A clot retrieval device for removing an occlusive clot from a blood vessel. The device includes a clot engagement section having a constrained delivery configuration and an expanded deployed configuration, wherein in the expanded deployed configuration. The clot engagement section can include a plurality of peak sections configured to vary contact pressure between the clot and the device along a length of the device; and a plurality of troughs between respective peak sections comprising a clot reception space. Each peak is configured to exert a relatively high compressive force on the clot whereas each trough is configured to exert little or no compressive force on the clot.

Disclosed herein are devices for mechanically removing clot and/or other material from implants implanted in the vasculature of a patient, and associated systems and methods. In some embodiments, a system for removing clot material from an implant—such as a stent—includes a clot treatment device configured to be deployed within the stent, a handle, and a first elongate member and a second elongate member coupling the clot treatment device to the handle. The first elongate member couples a first end portion of the clot treatment device to the handle, and the second elongate member couples a second end portion of the clot treatment device to an actuator of the handle. Actuation of the actuator is configured to move the second elongate member relative to the first elongate member to move the first and second end portions toward one another to radially expand the clot treatment device.

Method of endovascular intervention in neurovascular anatomy of a patient including deploying an anchor of a tethering device in an anchoring vessel of a neurovascular anatomy, the anchor coupled to a tether extending proximally from the anchor. Method includes advancing a guide-sheath over the tether of the tethering device anchored in the anchoring vessel and attached to the tether, the guide-sheath includes at least one lumen and a distal opening from the lumen. Method includes advancing a treatment device through the lumen of the guide-sheath and out the distal opening from the at least one lumen and through an entrance of a target intracranial vessel, and deploying the treatment device at a treatment site within the target intracranial vessel without a combined therapy of two or more anti-platelet therapeutic agents during a peri-procedural period. Related systems, devices, and methods are disclosed.

In some examples, a capture assembly configured to remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system, includes a body configured to receive the material of interest. The body can be configured to axially lengthen and shorten.

An endoscope treatment tool includes: a sheath; an operating wire in the sheath; a gripping portion provided at a distal end of the operating wire and having one or more wires; a tip attached to a distal end of the sheath; and a resin member disposed at a position adjacent to the tip on a radially inner or outer side thereof, wherein the tip includes clearance grooves extending toward a proximal end of the tip from a distal end of the tip, passing therethrough from an inner circumferential surface of the tip to an outer circumferential surface of the tip, and having sizes enabling the wires to pass therethrough, and at least proximal-end sides of the grooves overlap with the member in a radial direction of the tip and a distal end of the member is disposed farther on a distal-end side than proximal ends of the grooves are.

An interventional catheter for treating an artery includes an elongated body sized and shaped to be transcervically introduced into a common carotid artery at an access location in the neck. The elongated body has an overall length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section is positioned in the common carotid artery during use.

An apparatus for neurovascular endoluminal intervention, in particular for the treatment of ischemic stroke, is provided. The apparatus comprises a catheter (2) for insertion into the circulatory system (CS) of a patient, in order to aspirate one or several clots (C) present in the circulatory system (CS). A distal outer section (22) of the catheter (2) comprises an unexpanded state, in which the diameter (D2) of the distal outer section (22) is smaller than the diameter (D1) of a proximal outer section (21) of the catheter (2), in order to facilitate navigation of the catheter through the circulatory system, and a radially expanded state, in order to facilitate aspiration of the one or several clots (C) through the catheter (2). Furthermore, a method for applying such an apparatus is provided.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

An endarterectomy device configured to remove plaque from an occluded artery is disclosed. The endarterectomy device uses an adjustable wire loop end effector to establish and advance a dissection plane in the subadventitial space of the artery. The endarterectomy device is passed down the length of an artery in the subadventitial plane, adjusting the size of the wire loop end effector as needed to navigate the artery and dissect a plaque column, until the end of the plaque is reached. The wire loop end effector is then used as a plaque cutter to transect the distal end of the plaque column. The endarterectomy device is further configured along its length with support arms that facilitate removal of the plaque column as the device is removed from the artery.

A surgical instrument assembly is provided. In some embodiments, an example surgical instrument assembly includes a surgical instrument configured to pass through a guide tube having a proximal end and a distal end. The surgical instrument can include one or more arms configured to extend from the intermediate position, each arm having one or more joints positioned along the arm and an end effector attached at the distal end of each arm. The surgical instrument assembly can include a control assembly positioned at the proximal end and configured to control the movement of the joints and the end effectors.