A method for optimizing a process (PROC) to produce a biochemical product (P) defined by a quality attribute, the process being controlled by an actuation parameter (C) and being monitored to get a measured value (T). The method includes training a predictive model (PRED) on a training database; and deploying the trained predictive model (PRED) to provide a correction actuation parameter (dC) when a predicted quality attribute (pQA) is out of a targeted quality attribute interval (QAmin, QAmax). The method also includes a step of designing a physical model of the process (PROC) able to provide a simulated quality attribute, the training database comprising simulated quality attributes computed from the physical model and experimental quality attributes computed from biochemical products (P) previously produced.

The invention relates to a fermenter vessel (1) of a biogas plant, having at least one height-adjustable agitator (8), wherein the agitator (8), in the fermenter vessel (1), is guided with a guide element (17) on a guide rail (9) oriented approximately vertically in a vertical axis direction and is held in height-adjustable fashion by means of a traction cable (10). According to the invention, a traction force measuring device (22; 25) is provided for directly and/or indirectly measuring the traction force on the traction cable (10) in accordance with a cable tension, such that, by means of the traction force measuring device (22; 25), in the case of a preferably controlled height adjustment of the agitator (8), varying traction force measurement signals are generated in accordance with varying traction forces and are supplied to an evaluation device (20).

An inverted conical bioreactor is provided for growing cells or microorganisms. The bioreactor has an internal space and a perforated barrier within the vessel, through which a liquid may flow, where cells or microorganisms cannot pass through the perforated barrier. The perforated barrier divides the internal space of the bioreactor into a first chamber and a second chamber. Cells are grown within the second chamber and can be perfused by re-circulating the liquid, for example a growth medium, through the bioreactor. Various inlet ports and outlet ports allow controlling the parameters of flow of the growth medium.

A photobioreactor (PBR) cell comprising a riser portion in the form of a tube; a downcomer portion in the form of a tube; a means of joining the riser portion and the downcomer portion to allow liquid flow; and an aeration means.

Embodiments relate to systems and methods for liquid submerged fermentation to expand inoculum of fungal species, addressing the technical problem of lengthy production times in fungal culture. The solution involves a method comprising inoculating growth media in a sterilized container, agitating the media under optimized conditions, diluting the fungal species in a secondary container, and inoculating bioreactor bags to increase biomass volume. This process enables even colonization and consolidation of the fungal species, resulting in full spectrum fungal biomass production. Embodiments include efficient production of fungal biomass with reduced lead time and labor costs compared to standard systems. Embodiments are applicable to various fungal genera, utilizing specific growth media compositions and controlled environmental conditions to optimize growth and production.

The present invention relates to a method for optimizing a bioprocess purification system comprising a bioreactor configured to provide a harvest comprising a target composition, and a purification process arranged downstream the bioreactor and being configured for purification of the harvest to produce a target product having a desired characteristics. The method comprising: a) detecting (32) at least one quality attribute indicative of characteristics of the target product in a downstream process, b) identifying (33) correlations between the at least one quality attribute measured in the downstream process and parameters to control a cell culture process in the bioreactor, and c) controlling (34) the cell culture process to meet the desired characteristics based on the identified correlations, whereby the target characteristics is within a p re-determined range.

The present invention relates to a method for optimizing a bioprocess purification system comprising a bioreactor configured to provide a harvest comprising a target composition, and a chromatography arranged downstream the bioreactor and being configured for purification of the harvest to produce a target product having a desired characteristics. The method comprising: a) detecting at least one quality attribute indicative of characteristics of the target product in a downstream process, b) identifying correlations between the at least one quality attribute measured in the downstream process and parameters to control a cell culture process in the bioreactor, and c) controlling the cell culture process to meet the desired characteristics based on the identified correlations, whereby the target characteristics is within a pre-determined range.

A cell detachment apparatus that releases cells adhering to a culture surface of a culture base, from the culture surface, by tapping the culture base, the apparatus includes a tapping member configured to tap the culture base, and a tapping control unit configured to move the tapping member and control a position of the tapping member, wherein the tapping control unit stops the tapping member at a position separated from the culture base.

The present application provides an culture vessel active-oscillation slide mechanism and a shaker incubator, which can improve the overall stiffness and stability of the slide mechanism to avoid the creation of lateral bending moment while ensuring the culture vessel in the shaker incubator to fully extend out, and can also simplify the assembly complexity of a stroke amplification mechanism and reduce the number of parts. The culture vessel active-oscillation slide mechanism comprises a slide power transmission device, a slide stroke amplification mechanism and a slide mounting plate. The slide power transmission device can convert a rotational motion of an output shaft of a slide drive motor into a linear displacement in a direction of width. The slide stroke amplification mechanism amplifies the stroke of the linear displacement of the slide power transmission device in the direction of width. Rigid multi-stage rails are mounted on two sides of the slide mounting plate in a direction of length of the incubator body. In the multi-stage rails are configured to, by means of stages of rails partially sliding out relative to each other, support a culture vessel carrier mounting plate that fully extends out after the stroke is amplified.

A method and a device for adherent culture of microalgae in a thin liquid layer by mobile mechanical stirring, comprising: a subsystem for adherent culture of microalgae in thin liquid layer, for adherent culture of microalgae in a culture solution, comprising a microalgae liquid pool and a culture plate used as a base plate for microalgae seed inoculation, adherent culture, microalgae harvesting, the microalgae liquid pool containing culture solution having a water layer with a depth in a range of 1{tilde over ()}5 cm, forming a thin liquid layer; and a subsystem for mechanical stirring, comprising a mechanical stirring assembly, a moving assembly, a track member, a power drive assembly, a control assembly, the moving assembly moving on the track member to drive the mechanical stirring assembly to stir and suspend the microalgae, the microalgae standing and gradually settling to the bottom after stirring, realizing adherent culture in suspension and settlement cycle.