Method for operating a bioprocess installation for production of a bioproduct, wherein the bioprocess installation comprises a source receptacle for cell cultivation, a harvest receptacle for bioproduction and a clarification setup with a centrifuge wherein the source receptacle is operated in a cyclical production mode comprising the steps of: a) starting the cyclical production mode, b) cultivating the cells thereby obtaining a cell broth comprising cultivated cells, c) discharging a discharge fraction of the cell broth, d) combining a restart fraction of the cell broth with fresh cultivation medium and repeating step b), e) repeating steps c) and d) at least once and/or f) discharging the cell broth obtained from step d), obtaining a discharge fraction, wherein the method further comprises the steps: i) centrifuging the discharge fraction via the centrifuge, ii) operating the harvest receptacle in a production mode, wherein steps i) and ii) are executed at least twice.

A system is provided for computer control of production of a cell therapy product in a fluid container. The system provides a container mount for a reactor or fluid container. Software running in electronic memory operates to provide motion to the fluid container which is required for a chosen processing regimen for the cell therapy product within the container. Sequential inspection for accurate ongoing cell processing is provided by digital image comparison of control process images to current digital images whereby the process automatically continues. Remedial actions can be initiated by the system where current imagery does not match control images.