Embodiments described herein are directed to a system for providing alternating freeze and thaw cycles. The system includes a controller, a vessel for holding a working fluid, a pressure generator, a cooler, a cooler heat exchanger, a heater, a heater heat exchanger, a check valve, and a treatment instrument. In some embodiments, the treatment instrument includes a distal end, a proximal end, a connecting portion adjacent to the proximal end, a needle element adjacent the distal end, a handle portion disposed between the proximal and distal end, and a depth-limiting element to limit an injection depth of the needle element.

A method of ablating tissue includes positioning a treatment device proximate to a target tissue area. The treatment device has an expandable treatment element. The expandable treatment element is inflated with a refrigerant during an inflation phase such that at least a portion of the expandable treatment element is in contact with the target tissue area. A first pressure measurement of the inflated expandable treatment element is recorded and compared to a predetermined pressure threshold. The refrigerant is circulated within the expandable treatment element during an ablation phase to reduce a temperature of the target tissue area to a temperature sufficient to cryoablate the target tissue area. A second pressure measurement of the expandable treatment element is recorded during the ablation phase and compared to the predetermined pressure threshold.

The cooling system cools a patient's tissue while applying suction to the skin and applying ultrasound waves to the tissue to reduce fat cells. The cooling applicator simultaneously provides suction, cooling, and ultrasound to the treatment area of the patient. The applicator connects to a suction to draw the tissue longitudinally into a cavity of the applicator. Cooling plates located laterally outward from the cavity cool the tissue during the treatment. A transducer located longitudinally above the cavity transmits ultrasound waves longitudinally downward into the cavity and the tissue. The ultrasound provides non-focused treatment such that the transducer transmits the ultrasound waves oriented horizontally and vertically longitudinally downward at the tissue. A treatment pad placed on the patient's skin directly contacts the patient such that the applicator does not directly contact the patient. The treatment pad is constructed from a fabric storing a glycerin gel, deionized water, and fructose.

A direct vision cryosurgical and methods of use are described herein where the device may generally comprise an elongated rigid structure with a distal end, a proximal end, and a central lumen. The distal end may comprise a non-coring optically transparent needle tip with at least one lateral fenestration in communication with the central lumen. The distal end may also house at least one imaging device configured for distal imaging. A proximal end of the device may comprise a handle with a means for connecting the imaging device(s) to an imaging display(s), and a means for accessing bodily tissue in the vicinity of the distal end with a cryo-ablation probe through the central lumen and the lateral fenestration(s) for diagnostic or therapeutic purposes.

A cryoablation catheter, comprising a balloon (1) and a delivery catheter (2) passing through the balloon (1). The delivery catheter (2) is provided with a fluid inflow cavity (21) and a fluid outflow cavity (22) therein. The fluid inflow cavity (21) extends into the balloon (1), and a side wall of the fluid inflow cavity (21) is provided with a spray head (211) that injects a liquid into the balloon (1). The spray head (211) has a number of spray holes (2111, 2112) circumferentially arranged on the exterior of the fluid inflow cavity (21). An end of the fluid outflow cavity (22) has a cross section (24) that seals the fluid outflow cavity (22), and a side wall of the fluid outflow cavity (22) is provided with a reflow hole (221) in communication with the balloon (1). A fluid flows from the fluid inflow cavity (21) through the nozzle holes (2111, 2112) into the balloon (1). The nozzle holes (2111, 2112) are evenly distributed outside the fluid inflow cavity (21), so that the interior of the balloon (1) is uniformly filled with the refrigeration fluid, ensuring the uniformity of heat exchange at each part of the balloon (1) in an axial direction. The fluid then flows out from the reflow hole (221). The structural design can effectively improve the heat exchange efficiency of the fluid, and the production and processing processes are relatively simple.

Methods and devices for treating nasal airways are provided. Such devices and methods may improve airflow through an internal and/or external nasal valve, and comprise the use of mechanical re-shaping, energy application and other treatments to modify the shape, structure, and/or air flow characteristics of an internal nasal valve, an external nasal valve or other nasal airways.

Systems and methods for assessing sympathetic nervous system (SNS) tone for renal neuromodulation therapy are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a detector attached to or implanted in a patient and a receiver communicatively coupled to the detector. The detector can measure cardiac data and the receiver and/or a device communicatively coupled thereto can analyze the cardiac data to provide one or more SNS tone indicators. The SNS tone indicators can be used to determine whether a patient will be responsive to a neuromodulation therapy and/or whether a neuromodulation therapy was effective.

A cryoadhesion apparatus includes a remote control assembly, a valve assembly, a needle catheter assembly, and a gas cylinder, the remote control assembly includes a sheath structure and a remote control, the sheath structure is provided with a catheter channel for the needle catheter assembly to pass through, two ends of the valve assembly are respectively connected to the needle catheter assembly and the gas bottle; the sheath structure is capable of squeezing the needle catheter assembly, when squeezing is maintained, the needle catheter assembly is capable of moving along with the sheath structure under a frictional force between an inner wall of the catheter channel and the needle catheter assembly; the remote control is configured to, when triggered, send a trigger signal to the valve assembly; the valve assembly is configured to transport, when receiving the trigger signal, a gas from the gas cylinder to the needle catheter assembly.

A system for laparoscopic thermal treatment of visceral fat includes an elongate cooling probe configured for placement through a trocar, the probe including an elongate shaft having a proximal end and a distal end and having a maximum transverse dimension, and an expandable endpiece having a proximal end and a distal end, and including a collapsed state configured for placement through a channel of the trocar and an expanded state, the expanded state having a maximum outer diameter, the maximum outer diameter at least about twice the maximum transverse dimension of the shaft, wherein the proximal end of the endpiece is sealingly coupled to the distal end of the shaft, and a heat exchanger coupled to the cooling probe and configured to remove heat from the endpiece such that adipose tissue placed in contact with the endpiece can be cooled to a temperature of between about 2° C. and about .sup.+1° C.

Systems and methods for controllable delivery of pressurized refrigerant to a medical device, such as a cryoablation catheter. In some examples, a delivery system includes a tank holding the pressurized refrigerant, an electrical heater arranged to heat the tank, and an electronic controller connected to regulate the heater based on input signals received from a plurality of sensors including a temperature sensor in thermal contact with the exterior surface of the tank and a pressure sensor for measuring pressure in the refrigerant-delivery line connecting the tank to the medical device. In operation, the electronic controller processes the input signals by comparing values of at least some of the input signals with respective threshold values and uses logic operations configured for combined processing of two or more of the input signals to decide when to switch the heater between an ON state and an OFF state.