This disclosure concerns a medical device and a method for its production, wherein the device comprises a cannula having an elongated hollow shaft and a sharp tip provided at a distal end of the shaft, wherein the shaft is formed as a bent part from a sheet material and confines an interior passage which has a lateral slit opening, and wherein the shaft has at least one longitudinal pre-bending channel provided in the sheet material, wherein the thickness of the sheet material is reduced along the pre-bending channel and a sidewall of the shaft is folded over the pre-bending channel.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

A biomarker detection apparatus in which a CMOS-based chip is used to generate independent detection signals from a reaction zone that receives a biological sample, where the biological sample is provided to both a test region and positive and negative control regions within the reaction zone. The independent detection signals can be processed together (i.e. as a group of input parameters for an algorithm) to identify the presence of a biomarker (or a plurality of biomarkers) in a biological sample. The use of sample-specific, independently detectable positive and negative controls facilitates improved detection accuracy.

A non-invasive wearable sensor device for detecting biomarkers in secretion according to this invention comprises a colorimetric sensor (1), an electrochemical sensor (2), an electrochemical detector and processor (3) and a housing (4). The housing (4) is formed such that allows the colorimetric sensor (1) and electrochemical sensor (2) to contact with the secretion directly and continuously during wearing of the sensor device. This sensor device provides high performance of secretion absorption and retention, leading to high sensitivity to detection of biomarkers using a trace level of secretion sample. This sensor device is developed for detecting biomarkers based on two techniques: the colorimetric sensor (1) which allows the user to interpret a result by comparing it with a standard col or chart, and the electrochemical sensor (2) which provides a digital readout result. This sensor device can be used or simultaneous detection of several biomarkers in the same secretion sample.

A transistor device (10) is disclosed comprising a source electrode (14) a drain electrode (12) and an enzyme (31) for facilitating generation of a charge carrier from an analyte. The transistor device also comprises a polymer layer (30) for retaining the enzyme (31), the polymer layer (30) being conductive to the charge carrier. The device also comprises an ohmic conductor (32) in contact with said polymer layer (30) for applying a gate voltage to said polymer layer (30). The device also comprises an organic semiconducting layer (18) connecting the source electrode (14) to the drain electrode (12). Also disclosed is a method of making and using the device (10).

Biosensor systems including a measurement device and test sensors including at least three independently addressable electrodes, with at least two of the electrodes being substantially chemically isolated are disclosed. One or more working electrodes may be combined with two or more counter electrodes. The two or more counter electrodes may operate at different potentials to provide for multi-analyte electrochemical analysis. Analysis methods are provided to perform multi-analyte electrochemical analysis and test sensors are provided having resistance to chemical mixing between secondary analysis regions.

Techniques and systems are disclosed for implementing textile-based screen-printed amperometric or potentiometric sensors. The chemical sensor can include carbon based electrodes to detect at least one of NADH, hydrogen peroxide, potassium ferrocyanide, TNT or DNT, in liquid or vapor phase. In one application, underwater presence of chemicals such as heavy metals and explosives is detected using the textile-based sensors.

A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, a single set of calibration constants, under-fill, and changes in the active ionizing agent content of the sensor strip.

A method of using an electrochemical device includes at least first and second electrodes; a chamber for receiving a fluid sample and defining a volume partially bounded by a first portion of the first electrode and a second portion of the second electrode, the first portion having a first characteristic for influencing an electrochemical reaction at the first portion, the second portion having a second characteristic for influencing an electrochemical reaction at the second portion, the first and second characteristics having a predetermined relationship. The method also includes receiving a fluid sample in the chamber; measuring first and second electrical outputs at least one of the first and second electrodes; and determining whether the first and second electrical outputs are related according to the predetermined relationship.

The present disclosure presents glucose sensing methods and systems. One such system comprises an electrospun-nanofibrous-membrane (ENFM)-based amperometric glucose sensor integrated on a silicon chip, in which the glucose sensor has a working electrode, a reference electrode, and a counter electrode, wherein the working electrode comprises an ENFM-based sensing electrode. The system further comprises a potentiostat circuit integrated on the silicon chip such that the potentiostat circuit comprises a voltage control unit to control a voltage difference between the working electrode and the reference electrode and a transimpedance amplifier to measure a current flow between the working electrode and the counter electrode, in which a strength of the current flow corresponds to an amount of glucose present in a sample of blood on the glucose sensor.