claw assembly and sampling sphere. Additional sampling spheres are stored on the shaft assembly. In operation, once a sample is collected by one sampling sphere, the sampling sphere is exchanged with an empty sampling sphere stored on the shaft assembly.

Lid configurations for thermal cyclers and uses thereof are provided. A nucleic acid amplification device may include a lid assembly that may be able to move between an open and closed configuration. The lid assembly may include a heater therein. The heater in the lid may have an adjustable configuration that may be able to accommodate different configurations of sample containers. Optionally, the heater may be retractable within a housing of the thermal cycler, when the lid is opened.

A test strip device including a housing, at least one retention arm, an ejection tab, and a viewing window. The housing includes a channel extending through the housing, with an opening at a first end of the housing, the channel being configured to receive a test strip therein. The at least one retention arm is arranged within the channel and configured to retain the test strip within the channel. The ejection tab is slideably arranged within the housing and configured to slide the test strip through the channel and out of the opening. The viewing window is arranged within the housing and configured to allow a results region of the test strip disposed within the channel to be viewed through the viewing window.

An exemplary embodiment of the present disclosure provides a fluidic device comprising a substrate, an applicator, and a spacer. The substrate can comprise a plurality of wells. The applicator can be used for manipulating a biological substance in at least a portion of the plurality of wells. The spacer can be positioned between the substrate and the applicator. The spacer can be configured to allow the applicator to apply the biological substance to at least a portion of the plurality of wells while maintaining a space between the substrate and the applicator.

A device for sealing a reagent container storing and providing liquids, in particular in an analyzer system. The invention also relates to a reagent container using such device for sealing, a cartridge for holding such reagent container, and a method for removing a liquid from such reagent container. The instant invention provides a device for sealing a reagent container comprising an annular member configured to be inserted into the reagent container, wherein the annular member is configured to being movably coupled to the reagent container relative to its longitudinal center axis; an opening passing from a top end of the annular member to a bottom end of the annular member; and a sealing element arranged between the top end and the bottom end of the annular member for sealing the opening.

The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preservation or storage of samples (e.g., biospecimen samples) by using one or more of a bridge, a membrane, and/or a desiccant.

Described herein are three-dimensional (3-D) paper fluidic devices. The entire 3-D device is fabricated on a support layer formed from a single sheet of material and assembled by folding the support layer. The folded structure may be enclosed in an impermeable cover or package. Chemically sensitive particles may be disposed in the support layer for use in detecting analytes.

The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.

A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.

A thermal cycler system for use with a sample holder configured to receive a plurality of samples includes a sample block configured to receive the sample holder, a cover lid configured to move in a direction toward the sample block from an open position to a closed position, a heated cover operatively coupled to the cover lid and configured to move in a direction toward the sample block from a raised position to a first lowered position, in which the heated cover contacts the sample holder when the sample holder is received by the sample block, and a drive assembly including a motion guide configured to move in a direction toward the sample block from a first position, wherein the cover lid is in the open position and the heated cover is in the raised position, to a second position, wherein the cover lid is in the closed position.