Systems and methods for treating tissue by concentrating a laser emission to at least one depth at a fluence sufficient to create an ablation volume in at least a portion of the target tissue and controlling pulse width within the picosecond regime to provide a desired mechanical pressure in the form of shock waves and/or pressure waves.

A method for inhibiting device thrombosis for a patient may include circulating blood through an extracorporeal circuit coupled to the patient, infusing nitrite into the flow of blood such that the nitrite is bioactivated by red blood cells to form nitric oxide, and illuminating the flow of blood with far-red light to increase bioactivation of the nitrite by the red blood cells. A system for inhibiting device thrombosis for a patient may include an extracorporeal circuit configured to circulate a flow of blood, a nitrite infusion device coupled to the extracorporeal circuit and configured to infuse nitrite into the flow of blood, and one or more light sources disposed along the extracorporeal circuit and configured to illuminate the flow of blood with far-red light.

The present disclosure provides a method of removing a target substance from blood of a patient, the method comprising steps of: providing a complexing agent, especially a supra-molecular compound or core particle, adapted for selectively binding a target molecule or target entity in the blood of the patient in a complex, e.g. a supra-molecular complex; administering the complexing agent into the patient's blood, preferably into an extracorporeal blood flow pathway, for binding with the target molecule or the target entity; conveying the blood having the complexing agent through a treatment zone of an extracorporeal blood flow pathway for a predetermined period of time to bind or incorporate the target molecule or target entity within the blood in a complex, such as a supra-molecular complex; and removing the complex (e.g. supra-molecular complex) from the blood by haemodialysis, which preferably includes one or more of filtration, ultrafiltration, convection, or adsorption. The disclosure thus also provides a system (1) for removing a target substance from blood of a patient, the system (1) comprising: an extracorporeal blood flow pathway (2) for connection to a patient and for guiding or conveying a flow of blood from the patient along the pathway; a treatment zone (5) arranged in the extracorporeal blood flow pathway (2) for mixing a complexing agent (C) with the blood adapted to bind a target molecule (M) in a complex (X), especially a supra-molecular complex or core particle complex, as the blood flows through the treatment zone (5); and a haemodialysis unit (4) for separating the complex (X) from the blood via one or more of filtration, ultra-filtration, convection, and membrane adsorption, with or without magnetic assistance.

A prosthetic liner for use with a prosthetic socket that has a thermoplastic elastomeric (TPE) layer that is in contact with the amputee's residual limb. The TPE layer is not uniform in thickness but has ridges to extend circumferentially around the TPE layer. A fabric exterior layer covers the outer surface of the TPE layer conforming to the ridges and is used as a substrate to form a mechanical bond to an elastomeric material. Impregnating the elastomeric material within the fabric exterior occurs by applying an uncured material to the fabric exterior layer and onto at least the apex surfaces located within the sealing regions thereby creating an air tight boundary layer when inserted into a socket. When a vacuum is applied the air is evacuated from the volume below the seal layer.

A surgical instrument includes a housing having a shaft extending distally therefrom, an end effector assembly disposed at a distal end of the shaft, a handle assembly coupled to the housing for manipulating the end effector assembly, a deployable assembly, at least one actuator for deploying and retracting the deployable assembly, and a closure member. The closure member is keyed to the actuator(s) and operably positioned relative to the movable handle of the handle assembly such that, upon rotation of the actuator(s) relative to the housing from an un-actuated position to an actuated position, the closure member is urged into contact with the movable handle to urge the movable handle from an initial position to a compressed position, thereby moving the end effector assembly to an approximated position.

A surgical instrument includes a housing having a shaft extending distally therefrom, an end effector assembly disposed at a distal end of the shaft, a handle assembly coupled to the housing for manipulating the end effector assembly, a deployable assembly, at least one actuator for deploying and retracting the deployable assembly, and a closure member. The closure member is keyed to the actuator(s) and operably positioned relative to the movable handle of the handle assembly such that, upon rotation of the actuator(s) relative to the housing from an un-actuated position to an actuated position, the closure member is urged into contact with the movable handle to urge the movable handle from an initial position to a compressed position, thereby moving the end effector assembly to an approximated position.

Provided herein is a method of treating a traumatic brain injury in a subject in need thereof, the method including administering to the subject a therapeutically effective amount of radiation. The methods can improve motor function recovery and reverse motor function deficits after traumatic brain injury and/or ischemic stroke in a subject.

Disclosed are a triboelectric energy generator using an ultrasonic waves, and an implantable treatment device for suppressing spread of tumor including the triboelectric energy generator. The generator includes a substrate; a first triboelectric member disposed on the substrate; and a second triboelectric member disposed above and spaced apart from the first triboelectric member, wherein the first triboelectric member and the second triboelectric member are made of different materials, wherein when an ultrasonic wave is applied to a top face of the second triboelectric member, the second triboelectric member is constructed to alternately contact and non-contact the first triboelectric member, thereby to generate triboelectricity.

A device is designed to remove blockages in a lumen such as a thrombus, blood clot, or embolus. The device comprises a manipulating wire and a structure that can conduct electrical current to a lumen blockage. The electrical current is preferably in radio frequency (RF). The RF electric current in the blockage can excite the contents such as proteins of the blockage, so that cross-linking density and interfacial adsorption of the entire blockage is enhanced. The enhanced cross-linking density can result in increased fracture resistance of the blockage such that fracture of the blockage during the removal process is unlikely. The enhanced interfacial adsorption results in increased interfacial fracture resistance between the device and blockage so that the blockage can be securely captured during the removal process without using radially applied force.

The present disclosure provides methods and systems for limiting arcing during an electroporation procedure. A method includes delivering a calibration shock using a catheter, measuring a current delivered during the calibration shock and a voltage delivered during the calibration shock, calculating, using a processing device, a calibration shock impedance based on the delivered current and the delivered voltage, calculating, using the processing device, a bridge impedance based on the calibration shock impedance and a target impedance, wherein the bridge impedance is a difference between the calibration shock impedance and the target impedance, adding an impedance in series with the catheter, the impedance being greater than or equal to the bridge impedance, and delivering a therapeutic shock using the catheter in series with the added impedance.