A cryopreservation system for biological samples is provided. Tire cryopreservation system includes a cooling platform 100 with a 3D printing device that enables a “pick and print” method for processing biological samples 140 for cryopreservation. A syringe or syringes 110 in the 3D printing device picks up biological samples and prints them into a cryogenic environment. A sorting station 200 sorts vitrified samples from unvitrified samples. A warming platform 300 warms the samples using a laser warming system. The cryopreservation system with the sorting station and warming platform are configured for high throughput. Methods for cooling, sorting and warming the biological samples in a high throughput manner are also provided.

A device for collecting and transferring liquid samples having a detachable sample collecting portion includes an elongated body with a liquid collecting portion disposed at one end and a handling portion disposed at the other end separated by a frangible portion. The sample collecting portion includes an inner surface configured to be wetted by the sample. After collection, the sample is transferred into a separate housing by inserting the sample collecting portion filled with sample into a confining cavity and subsequently breaking the sample transfer device along the frangible portion. The liquid sample is extracted from the collecting portion using known means to drive and control flow in fluidic devices including rotation, capillary pressure or pneumatics. The separate housing may be part of a device capable to process the liquid sample to provide for a system for handling liquid samples.

A method of measuring a minimum pressure for gas bubble generation (MPGBG) value of a capillary tube is disclosed. The capillary tube has an inlet and an output portion including an outlet. The inlet is connected to a regulated pneumatic system, configured to supply a gas to the inlet under pressure. The output portion is immersed in a liquid. The gas is supplied to the inlet under a range of pressures including a higher pressure range and a lower pressure range. In the higher pressure range, gas bubbles are generated in the liquid from the outlet. In the lower pressure range, no gas bubbles are generated in the liquid from the outlet. A value of the minimum pressure for gas bubble generation (MPGBG) for the liquid is determined.

Other methods include a method of measuring and storing MPGBG values of capillary tubes, methods of selecting at least one capillary tube from a plurality of capillary tubes, and a method of cutting a capillary tube to a desired MPGBG value.

A blood sample collection and/or storage device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect the sample for storage and optionally process the sample within the housing. The housing may also be opened to access the stored sample for further processing.

Described are exemplary embodiments of a syringe for use with a handheld positive displacement pipette, the syringe being releasably retainable by the pipette. Syringe embodiments may be configured to hold different material volumes. At least certain syringe embodiments may include a cooperative adapter that is used to releasably couple the syringe to the pipette.

The present invention relates to a system and a device for use in the diagnosis of an oral disease. Methods, kits and compositions for use in the diagnosis of oral disease are also provided. More particularly, the invention relates to a system comprising a probe which is configured to collect a fluid sample from the oral cavity of a subject, and a detector which is configured to detect in the fluid sample the presence and/or concentration of an analyte which is indicative of the oral disease.

A testing arrangement and testing method using a manipulator assembly configured to manipulate an apertured surface to and from a sample area and a cleaning area and a controller configured to control the manipulator assembly, wherein the controller includes a sample module configured to control the apertured surface through the sample area, which is configured to contain biological sample targets, and wherein the control system enables re-use of the apertured surface with at least two different biological sample targets.

Devices, kits, and methods related to embodiments of an improved liquid test sample injection device for use in diagnostic assays.

Described are exemplary embodiments of a syringe for use with a handheld positive displacement pipette. The syringe includes a piston having a piston tip that is significantly truncated in comparison to the tips of known positive displacement pipette syringes, and also shorter in length than the dispensing tip of the syringe. The design of the piston tip and its interaction with the syringe dispensing tip results in a substantial reduction in the fluid drag associated with dispensing liquid from a typical positive displacement pipette syringe.

Disclosed herein include systems, devices, and methods for generating and directly loading droplets onto a microfluidic device with contactless delivery. Droplets can be generated and loaded onto a sealed microfluidic device through one or more connecting ports. Loaded droplets can be manipulated, such as merged.