Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.

Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.

The present invention relates to a method for controlling a phythopatogenic fungi selected from Uncinula necator, Plasmopara viticola and Gloeosporium ampelophagum in grapes, comprising treating the plants, their seed or the soil with a fungicidally effective amount of a composition comprising mefentrifluconazole (I) and a further active compound (II) selected from bixafen, boscalid, dimoxystrobin, fenpropimorph, fluopyram, fluxapyroxad, kresoxym-methyl, metyltetraprole, oxathiapiprolin, quinofumelin, picarbutrazox, pydiflumetofen, pyraclostrobin, 1-(4,5-dimethylbenzimidazol-1-yl)-4,4,6-trifluoro-3,3-dimethyl-isoquinoline, 6-chloro-1-(4,5-dimethylbenzimidazol-1-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline, 1-(4,5-dimethylbenzimidazol-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline, 4,4-difluoro-3,3-dimethyl-1-(4-methylbenzimidazol-1-yl)isoquinoline, 1-(6-chloro-7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-1 isoquinoline, 4,4-difluoro-1-(6-fluoro-7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-3,3-dimethyl-isoquinoline, 4,4-difluoro-3,3-dimethyl-1-(6-methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline, 1-(6,7-dimethylpyrazolo [1,5-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline, 1-(7,8-dimethylimidazo[1,2-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline, 4-[1-[2-[3-(difluoromethyl)-5-methyl-pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[3-(difluoromethyl)-5-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[5-cyclopropyl-3-(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[5-(difluoromethyl)-3-2 (trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[3,5-bis(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide and 4-[1-[2-[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide.

The present invention relates to a method for controlling a phythopatogenic fungi selected from Uncinula necator, Plasmopara viticola and Gloeosporium ampelophagum in grapes, comprising treating the plants, their seed or the soil with a fungicidally effective amount of a composition comprising mefentrifluconazole (I) and a further active compound (II) selected from bixafen, boscalid, dimoxystrobin, fenpropimorph, fluopyram, fluxapyroxad, kresoxym-methyl, metyltetraprole, oxathiapiprolin, quinofumelin, picarbutrazox, pydiflumetofen, pyraclostrobin, 1-(4,5-dimethylbenzimidazol-1-yl)-4,4,6-trifluoro-3,3-dimethyl-isoquinoline, 6-chloro-1-(4,5-dimethylbenzimidazol-1-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline, 1-(4,5-dimethylbenzimidazol-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline, 4,4-difluoro-3,3-dimethyl-1-(4-methylbenzimidazol-1-yl)isoquinoline, 1-(6-chloro-7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-1 isoquinoline, 4,4-difluoro-1-(6-fluoro-7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-3,3-dimethyl-isoquinoline, 4,4-difluoro-3,3-dimethyl-1-(6-methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline, 1-(6,7-dimethylpyrazolo [1,5-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline, 1-(7,8-dimethylimidazo[1,2-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline, 4-[1-[2-[3-(difluoromethyl)-5-methyl-pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[3-(difluoromethyl)-5-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[5-cyclopropyl-3-(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[5-(difluoromethyl)-3-2 (trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide, 4-[1-[2-[3,5-bis(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide and 4-[1-[2-[5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]-N-tetralin-1-yl-pyridine-2-carboxamide.

The present invention relates to tetrazolylpropyl derivatives of formula (I) ##STR00001##
wherein one of V.sup.1 and V.sup.2 represents CR.sup.3 and the other one of V.sup.1 and V.sup.2 represents N, Q represents a 6-membered aromatic cycle as defined in the specification, and R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined as disclosed in the specification, to compositions comprising such compounds, to the use of said compounds as fungicides, as well as to particular intermediates useful in the synthesis of said tetrazolylpropyl derivatives.

The present invention relates to tetrazolylpropyl derivatives of formula (I) ##STR00001##
wherein one of V.sup.1 and V.sup.2 represents CR.sup.3 and the other one of V.sup.1 and V.sup.2 represents N, Q represents a 6-membered aromatic cycle as defined in the specification, and R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined as disclosed in the specification, to compositions comprising such compounds, to the use of said compounds as fungicides, as well as to particular intermediates useful in the synthesis of said tetrazolylpropyl derivatives.

Disclosed herein are biocontrol compositions against plant fungal pathogens and methods of use thereof for the prevention or reduction of crop loss or food spoilage. The biocontrol composition can comprise at least one microbe with anti-fungal activity or a secondary metabolite of the at least one microbe. The methods can comprise application of the biocontrol composition to a plant, a seed, or a produce thereof or to a packaging material used to transport or store the produce.

An insecticidal composition for pest control comprising diacylhyrazines. More particularly the present invention related to a synergistic agrochemical insecticidal composition comprising of bioactive amount of at least one insecticide from diacylhydrazines group; at least one insecticide from diamide or a pyridylpyrazole group; and at least one insecticidal compound selected from Acephate, Profenofos, Fipronil, Bifenthrin, lambda-cyhalothrin, Clothiandin, Dinotefuran, Thiamethoxam, Pymetrozine, Spinetoram, Spinosad, Emamectin benzoate, Novaluron, Indoxacarb, Azadirechtin. The present invention further relates to process for preparing the said compositions in specific ratio. The present invention further relates to the process for preparing the said composition along with at least one inactive excipient; and formulations thereof. The present invention further relates to the synergistic insecticidal compositions, wherein active ingredient present in fixed ratio shows synergy in an insecticidal activity.

An insecticidal composition for pest control comprising diacylhyrazines. More particularly the present invention related to a synergistic agrochemical insecticidal composition comprising of bioactive amount of at least one insecticide from diacylhydrazines group; at least one insecticide from diamide or a pyridylpyrazole group; and at least one insecticidal compound selected from Acephate, Profenofos, Fipronil, Bifenthrin, lambda-cyhalothrin, Clothiandin, Dinotefuran, Thiamethoxam, Pymetrozine, Spinetoram, Spinosad, Emamectin benzoate, Novaluron, Indoxacarb, Azadirechtin. The present invention further relates to process for preparing the said compositions in specific ratio. The present invention further relates to the process for preparing the said composition along with at least one inactive excipient; and formulations thereof. The present invention further relates to the synergistic insecticidal compositions, wherein active ingredient present in fixed ratio shows synergy in an insecticidal activity.

An insecticidal composition for pest control comprising diacylhyrazines. More particularly the present invention related to a synergistic agrochemical insecticidal composition comprising of bioactive amount of at least one insecticide from diacylhydrazines group; at least one insecticide from diamide or a pyridylpyrazole group; and at least one insecticidal compound selected from Acephate, Profenofos, Fipronil, Bifenthrin, lambda-cyhalothrin, Clothiandin, Dinotefuran, Thiamethoxam, Pymetrozine, Spinetoram, Spinosad, Emamectin benzoate, Novaluron, Indoxacarb, Azadirechtin. The present invention further relates to process for preparing the said compositions in specific ratio. The present invention further relates to the process for preparing the said composition along with at least one inactive excipient; and formulations thereof. The present invention further relates to the synergistic insecticidal compositions, wherein active ingredient present in fixed ratio shows synergy in an insecticidal activity.