Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

The invention relates to cylindrical tunable fluidic lenses. The cylindrical optical power of the lenses may be continuously tuned within at least ±10 diopters, without inducing any significant spherical aberration, or any other significant aberrations. The lenses feature a geometry that produces minimal or no spherical defocus. These cylindrical tunable fluidic lenses could be used to induce and/or correct cylindrical optical aberrations in adaptive optical systems, particularly in ophthalmologic applications related to objective and automatic assessment of the refractive error of the eye, without the need of receiving feedback from the subjects.

The disclosure provides an optical apparatus, comprising: a source of wavelength tunable laser light or a broad band partially coherent light source, a first beam splitter receiving the light and directing a part of the light to a sample arm as illumination light and another part of the light to a reference arm as reference light, the sample arm comprising: means for directing the illumination light via a first beam splitter as a light spot to a sample, wherein an image of the light spot is reflected from the sample, a focus tunable optics receiving the image of the light spot from the sample after being transmitted through the first beam splitter and focusing the image to a detection plane, wherein a photodetector unit is adapted for receiving the recombined light from the sample arm and the reference arm. Preferably, a computing unit is connected to the photodetector unit, wherein the computing unit is configured to digitize the signal and use digital techniques to calculate wavefront error at different planes, e.g. in the human eye.

A system for correcting vision in an eye that uses a premium, customized IOL, the system comprising: (1) optical aberrometer means for measuring wavefront aberrations of the eye; (2) computer means for designing a wavefront-customized correction profile for the IOL; (3) manufacturing means for creating a customized IOL with the wavefront-corrected profile; and (4) surgical means for implanting the customized IOL in the eye. Alternatively an uncorrected IOL is first implanted and aligned in the eye, followed by in-situ scanning a femtosecond laser spot across the implanted IOL to locally change an index of Refraction of the IOL material in-situ.

Methods, apparatus and systems for achieving efficient optical design are described. In one representative aspect, a method for optical design includes introducing a light source into the optical system. The light source emits illumination that is characterized as a point source, a collimated illumination, or a superposition of one or more point sources or one or more collimated illuminations. The light source is represented by a vector field comprising a plurality of vectors. The method also includes defining each optical surface of the optical system based on the vector field of the light source, tracing a plurality of rays that propagate from the light source, traverse through the optical system and reach a predetermined target or targets, and determining whether an illumination or an image characteristic at the predetermined target or targets meets preset design requirements.

Disclosed herein are methods and systems of evaluating test-retest precision using fractional rank precision or mean-average precision, comprising: a) collecting a test and a retest result of each subject, wherein the results are described in feature space(s) and collected from a vision test machine; b) selecting, a first test result of a first subject; c) calculating distances from the first test result to the retest result of each subject; d) assessing, a similarity between the first test result and the retest result of each subject by ranking the distances in a non-descending order; e) assessing a rank precision for the first subject based on a rank of a distance from the first test result to the retest result of the first subject; f) repeating b), c), d), and e) for each subject; and evaluating, the test-retest precision based on the rank precision for each of the plurality of subjects.

Disclosed herein are methods and systems of evaluating test-retest precision using fractional rank precision or mean-average precision, comprising: a) collecting a test and a retest result of each subject, wherein the results are described in feature space(s) and collected from a vision test machine; b) selecting, a first test result of a first subject; c) calculating distances from the first test result to the retest result of each subject; d) assessing, a similarity between the first test result and the retest result of each subject by ranking the distances in a non-descending order; e) assessing a rank precision for the first subject based on a rank of a distance from the first test result to the retest result of the first subject; f) repeating b), c), d), and e) for each subject; and evaluating, the test-retest precision based on the rank precision for each of the plurality of subjects.

A common beam scanning retinal imaging system comprises: a light source module (1), an adaptive optics module (2), a beam scanning module (3), a small field-of-view relay module (5), a large field-of-view relay module (6), a sight beacon module (9), a pupil monitoring module (7), a detection module (8), a control module (10) and an output module (11). The system can perform real-time correction of human eye aberration by adaptive optics technology, and realize the confocal scanning imaging function in a large field of view and the adaptive optics high-resolution imaging function in a small field of view simultaneously by the common beam synchronous scanning configuration combined with the two relay optical path structures for both the small field of view and the large field of view. The system can not only observe disease lesions in a wide range on the retina by the large field-of-view imaging, but also observe fine structures of the lesions by the small field-of-view high-resolution imaging. A variety of imaging images are acquired by common path optical beam scanning to meet the needs of different application scenes, which greatly expands the application range of the existing confocal imaging equipment.

An anisoplanatic aberration correction method and apparatus for adaptive optical linear beam scanning imaging. The method comprises: in an adaptive optical linear beam scanning imaging system, performing temporal correction on an anisoplanatic region aberration in a linear beam scanning direction, and performing regional correction on an anisoplanatic region aberration in a linear beam direction. According to the method, the limitation of an isoplanatic region on an adaptive optical imaging field of view can be overcome, and wide field of view aberration correction and high-resolution imaging of a retina is realized. According to the provided method and apparatus for temporal and regional correction of a wide field of view anisoplanatic aberration, the wide field of view aberration correction can be completed by means of only a single wavefront sensor and a single wavefront corrector, such that almost none of the system complexities is increased. The provided correction of an image subjected to deconvolution is low in cost. By means of regional deconvolution of wavefront aberration information, the adaptive optical aberration correction can be compensated to the greatest possible extent, the correction effect is good, and online processing or post-processing can be performed, and correction is flexible and convenient.