The present invention provides a sampling capsule and a sampling capsule system. The sampling capsule includes an enclosure, a partition wall arranged in the enclosure, and a sample chamber enclosed by the partition wall and the enclosure at a first side of the partition wall. The sampling capsule further includes an inner sample inlet on the partition wall, an outer sample inlet, a sampling tube and a switch assembly. The outer sample inlet is on the enclosure at a second side of the partition wall. The sampling tube connects the outer sample inlet and the inner sample inlet, and the switch assembly clamps or unclamps a portion of the sampling tube. When sampling is needed, the switch assembly unclamps the sampling tube to sample liquid. When sampling ends, the switch assembly tightly clamps the sampling tube to prevent sample liquid leak or contamination.

The present invention provides a gastrointestinal liquid biopsy sampling device. The sampling device includes an enclosure and expandable materials. The enclosure includes through holes cut in the wall of the enclosure, and targeted dissolution membranes covering the through holes that can be dissolved at targeted regions. The expandable materials are arranged at the positions corresponding to the through holes. The expandable materials expand after absorbing liquid and close the through holes.

Provided is a non-invasive and prompt testing method, in which a mucus adhering onto the surface of a mucous membrane is used as a specimen.

A method for collecting a specimen by wiping out a mucus adhering onto the surface of a mucous membrane, when the specimen is collected during an endoscopic examination.

An ingestible electronic capsule for the collection of samples along a gastric intestinal tract and methods relating thereto are provided. The ingestible electronic capsule includes a housing and a cap that form an interior chamber. The cap includes a sampling port and one or more sample collection chambers are disposed within the interior chamber. A motor is also disposed within the interior chamber and is configured to rotate one of the cap and the one or more sample collection chambers so to align one or the one or more sample collection chambers and the sampling port of the cap so to allow for sample collection. A microcontroller is also disposed within the interior chamber and is in communication with at least the motor. The microcontroller is configured to control the selective alignment of the sampling port and one of the one or more sample collection chambers and induce gastric intestinal fluid sampling.

The invention relates to cell sampling devices. In particular, the present invention relates to ingestible cell sampling devices for sampling cells in a subject, and methods of use for detecting abnormalities in a subject using the same.

The present disclosure relates to an ingestible device for sampling of the gastrointestinal tract. In particular, the device comprises an oral delivery capsule comprising a container having on the inside a hydrogel pre-polymer. The hydrogel prepolymer is capable of polymerising in situ, such as within the gastrointestinal tract, thereby collecting a sample of the gastrointestinal lumen by absorbing the lumen and its contents into the formed hydrogel.

The present invention provides a capsule for fluid sampling and drug delivery including: an enclosure; a sampling/drug delivery assembly, including a storage chamber arranged in the enclosure, a first one-way element and a second one-way element communicating with outside of the capsule and the storage chamber, and a pump changing pressure in the storage chamber, wherein the first one-way element and the second one-way element have same direction of access; and a control module, including a microprocessor in communication with the pump. The capsule can realize multiple times of sampling and drug delivery by means of control flow direction of sample or drug through the first one-way element and the second one-way element, and by changing the pressure of the storage chamber through the pump.

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir.

Medical waste collection manifolds that that may connect to a vacuum system to create suction, such that liquid, semi-solid, or solid biological or medical waste may be collected are provided. The manifold may be configured to collect hazardous waste in a manner to ensure proper containment.

Various embodiments are described herein for a device, system, and method for identifying a location of an ingestible device within a gastrointestinal tract of a body. In some embodiments, the ingestible device includes a sensing unit with an axial optical sensing sub-unit located proximal to at least one end of the device, and a radial optical sensing sub-unit located proximal to a radial wall of the device, and may autonomously identify a location within the gastrointestinal tract. In some embodiments, the ingestible device includes optical illumination sources and detectors that operate at a plurality of different wavelengths, and may discern regions of a gastrointestinal tract by using the reflection properties of organ tissue and occasional particulates. In some embodiments, the ingestible device may sample fluid or release medicament based on a detected device location.