The present invention includes systems, methods and compositions for the generation of water-soluble cannabinoids in yeast, and other plant cell suspension cultures as well as novel water-soluble cannabinoid compounds. The present invention also includes compositions of matter that may contain one or more water-soluble cannabinoids.

A leather-like hybrid mycelial cellulose sheet and production thereof. Precise selection of mushroom species and reagents allows for production at low pH, thereby resulting in a strong, flexible, and dry leather-like material suitable for application in various industries.

A leather-like hybrid mycelial cellulose sheet and production thereof. Precise selection of mushroom species and reagents allows for production at low pH, thereby resulting in a strong, flexible, and dry leather-like material suitable for application in various industries.

Described herein are recombinant edible filamentous fungal strain comprising a genetic modification of a gene in a mycotoxin biosynthesis pathway and methods to produce such recombinant edible filamentous fungal strains. Such recombinant strains comprise reduced levels of mycotoxins. Also described are food materials comprising the recombinant edible filamentous fungal strains described herein, and methods to prepare them.

Provided are an astragalus membranaceus fermentation product and a method of producing the astragalus membranaceus fermentation product, in which a lactic acid bacteria starter or a yeast starter proliferated and cultured in a medium is inoculated into a mixture, in which astragalus membranaceus, sugar, and water are mixed, to be fermented, and then a pH of a fermentation material obtained by fermenting is measured, and the fermentation material having a pH within a predetermined range is filtered and dried to obtain the astragalus membranaceus fermentation product.

Provided are an astragalus membranaceus fermentation product and a method of producing the astragalus membranaceus fermentation product, in which a lactic acid bacteria starter or a yeast starter proliferated and cultured in a medium is inoculated into a mixture, in which astragalus membranaceus, sugar, and water are mixed, to be fermented, and then a pH of a fermentation material obtained by fermenting is measured, and the fermentation material having a pH within a predetermined range is filtered and dried to obtain the astragalus membranaceus fermentation product.

The invention provides a genetically modified micro-organism for intracellular biosynthesis of a cellular metabolite, comprising a synthetic error correction system having a penalty gene, whose expression leads to arrested growth or cell death (e.g. a toxin gene) in combination with a survival gene, whose expression provides an antidote that restores cell viability and normal growth (e.g. a cognate antitoxin gene). Alternatively, the system has a survival gene, alone, whose expression is essential for growth (i.e. essential gene). The synthetic error correction system further comprises a biosensor, whose function is to induce expression of the survival gene which leads to cell growth, only, when the cell produces a pre-defined level of a given metabolite. The invention further encompasses: a method for producing the genetically modified micro-organism; a method for producing a cellular metabolite with the genetically modified micro-organism; and use of the genetically modified micro-organism for producing a cellular metabolite.

The invention provides a genetically modified micro-organism for intracellular biosynthesis of a cellular metabolite, comprising a synthetic error correction system having a penalty gene, whose expression leads to arrested growth or cell death (e.g. a toxin gene) in combination with a survival gene, whose expression provides an antidote that restores cell viability and normal growth (e.g. a cognate antitoxin gene). Alternatively, the system has a survival gene, alone, whose expression is essential for growth (i.e. essential gene). The synthetic error correction system further comprises a biosensor, whose function is to induce expression of the survival gene which leads to cell growth, only, when the cell produces a pre-defined level of a given metabolite. The invention further encompasses: a method for producing the genetically modified micro-organism; a method for producing a cellular metabolite with the genetically modified micro-organism; and use of the genetically modified micro-organism for producing a cellular metabolite.

The present invention provides a composition having functionality to enhance immunity. Differing from all commercial vitamin healthcare foods would cause some adverse effects due to excessive vitamin intake, the present invention proposes a Solanum nigrum-fermented product to be a novel composition having functionality to enhance immunity. Moreover, animal experimental results have proved that, this novel composition would not cause any adverse effects (such as poor appetite or liver damage) even if an adult excessively administer the novel composition. In addition, comparing with the commercial healthcare foods always being made to tablets, the Solanum nigrum-fermented product (i.e., the novel composition) can be processed to various forms, such as powder, tablet, capsule, and drink.

The present invention provides a composition having functionality to enhance immunity. Differing from all commercial vitamin healthcare foods would cause some adverse effects due to excessive vitamin intake, the present invention proposes a Solanum nigrum-fermented product to be a novel composition having functionality to enhance immunity. Moreover, animal experimental results have proved that, this novel composition would not cause any adverse effects (such as poor appetite or liver damage) even if an adult excessively administer the novel composition. In addition, comparing with the commercial healthcare foods always being made to tablets, the Solanum nigrum-fermented product (i.e., the novel composition) can be processed to various forms, such as powder, tablet, capsule, and drink.