Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

A bladeless mixer for mixing a liquid, includes a cylindrical or truncated cone-shaped receptacle having an axis A and a radius R, the radius R being the shortest distance between the axis A and a side wall of the receptacle, the liquid to be mixed being placed in the receptacle and having an exposed surface at a height H measured along axis A; a member for tilting the receptacle such that axis A forms a non-zero-degree angle of up to 30° relative to the vertical direction; a member for imparting a rotational movement to the receptacle along axis A at an angular speed of rotation Ω; wherein the aspect ratio H/R of the height H to the radius R and the angular speed of rotation Ω are selected such that an inherent mode of inertia of the liquid has an unstable resonance when the receptacle is tilted and rotates.

Examples of containers for the production of a foamed sclerosant composition are provided. The containers include a container body comprising one or more sidewalls extending between a top and a bottom of the container body and a bottom surface, a foaming space being defined in an interior of the container body. The foaming space contains a sterile gas and a mixing element configured to be operatively coupled with a rotatable actuator without the actuator entering into the foaming space. The container includes a female coupling member for mating with a syringe, and a pressure equalizer for equalizing a pressure inside the foaming space with a pressure outside the foaming space. Systems and kits including such containers are also provided. Also disclosed are methods for the preparation of a sclerosant foam which may include a pressure release before extraction of the foam and/or a continued rotation of the actuator while the foam is being extracted.

The present disclosure includes a method for producing a printed circuit board having at least one coating includes mixing a first component with a second component of a two component coating system to form a coating mixture by means of a dynamic mixer or by means of a static-dynamic mixer. The method also includes supplying the coating mixture to an output unit, and coating the printed circuit board by outputting the coating mixture using the output unit onto the printed circuit board. The output unit is moved automatically in at least one, two, or three dimensions relative to the printed circuit board. The mixer is connected with the output unit in such a manner that it is moved together with the output unit relative to the printed circuit board. The present disclosure also includes a coating head for performing the method.

Biosolids conversion systems and methods are provided. Wastewater may be received and separated into a separated water component and a dewatered solids component on-site at or near a wastewater source. The separated water components may be treated on-site using an ancillary water treatment process. The dewatered solids may be converted to a biosolid with aid of one or more oxidizers and a blending chamber. The dewatered solids may be converted to a biosolid on-site at or near a wastewater source or may be converted to a biosolid off-site at a central solids processing facility.

Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

Agitating device (10) for a digester (1) of a biogas plant (100) having a housing (11) and a driving device (12) for rotatably driving the agitator blades (13-15). The driving device (12) comprises a drive shaft (16) and an electric drive motor (20) wherein the drive motor (20) is accommodated sealed in the housing (11). The drive motor (20) comprises an outer, hollow stator (21) and a rotary rotor (22) which is centrally accommodated therein and is configured at least partially hollow. The rotor (22) is rotatably supported at the housing (11) and comprises a coupling device (23) for non-rotatable coupling with the drive shaft (16) to drive the at least one agitator blade (13-15) by means of the drive shaft (16).

A fine bubble generation device in one aspect of the present disclosure is a device that generates fine bubbles in a liquid by causing the liquid to pass through a porous element having many pores. In the fine bubble generation device, a differential pressure is applied between first and second sides of the element, and, by the applied differential pressure, the liquid disposed on the first side of the element is passed through the element and is jetted toward the second side to thereby generate fine bubbles. In this fine bubble generation device, the flow speed of the liquid during passage through the element is 0.009769 [m/s] or higher. The fine bubbles can thereby be generated efficiently.

A manufacturing method for a granulated body includes supplying powder agitated by a dry agitator to a wet agitator, and agitating the powder supplied from the dry agitator with a liquid component in the wet agitator by rotating blades that have inclined surfaces, so as to form a granulated body. The blades are rotated when the powder is supplied to the wet agitator from the dry agitator. The dry agitator agitates the powder in a dry state, and the wet agitator is positioned below the dry agitator. The wet agitator includes an agitation chamber and the blades rotating around a center axis orthogonal to a direction in which the powder is supplied.

A mixer configured for releasing large bubbles into wastewater is provided. The mixer can include a central draft tube, an upwardly-extending member surrounding the draft tube, and an accumulator surrounding both the upwardly-extending member and the draft tube. A lower end of the draft tube sidewall may be sealed and not include any openings beneath the lower end of the upwardly-extending member, so as to prevent liquid pumpage through the draft tube. A method for treating wastewater in a system that includes at least one large bubble mixer and at least one fine bubble diffuser is also provided. The large bubble mixer and fine bubble diffuser may be supplied gas independently from one another. The method can include multiple modes of operation wherein gas is either supplied to the mixer, to the diffuser, to neither the mixer or the diffuser, or to both the mixer or the diffuser.