A device for closing an aperture in a vessel wall, the aperture having an external opening in an external region of the vessel wall and an internal opening in an internal region of the vessel wall. The device includes a covering member positionable inside the vessel against the internal opening of the aperture and having a dimension to prevent egress of fluid through the aperture. A securing member is positionable external of the vessel and has a plurality of pores extending therethrough. A flexible connecting member operatively connects the covering member and securing member and moves the securing member toward the covering member.

A wound closure device comprises a first frame and a flexible tubular section connected to the first frame, the first frame implantable through a wound in a patient's skin into a lumen of a blood vessel with a portion of the tubular section extending out through the skin. The tubular section has a first portion and a second portion, a wall of the tubular section defining a coaxial inner bore. Twisting the first portion relative to the second portion of the tubular section closes the bore is closed in an area of the tubular section between the first and second portions, thereby closing the wound. Also disclosed is an embodiment for closing an opening in a heart, as well as a delivery device, systems, and methods.

A use of an umbilical splint for shaping an umbilicus after an abdominal operation is described. The umbilical splint may comprise an insertion portion extending in a longitudinal direction and terminating at an insertion end for insertion into the umbilicus. Furthermore, the insertion portion may comprise a bulbous section near the insertion end. The bulbous section may be operable to apply pressure to a tissue of the umbilicus after the abdominal operation. The insertion portion may have different cross-sectional shapes including circular and oval. Finally, the insertion portion may be configured to engage the umbilicus such that the umbilical splint is retained within the umbilicus.

The disclosed technology provides a device for sealing an aperture in a tissue of a body lumen. The device comprises a flexible support member having a base having (i) a central portion and (ii) one or more lateral support portions, to engage and/or hold a sealable member of the device against an interior surface of the tissue when the device is in the sealing position. The lateral support portions provide additional support surfaces to engage peripheral portions of the sealable member against the interior surface of the tissue.

An implantable closure device for sealing an opening through a biologic tissue membrane against leakage of biological fluid includes a fluid sealing plug configured to be positioned within the opening. One or more retainer sections are configured to secure the fluid sealing plug within the opening. The retainer sections include at least one of a distal retainer section coupled to a distal end of the fluid sealing plug and configured to be disposed distally on the biologic tissue membrane, or a proximal retainer section coupled to a proximal end of the fluid sealing plug and configured to be disposed proximally on the biologic tissue membrane.

A fistula treatment system comprises a guide such as a guide coil 1101 which is adapted to extend partially around a tissue tract and an implant element 1102. The implant element 1102 is activated to draw tissue surrounding the tract inwardly.

A self-closing device for implantation within a patient's body includes base material including an inner surface area for securing the base material to a tissue structure, and a plurality of support elements surrounding or embedded in the base material. The support elements are separable to accommodate creating an opening through the base material for receiving one or more instruments through the base material, and biased to return towards a relaxed state for self-closing the opening after removing the one or more instruments. The device may be provided as a patch, cuff, or integrally attached to a tubular graft or in various shapes.

Described are medical graft products, systems, and methods for treating fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening, e.g., one occurring in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member, which is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and an elongate plug member extending from the capping member, which is configured to extend into at least a portion of the fistula. In certain embodiments, a graft body component has the capacity to expand or otherwise change form to provide a suitable capping arrangement. Such a component can include a resilient wire frame, e.g., one that is self-expandable or one that requires at least some manipulation in order to expand.

The present invention relates generally to the field of closing of openings in vessel walls, i.e. closure of vascular holes, in particular access to and closure of an access point through the wall of a human vessel, and more specifically to the hemostatic closure and structural support of an opening such as an access point through a fluid filled vessel, particularly a human vessel, be that an artery, vein or other body conduit.

A method of inducing retrograde blood flow may include extending a sheath through opposite walls of one of an artery and a vein of a subject and through a wall of the other of the artery and the vein such that a distal end of the sheath may be positioned within one of the artery and the vein. The method may include inducing retrograde blood flow in the artery and delivering the induced retrograde blood flow into the vein of the subject via the sheath.