A method for preparing keratin-based composites includes mixing polysaccharide nanoparticles and a keratin solution to form a nanoparticle-keratin solution; and solvent casting the nanoparticle-keratin solution to form the keratin-based composites.

The present disclosure provides wound dressing compositions that stimulate nitric oxide production in a wound upon application. The wound dressing composition includes a first layer comprising collagen and an oxidized cellulose and a second layer comprising a nitrite source. Also disclosed herein are kits comprising the wound dressing compositions of the present technology.

The present disclosure provides wound dressing compositions that stimulate nitric oxide production in a wound upon application. The wound dressing composition includes a first layer comprising collagen and an oxidized cellulose and a second layer comprising a nitrite source. Also disclosed herein are kits comprising the wound dressing compositions of the present technology.

A neutral salt consisting of a polyaminosaccharide cation and an anion, as well as a procedure for the preparation of the neutral salt and uses thereof as a biomaterial and as an ingredient in pharmaceutical compositions are disclosed. Indeed, said neutral salt has surprisingly exhibited high water-solubility and high purity, the preparation procedure having minimised the content of high-risk contaminants in the final product and reduced reaction and purification times.

A neutral salt consisting of a polyaminosaccharide cation and an anion, as well as a procedure for the preparation of the neutral salt and uses thereof as a biomaterial and as an ingredient in pharmaceutical compositions are disclosed. Indeed, said neutral salt has surprisingly exhibited high water-solubility and high purity, the preparation procedure having minimised the content of high-risk contaminants in the final product and reduced reaction and purification times.

The invention herein provides biofabricated leather materials, solutions comprising collagen that can be used to create biofabricated leather materials, articles comprising biofabricated leather materials, methods for making biofabricated materials, methods for applying biofabricated proteins to substrates and methods for making three dimensional biofabricated materials.

One aspect of the invention provides a method of sequentially inducing macrophage conversion in a wound. The method includes: (a) administering IL-4 to induce conversion of a first population of wound macrophages in the wound to M2A macrophages; and then (b) administering IL-10, dexamethasone, or a dexamethasone analog to induce conversion of a second population of wound macrophages in the wound to M2C macrophages.

One aspect of the invention provides a method of sequentially inducing macrophage conversion in a wound. The method includes: (a) administering IL-4 to induce conversion of a first population of wound macrophages in the wound to M2A macrophages; and then (b) administering IL-10, dexamethasone, or a dexamethasone analog to induce conversion of a second population of wound macrophages in the wound to M2C macrophages.

Disclosed is a process for solubilising cellulose and coagulating the resulting solution to form a cellulose-containing material. The process comprises contacting a cellulose source with a solvent comprising zinc ions and formic acid to provide a solution, coagulating the solution to provide a solid material, treating the solid material, and isolating the solid material after treatment, to provide the cellulose-containing material. The process can further comprise solubilising protein and coagulating the resulting solution to form a cellulose/protein-containing material. The cellulose-containing materials and cellulose/protein-containing materials can be produced, for example, as reconstituted fibres and films.

Disclosed is a process for solubilising cellulose and coagulating the resulting solution to form a cellulose-containing material. The process comprises contacting a cellulose source with a solvent comprising zinc ions and formic acid to provide a solution, coagulating the solution to provide a solid material, treating the solid material, and isolating the solid material after treatment, to provide the cellulose-containing material. The process can further comprise solubilising protein and coagulating the resulting solution to form a cellulose/protein-containing material. The cellulose-containing materials and cellulose/protein-containing materials can be produced, for example, as reconstituted fibres and films.