In a method for creating hydrophilic surfaces or surface regions on one or more silicon surfaces of a substrate, a vapour phase of hydrogen peroxide is generated in a reactor by heating an aqueous hydrogen peroxide solution. The substrate having the silicon surface or surfaces to be treated is exposed to the vapour phase, whereby a hydrophilisation of the silicon surfaces in achieved.

In a method for producing a compound of at least two polymer substrates, two polymer substrates each having a connecting surface are provided. At least one of the polymer substrates is coated with a self-assembling polypeptide, at least in the area of the connecting surface. The two polymer substrates are connected by pressing together the connecting surfaces under pressure and at a temperature corresponding to at least the glass transition temperature of the material of one of the polymer substrates at the connecting surface, wherein a diffusion of polymer chains takes place between the connecting surfaces by the self-assembling polypeptide and a solid connection is formed between the two connecting surfaces. A sealed microfluidic cartridge includes a polymer cartridge and a sealing film connected by such a method.

Provided is a preparation method for an immunoelectrode. The immunoelectrode comprises a substrate, a gold layer, a conductive polymer layer and an antibody layer. The substrate, the gold layer, the conductive polymer layer and the antibody layer are sequentially attached from bottom to top. The preparation method for the immunoelectrode specifically comprises the following steps: (1) preparing the conductive polymer layer: preparing a polypyrrole layer on a gold-plated substrate to obtain a polypyrrole/gold-plated substrate; (2) preparing the immunoelectrode: preparing the antibody layer on the polypyrrole layer to obtain an antibody/polypyrrole/gold-plated substrate; and (3) forming an immunoelectrode system: fixing a bare gold-plated substrate to the outer side of the antibody/polypyrrole/gold-plated substrate to obtain the immunoelectrode system. A polypyrrole material is used for fixing an antibody of a biological recognition element and immobilizing the antibody on the immunoelectrode.

An analysis cartridge includes a first cover, a second cover, a plurality of containers, a plurality of fluid tunnels and a rotary valve. The second cover has two opposite surfaces, a plurality of first through holes and a second through hole individually penetrate through the two opposite surfaces, and the first cover is attached to the second cover. The plurality of containers are disposed between the first cover and the second cover, with each of the containers being aligned to and filled in the first through holes. The plurality of the fluid tunnels are disposed on the first cover, and each of which is individually connected with a first pipette. The rotary valve is rotatably disposed between the first cover and the second cover to correspond to the second through hole, and a flow channel disposed on the rotary valve is connected with the containers individually.

A functional material for testing a liquid sample includes a based material in a sheet shape and a channel part provided on a mounting surface of the base material wherein the channel part is composed with water-permeable fibers having permeability, and water-impermeable fibers having impermeability. The water-permeable fibers and the water-impermeable fibers are arranged along the longitudinal direction of the channel part, forming voids wherein the voids are in a mesh structure in which one of the voids connects to another of the voids such that the empty spaces are linked from a base end to a tip end of the channel part. A thickness of the channel part is ranged from 20 μm mm to 5 mm, and a width of the voids is ranged from 10 μm to 200 μm, allowing the liquid sample to move from the base end to the tip end due to capillarity.

A microfluidic sensor for the detection of analytes in objects includes a contact surface that may be attached to a surface of the object, an inlet hole in the contact surface for the entry of fluids emitted by the object, and a first reservoir which stores an ionic fluid in the form of a polymer matrix. The polymer matrix includes a reactive substance which changes colour when it enters into contact with the analytes of the fluids emitted by the object. It further includes at least one first microfluidic duct which connects the inlet hole to the first reservoir. A system for the detection of analytes, a method for the manufacture of the microfluidic sensor and the use of the microfluidic sensor for the detection of analytes in works of art are also related.

An electronically-controlled digital ferrofluidic device is disclosed which employs a network of individually addressable coils in conjunction with one or more movable permanent magnets, where each moveable permanent magnet delivers the designated fluid manipulation-based tasks. The underlying mechanism facilitating fluidic operations is realized by addressable electromagnetic actuation of miniaturized mobile magnets that exert localized magnetic body forces on droplets filled with magnetic nanoparticles. The reconfigurable, contactless, and non-interfering magnetic-field operation properties of the underlying actuation mechanism allow for the integration of passive and active components to implement advanced and diverse operations with high efficiency (e.g., droplet sorting, dispensing, generation, merging, mixing, filtering, and analysis).

Systems and methods for flow cells are provided. Flow cells may encompass a range of fluidic devices for various applications ranging from microfluidic systems to bulk phase flow systems. Flow cells may comprise one or more components for passive or active fluid transfer. Descriptions are provided for advantageous methods of fabricating flow cells for particular applications such as biological assays. Provided is a composition, comprising a first substrate comprising a first covalently-bound ligand; and a second substrate comprising a second covalently-bound ligand; wherein the first covalently-bound ligand and the second covalently-bound ligand are covalently bonded to form a heterocyclic compound. Also provided is a flow cell device, comprising: a first substrate comprising a microfabricated surface; and a second substrate comprising a non-patterned surface; wherein the first substrate is joined to the second substrate to form an enclosure; and wherein the microfabricated surface comprises at least one chamber, wherein the chamber comprises a microarray of active sites with specific functionalization separated by an optically resolvable distance and a functionalized surface comprising a passivating group or a blocking group; and wherein each active site of the microarray of active sites comprises a capture agent.

The present invention provides a magnetic sorting microfluidic chip, including a substrate, a chip model material layer, a micro-channel unit and a magnetic sorting unit, where the chip model material layer is disposed on the substrate, and the micro-channel unit and the magnetic sorting unit are both disposed in the chip model material layer; the micro-channel unit includes a sorting channel and magnetic pole channels; the sorting channel is provided with a plurality of sorting channel inlets and a plurality of sorting channel outlets; and the magnetic sorting unit includes permanent magnets, high-permeability alloys, and magnetic pole arrays disposed in the magnetic pole channels, where the high-permeability alloys are configured to conduct magnetic fields of the permanent magnets to the magnetic pole arrays, so that the magnetic pole arrays generate magnetic fields having opposite polarities on left and right positions of the sorting channel.

A flow stabilized chip includes a chip mainbody, a buffering chamber and two fluid delivery ports. The chip mainbody has a pipe-connection surface. The buffering chamber is disposed in the chip mainbody. The two fluid delivery ports are disposed on the pipe connection surface and connected to the buffering chamber. The chip mainbody includes, in order from the pipe-connection surface to a bottom of the chip mainbody, a first base plate, a first elastic membrane, a second base plate, a second elastic membrane and a third base plate. The first base plate includes a first opening. The second base plate includes a second opening. The third base plate includes a third opening. The first elastic membrane, the second base plate and the second elastic membrane are stacked in sequence to form the buffering chamber.