The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport and electrical conductance.

The specification provides an assay electrode including a composite containing a matrix and a multiplicity of graphene particles dispersed therein.

Subject matter herein can include identifying a biochemical test strip assembly electrically, such as using the same test circuitry as can be used to perform an electrochemical measurement, without requiring use of optical techniques. The identification can include using information about a measured susceptance of an identification feature included as a portion of the test strip assembly. The identification can be used by test circuitry to select test parameters or calibration values, or to select an appropriate test protocol for the type of test strip coupled to the test circuitry. The identification can be used by the test circuitry to validate or reject a test strip assembly, such as to inhibit use of test strips that fail meet one or more specified criteria.

In one embodiment, a working electrode measuring the presence of a first analyte is disclosed. The working electrode includes a working conductor that has a first electrode reactive surface. The working electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry. Additionally, a first reactive chemistry that is responsive to the first analyte is included in the working electrode. The first reactive chemistry includes a mediator, an enzyme and a cofactor. Wherein the first reactive chemistry is located between the working conductor and the first transport material.

A detection device for detecting a marker in a liquid, preferably a fuel, comprising:

a reaction chamber 5, provided with a de-dopable conductive polymer 6 building a path between two conductive pads 10 connected to a resistivity measurement device, wherein the de-dopable conductive polymer 6 is able to be de-doped by a chemical reaction with the marker, changing its resistivity.

Electrochemical biosensor devices and methods of using such devices are provided for detecting low concentration of an analyte in a biological fluid sample. One exemplary embodiment of an electrochemical biosensor device includes a plurality of electrodes made of a buffer layer laid on a substrate layer, an electrode layer laid on the buffer layer, and a perforated insulator layer laid on the electrode layer, such that a plurality of nanowells are formed on the electrode layer and the dimensions of the nanowells are defined by the sizes of the perforations, walls of the nanowells are defined by the insulator layer, and the bottom floors of the nanowells are defined by an upper surface of the electrode layer. In some instances, the nanowells of the biosensors have a pitch ratio of 1:1. In other instances, the biosensors can detect analytes that are present in fM concentration range.

The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The method of measuring a component in blood using a biosensor comprising a first electrode system including a first working electrode on which at least an oxidoreductase that acts upon the component and a mediator are provided and a first counter electrode and a second working electrode on which the mediator is not provided. The first working electrode and the first counter electrode are used for obtaining the amount of the component and the second working electrode and the first working electrode are used for obtaining the amount of the blood cells.

Nanozymes capped with a radical-scavenging capping agent are disclosed for use in biosensing assays with improved sensitivity. The radical-scavenging capping agent facilitates the capture and retention of one or more radicals for enhancing a catalytic reaction. In some example embodiments, the nanozyme capped by the radical-scavenging capping agent is capable of catalyzing the decomposition of hydrogen peroxide or molecular oxygen. The capped nanozymes may be incorporated with an electrode, such as the working electrode of an electrochemical sensor, for achieving enhanced catalytic activity and a lower limit of detection. In some example embodiments, the radical-scavenging capping agent is or includes thiocyanate. A rapid ethanol detection device and associated method are described in which the working electrode of an electrochemical sensor is modified by a peroxidase-mimetic nanozyme capped with a radical-scavenging capping agent for the enhanced generation of a reduction current associated with the decomposition of hydrogen peroxide.

A test strip, a detecting device, and a detecting method are disclosed. The test strip includes a first specimen path, a first electrode set, a second specimen path, a second electrode set, and a reaction reagent. When the specimen contacts the first electrode set and the second electrode set, a first pulse signal and a second pulse signal are generated for obtaining a flow time of the specimen. When the specimen contacts the reaction reagent, the analyte concentration of the specimen can be obtained, and the concentration of the analyte can be corrected by the flow time.

Described herein are three-dimensional (3-D) paper fluidic devices. The entire 3-D device is fabricated on a support layer formed from a single sheet of material and assembled by folding the support layer. The folded structure may be enclosed in an impermeable cover or package. Chemically sensitive particles may be disposed in the support layer for use in detecting analytes.