B01L2400/0478

SAMPLE SOLUTION CONCENTRATION METHOD AND SAMPLE SOLUTION EXAMINATION METHOD

There are provided a sample solution concentration method that makes it possible to obtain a sample solution concentrated solution having a desired concentration fold ratio and a sample solution examination method using the sample solution concentration method. The sample solution concentration method includes, in the following order, a sample solution injection step of injecting a sample solution, which is an aqueous solution containing a high-molecular-weight molecule, into a cylinder accommodating a particulate super absorbent polymer, a water absorption step in which water contained in the sample solution injected into the cylinder is absorbed by the super absorbent polymer accommodated in the cylinder to generate a sample solution concentrate which is a concentrate of the sample solution, in the cylinder, a liquid addition step of adding a liquid having an amount smaller than an amount of the sample solution injected into the cylinder in the sample solution injection step, to the sample solution concentrate, and a taking-out step of inserting, into the cylinder, a piston insertable into the cylinder, the piston including a tip part having holes smaller than a particle diameter of the super absorbent polymer after water absorption, to take out a sample solution concentrated solution, which is a concentrated solution of the sample solution, through the holes in the tip part of the piston.

Device for analysis of cellular motility

A mesoscale fluidic system comprises a substrate having a sample chamber and an analysis chamber. The sample chamber comprises a cell permeable filter defining a sample application compartment and a conditioning medium compartment. The sample chamber has a sample inlet port in the sample application compartment. The analysis chamber has an entry port and an exit port. The conditioning medium compartment is in fluid communication with the entry port of the analysis chamber via a channel. The sample application compartment is below the cell permeable filter and the conditioning medium compartment is above the cell permeable filter. The mesoscale fluidic system is suited for analysing cellular motility in a sample. Also disclosed is a method of estimating the quantity of motile cells in a sample and a method of extracting motile cells from non-motile cells.

Microfluidic chip and droplet separation method
11701659 · 2023-07-18 · ·

The present disclosure provides a microfluidic chip and a droplet separation method, and belongs to the field of biological chip technology. The microfluidic chip includes a first liquid tank and a second liquid tank opposite to each other and a channel layer therebetween. The channel layer includes a plurality of microfluidic channels separated from each other, first ends of the microfluidic channels are communicated with the first liquid tank, and second ends are communicated with the second liquid tank. The first liquid tank contains sample solution to be detected, and the second liquid tank contains encapsulating liquid. The sample solution to be detected entering the first liquid tank may be separated into a plurality of sample droplets through the microfluidic channels, the separated sample droplets enter the second liquid tank, so that the encapsulating liquid is encapsulated on a surface of each of the plurality of sample droplets.

Gene Detection Kit and Dene Detection Device

Provided are a gene detection kit and a gene detection device. The gene detection kit includes a kit body, a piston cylinder, and a piston. The kit body has an accommodating cavity and a plurality of reagent cavities. The piston cylinder is provided in the accommodating cavity, and the piston cylinder has a piston cavity. The piston is movably provided in the piston cavity along an axial direction of the piston cylinder. A first channel in communication with the piston cavity is provided on an outer circumferential surface of the piston cylinder, a plurality of second channels are provided on an inner wall of the accommodating cavity, each of the second channels is in corresponding communication with one of the reagent cavities, and the piston cylinder can move relative to the kit body, so that the plurality of second channels are alternately in communication with the first channel.

Method for dosing liquid by means of a pipette and a syringe, and pipette for actuating a syringe for dosing liquid
11697113 · 2023-07-11 · ·

A pipette with an adjustable dosing increment, wherein a control apparatus determines a dosing volume by a set dosing increment when a syringe is inserted in the pipette, and determines a maximum possible number of dosing steps following an execution of a reverse stroke without refilling the syringe given the set dosing increment and completely or partially filled syringe by the position of a displacement means on the path, and displays the maximum number of dosing steps on a display apparatus until the reverse stroke is executed. The control apparatus also determines the number of executed dosing steps and displays the number of executed dosing steps and/or the number of dosing steps still possible without refilling the syringe on the display apparatus.

TARGET MATERIAL EXTRACTION KIT FOR CENTRIFUGAL SEPARATOR, AND METHOD FOR EXTRACTING TARGET MATERIAL BY USING SAME
20230012405 · 2023-01-12 · ·

The present invention relates to a target material extraction kit for a centrifugal separator and a method for extracting a target material by using the target material extraction kit for a centrifugal separator, and more specifically, to a target material extraction kit for a centrifugal separator and a method for extracting a target material by using the target material extraction kit for a centrifugal separator by which the target material can be more easily extracted from a source material that is separated into layers by the centrifugal separator, and thus simplification of the extraction operation of the target material results in improvement in easiness and efficiency of the extraction operation.

Device and Method for Centrifuging a Physiological Fluid
20230010728 · 2023-01-12 ·

A device and associated method for centrifuging a physiological fluid includes a container including a tip, a base, and a barrel extending between the tip and the base to hold a physiological fluid. The container includes a plunger positioned within the barrel of the container. The plunger includes a concave collection surface that faces the tip of the container. A plunger gasket seal is in sealing engagement with an inside wall of the barrel of the container. A bottom support is provided to support the base of the container at least partially within the bottom support for use in a centrifuge. The container is coupled to the bottom support using an interference fit. The collection surface of the plunger and at least the barrel can be made of the same material. Advantageously, the device can be used to process blood without the need for any added anticoagulant in the blood.

PIPETTING DEVICE WITH GAS-SOUND-TRIGGERED DISPENSING OF FLUID AMOUNTS PREFERABLY IN THE RANGE OF 10 TO 500 NL
20230211334 · 2023-07-06 ·

A pipetting device for outputting amounts of a dosing fluid of less than 1 μl including a fluid volume; a pipetting plunger that can be moved along a plunger path, wherein a displacement of the pipetting plunger brings about a first pressure change in the fluid volume; a movement drive which is force-transmittingly connected to the pipetting plunger in order to drive the pipetting plunger such that it moves along the plunger path; a sound source which is designed to generate at least one sound impulse as a second pressure change in the fluid volume; and a control device which is designed to control the movement drive and the sound source, the pipetting device having a pipetting channel which extends along a channel axis and in which both the pipetting plunger is moveably accommodated along the channel axis as the plunger path and the fluid volume is accommodated, wherein the fluid volume includes a working gas which wets a plunger surface of the pipetting plunger, wherein, in addition, the sound source is designed and arranged to generate the at least one sound impulse in the working gas.

Dispenser for taking up and dispensing volumes of fluid and a method for mounting and releasing a piston-cylinder unit from the dispenser

A dispenser for receiving and dispensing volumes of fluid, on which a piston/cylinder unit having a piston and a cylinder, can be fitted in a releasable manner by means of a movement running at least substantially in an axial direction of the dispenser. The dispenser has a piston actuator for moving the piston relative to the cylinder. The piston actuator is arranged in a movable manner in the dispenser and is driven by means of a drive. The dispenser has a locking element which is arranged in a movable manner in the dispenser and is driven by a further drive. Also disclosed is a system for receiving and dispensing volumes of fluid, to a method for fitting a piston/cylinder unit in a releasable manner on a dispenser, and to a method for releasing a piston/cylinder unit which has been fitted on a dispenser.

Methods, devices, and apparatus for washing samples on array plates

An apparatus for washing an array plate includes one or more dispensers and one or more aspirators that are distinct from the one or more dispensers. A respective dispenser of the one or more dispensers is configured to dispense a first liquid on the array plate, and a respective aspirator of the one or more aspirators is configured to aspirate liquid on the array plate. A method for washing particles is also disclosed.