A medical needle arrangement (100, 1000, 1400) is disclosed. The needle arrangement (100, 1000, 1400) comprises: a needle sheath (104, 002, 1402), and a needle (202, 1102, 1406) comprising: an elongated portion and a sealing member (204, 1003, 1403) being arranged to a front end of the elongated portion. The needle arrangement is adapted to bet set in: a closed position, in which the sealing member (204, 1003, 1403) is arranged to abut at least a portion of a front end surface of the needle sheath (104, 1002, 1402) thereby restricting intrusion of foreign matter in an area between the needle sheath and the needle, and an open position, in which a gap (1204, 1506) is formed between the sealing member (204, 1003, 1403) and the front end surface of the needle sheath (104, 1002, 1402). Embodiments include needle arrangement for injection, for aspiration, and for biopsy purposes.

A universal single-handed device for self-collection of a biological sample is described herein. The single-handed device may comprise a sheath comprising a distal end for insertion into a portion of a user's body, a shaft at least partially within the sheath, having a collection head for collecting the biological sample positioned at the distal end thereof, and an actuator coupled to the shaft to transition the distal end between an open configuration and a closed configuration. The collection head is covered by the distal end in the closed configuration and is exposed when the distal end is in the open configuration.

A device for collecting uterine fluid is described which can be used in vivo in both animals and humans, without said use causing dilution of fluid components or damage to the endometrium.

Provided herein is a pre-Caesarean method for collecting amniotic fluid from a patient. A needle is inserted into the incision site for the future C-section, which may be under ultrasound guidance, through which the amniotic fluid is drawn under a low level suction and, optionally, gravity to a sterile collection container. The method encompasses filtering and/or irradiating the amniotic fluid to collect biomolecules of interest such as growth factors and/or stem cells. Also provided is the sterile amniotic fluid or filtrates thereof collected by the method described herein.

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir.

A device for making an amniotic cavity access through a mother and method thereof is disclosed, which includes a transvaginal fetal membrane puncture assembly configured to construct the amniotic cavity access through a natural orifice of a maternal vagina, a trans maternal abdominal wall uterine fetal member puncture assembly configured to construct the amniotic cavity access through the maternal abdominal wall and/or a belly button, and an amniotic cavity combined sheath configured to form the amniotic cavity access for placing a fetus positioning surgical robotic arm and/or surgical instruments, thereby providing a safe operation channel for the implementation of an intrauterine fetal minimally invasive surgery.

A fluid withdrawing, expelling and filtering apparatus includes a fluid container including a first chamber, a second chamber, and, a first through hole and a second through hole respectively disposed in communication between the first chamber and the second chamber, a filter device movable between a first position and a second position to open or close the second through hole of the fluid container and including a filter element mating with the first through hole, and a fluid withdrawing and expelling operator operable to withdraw and expel a fluid through the first chamber of the fluid container.

In one embodiment of the disclosure, a method of monitoring a fetus in utero is disclosed that includes implanting a medical device into a patient's uterus, collecting fetal data using the medical device, and transmitting, e.g., wirelessly, the fetal data from the medical device to a receiver. In another embodiment, a medical monitoring system is disclosed that includes a first device that is implantable into a patient's uterus for collecting fetal data, and a second device that is configured and dimensioned for connection with the first device such that the fetal data is wirelessly communicable from the first device to the second device.

In certain embodiments, a method for communicating with a fetus may include providing, on an electronic device, a user interface configured to facilitate wireless communication of signals between the electronic device and at least one implanted device located in proximity to the fetus; and responsive to a user selecting a communication selection element, causing the wireless communication of signals inclusive of content data between the electronic device and implanted device.

An apparatus includes a housing, a flow control mechanism, and an actuator. At least a portion of the flow control mechanism is movably disposed within the housing. The apparatus further includes an inlet port and an outlet port, and defines a fluid reservoir. The outlet port is fluidically coupled to a second fluid reservoir and is fluidically isolated from the first fluid reservoir. The actuator is configured to move the flow control mechanism between a first configuration, in which the inlet port is placed in fluid communication with the fluid reservoir such that the fluid reservoir receives a first flow of bodily-fluid, and a second configuration, in which the inlet port is placed in fluid communication with the outlet port.