One aspect relates to a bone cement applicator having a cartridge with an interior, a cartridge head with a delivery opening, a mixing member which is movable in the interior with a mixing rod. A delivery plunger is arranged in the cartridge and is mounted in the interior and is pressable in the direction of the delivery opening. The delivery plunger rests with an outer cylindrical circumferential surface against an inner wall of the cartridge. A clamping element is arranged on the inner wall of the cartridge in the region of a back side of the interior. The clamping element projects out of the inner wall of the cartridge. The cylindrical circumferential surface of the delivery plunger is resiliently deformable by the clamping element in the direction of a central cylinder axis, such that the delivery plunger is clampable in place with the at least one clamping element on the back side of the cartridge.

A dispensing system includes a main body having a base and an extension extending from the base. The extension includes an inner surface defining a passageway. The main body includes an opening that extends through the extension. The opening is in communication with the passageway. A first plunger is configured to be positioned within the passageway. The first plunger includes a lumen extending through and between opposite proximal and distal end surfaces of the first plunger. A second plunger is configured to be positioned within the lumen. Kits and methods are disclosed.

Inflatable medical devices and methods for making and using the same are disclosed. The inflatable medical devices can be medical balloons. The balloons can be configured to have a through-lumen or no through-lumen and a wide variety of geometries. The device can have a high-strength, non-compliant, fiber-reinforced, multi-layered wall. The inflatable medical device can be used for angioplasty, kyphoplasty, percutaneous aortic valve replacement, or other procedures described herein.

The present invention provides a negative pressure guided bone cement injection system comprising a negative pressure system, comprising a negative pressure introduction device, a pushing system for implant bone cement to the target area, a control system for regulating the negative pressure system and the pushing system, and at least one sensing device disposed at any position of the negative pressure system, which can sense at least one environmental parameter for observing the physiological condition of a patient's spinal vertebral body can be monitored immediately, and the result is actively or passively sent back to the system or the operator for adjusting the injection parameters.

A syringe system includes a syringe and a pressurization device for a syringe. The pressurization device for a syringe is configured so that the plunger advances by a forward rotation of the plunger, and the plunger retracts by a reverse rotation of the plunger. The plunger is advanceable by pressing the gasket at the time of the forward rotation and is retractable with respect to the barrel without pulling the gasket in the proximal end direction at the time of the reverse rotation.

A device and method for applying a pharmaceutical fluid comprising a hollow cylindrical body, which surrounds a channel that extends through the body from a proximal body end to a distal body end of the body, wherein an outer surface of the body has at least partially an external thread, and has a connecting element arranged at the proximal body end, via which a proximal channel end of the channel can be reversibly connected in terms of fluid conduction to a reservoir for the pharmaceutical fluid.

A system (30) for dispensing curable material. A lead screw (62) is rotatably fixed relative to a first control surface (60) and includes external threads (94). A locking nut (90) includes internal threads (92) threadably engaging the external threads. An engagement feature (98) of the locking nut is adapted to be selectively engaged with an actuator (120) having a second control surface (122). The threads provide for rotation of the locking nut about a translation axis when the actuator is in a disengaged position. Rotation of the locking nut permits the lead screw to move proximally along the axis and the compressed curable material to at least partially decompress within a dispensing volume. The threads further provide for distal advancement of the lead screw along the axis when the actuator is in an engaged position rotatably fixing the locking nut about the axis. Methods for operating and packaging the curable material dispensing system are also described.

A dispensing system includes a main body having a base and an extension extending from the base. The extension includes an inner surface defining a passageway. The main body includes an opening that extends through the extension. The opening is in communication with the passageway. A first plunger is configured to be positioned within the passageway. The first plunger includes a lumen extending through and between opposite proximal and distal end surfaces of the first plunger. A second plunger is configured to be positioned within the lumen. Kits and methods are disclosed.

A system for dispensing curable material. A lead screw is rotatably fixed relative to a first control surface and includes external threads. A locking nut includes internal threads threadably engaging the external threads. An engagement feature of the locking nut is adapted to be selectively engaged with an actuator having a second control surface. The threads provide for rotation of the locking nut about a translation axis when the actuator is in a disengaged position. Rotation of the locking nut permits the lead screw to move proximally along the axis and the compressed curable material to at least partially decompress within a dispensing volume. The threads further provide for distal advancement of the lead screw along the axis when the actuator is in an engaged position rotatably fixing the locking nut about the axis. Methods for operating and packaging the curable material dispensing system are also described.

An inflatable bone tamp is provided that includes a shaft defining a lumen. A balloon is coupled to the shaft such that a material can flow through the lumen and into the balloon to inflate the balloon. A connector is coupled to the shaft. The connector includes a first port and a second port. The ports are in communication with the lumen. A flow control device is coupled to the first port. The flow control device controls flow of the material through the first port and into the lumen. A damper is coupled to the second port. The damper controls pressure within the inflatable bone tamp when pressure within the inflatable bone tamp reaches a threshold. Kits, systems and methods are disclosed.