The present invention relates to novel crystalline forms of ACP-196 (acalabrutinib) salts, compared with the known solid form of ACP-196, the crystalline forms of ACP-196 salts of the present invention have advantages in crystallinity, solubility and hygroscopicity. The present invention also relates to the preparation methods for the preparation of the crystalline forms of ACP-196 salts, pharmaceutical compositions thereof and their uses in the preparation of methods for treating and/or preventing diseases mediated by Bruton tyrosine kinase (BTK), such as autoimmune diseases or disorders, xenoimmune diseases or disorders, cancer, including lymphoma and inflammatory diseases or disorders.

The present invention relates to novel crystalline forms of ACP-196 (acalabrutinib) salts, compared with the known solid form of ACP-196, the crystalline forms of ACP-196 salts of the present invention have advantages in crystallinity, solubility and hygroscopicity. The present invention also relates to the preparation methods for the preparation of the crystalline forms of ACP-196 salts, pharmaceutical compositions thereof and their uses in the preparation of methods for treating and/or preventing diseases mediated by Bruton tyrosine kinase (BTK), such as autoimmune diseases or disorders, xenoimmune diseases or disorders, cancer, including lymphoma and inflammatory diseases or disorders.

A method for reducing the mutagenicity of polycyclic aromatic compounds (PAC's) having one or more bay regions which involves alkylating the PAC's with an alkylating agent in the presence of a catalyst to lower the mutagenicity down to as much as about 0.1. The resulting alkylated polycyclic aromatic compounds retain their physical and chemical properties for safe industrial use including as rubber processing oils, inks, etc.

A process for the addition, incorporation, distribution and/or fixation of a portion of sulphuric acid to/in a material of interest which is intended to include or be provided with the improved properties, any starting materials, phases, layers, internal regions or surface thereof, in the natural state, before, during or after formation/production thereof (where applicable) or when already there (new, used or existing), preferably using a carrier, preferably water. Material resistance is achieved for matter, objects, fluids, products, substances and materials, and controlled synthesis of structures, incarbonization, heat impressions (following exposure to temperature and pressure variations, a situation that results in an increase in material hardness with carbon retention and heat impression in the area affected by heat) are enabled, resulting in products and use thereof.

A process for the addition, incorporation, distribution and/or fixation of a portion of sulphuric acid to/in a material of interest which is intended to include or be provided with the improved properties, any starting materials, phases, layers, internal regions or surface thereof, in the natural state, before, during or after formation/production thereof (where applicable) or when already there (new, used or existing), preferably using a carrier, preferably water. Material resistance is achieved for matter, objects, fluids, products, substances and materials, and controlled synthesis of structures, incarbonization, heat impressions (following exposure to temperature and pressure variations, a situation that results in an increase in material hardness with carbon retention and heat impression in the area affected by heat) are enabled, resulting in products and use thereof.

A process plant including a Claus reaction furnace, a means of Claus gas cooling, a Claus conversion section, a means for Claus tail gas oxidation and a sulfuric acid section, wherein a sulfuric acid outlet of the sulfuric acid section is in fluid communication with an inlet of said Claus reaction furnace, as well as a related process. The process has the associated benefit of such a process avoiding undesired production of sulfuric acid, as well as reducing the Claus process gas volume.

A method for reducing the mutagenicity of polycyclic aromatic compounds (PAC's) having one or more bay regions which involves alkylating the PAC's with an alkylating agent in the presence of a catalyst to lower the mutagenicity down to as much as about 0.1. The resulting alkylated polycyclic aromatic compounds retain their physical and chemical properties for safe industrial use including as rubber processing oils, inks, etc.

This disclosure relates to methods of converting an HF alkylation unit which utilizes HF as a reaction catalyst to a sulfuric acid alkylation unit which utilizes sulfuric acid as a reaction catalyst. This disclosure also relates to a segmented sulfuric acid settler for separating a sulfuric acid phase from a hydrocarbon phase. This disclosure also relates to methods of converting a vertical HF acid settler to a segmented sulfuric acid settler. This disclosure also relates to converted sulfuric acid alkylation units and alkylation processes performed in the converted sulfuric acid alkylation units.

A system for containing an emission of sulfur trioxide, the system comprising a first pressurized vessel, the first pressurized vessel containing sulfur trioxide, a relief vessel containing a volume of a solvent solution, wherein the solvent solution comprises sulfolane, and a first relief conduit providing a first route of fluid communication between the first pressurized vessel and the relief vessel. A method for containing an emission of sulfur trioxide, the method comprising routing a first relief conduit so as to provide a first route of fluid communication between a first pressurized vessel and a relief vessel, wherein the first pressurized vessel contains sulfur trioxide, wherein the relief vessel contains a volume of a solvent solution, and wherein the solvent solution comprises sulfolane.

A system for containing an emission of sulfur trioxide, the system comprising a first pressurized vessel, the first pressurized vessel containing sulfur trioxide, a relief vessel containing a volume of a solvent solution, wherein the solvent solution comprises sulfolane, and a first relief conduit providing a first route of fluid communication between the first pressurized vessel and the relief vessel. A method for containing an emission of sulfur trioxide, the method comprising routing a first relief conduit so as to provide a first route of fluid communication between a first pressurized vessel and a relief vessel, wherein the first pressurized vessel contains sulfur trioxide, wherein the relief vessel contains a volume of a solvent solution, and wherein the solvent solution comprises sulfolane.