The present disclosure is directed to systems and methods for measuring and analyzing pupillary psychosensory responses. An electronic device is configured to receive video data with at least two frames. The electronic device then locates one or more eye objects in the video data and determine pupil and iris sizes of the one or more eye objects. The electronic device determines the pupillary psychosensory responses of the one or more eye objects by tracking a ratio of pupil diameter to iris diameter throughout the video. Several metrics for the pupillary psychosensory responses can be determined (e.g., velocity of change of the ratio, peak to peak amplitude of the change in ratio over time, etc.). These metrics can be used as measures of an individual's cognitive ability and mental health in a single session or tracked throughout multiple sessions.

The disclosure provides methods of managing opioid therapy, particularly, for pain management. The methods comprise determining in a subject, for example, a subject who has received an opioid treatment, pupillary unrest in ambient light (PUAL). Low values of PUAL can be used to identify patients at risk for opioid side-effects, such as opioid-related respiratory depression (OIRD), and who warrant attention to prevent such side effects. Accordingly, the methods include monitoring the patients having low values of PUAL for signs of adverse side-effects and/or limiting or avoiding administration of opioids.

A vision screening device for administering vision screening tests, and in particular a color vision screening test, to a patient is described herein. The vision screening device may include associated methods and systems configured to perform the operations of the vision screening tests. The device may include a first radiation source configured to generate color stimuli, a second radiation source separate from the first radiation source configured to emit near-infrared radiation, and a sensor configured to capture the near-infrared radiation emitted by the second radiation source, and reflected by an eye of a patient. The device may also be configured to cause color stimulus to be displayed to the patient, and determine measurement(s) of the eye of the patient in response to the color stimulus. The device may be further configured to analyze the measurements to generate a recommendation and/or diagnosis associated with the vision of the patient. The device may also be configured to display the recommendation and/or the measurements, along with additional screening data, to an operator conducting the vision test.

Provided herein are systems, devices and methods for monitoring the progression of, determining and/or assessing brain related conditions in a subject based on pupil light responses (PLRs) to focal central and peripheral chromatic light stimuli, in particular, by classifying the PLR based on one or more PLR parameter values, wherein the classifying allows monitoring the progression of, determining and/or assessing the brain related condition

A hand-held sized ocular and neurological screening device, system and method, the screening device comprising an eyepiece and a hand-held housing, the housing comprising a tubular stimulus chamber defining a light stimulus channel, wherein an illumination source is configured to provide light stimulus towards an opening through the light stimulus channel and an operational chamber comprising an infrared camera positioned outside the stimulus channel and inclined towards the opening, the infrared camera is configured to capture images of the pupils and eye movements through the opening without interfering with the light stimulus and a controller configured to receive the captured images from the infrared camera. The hand-held sized device can include a clip-on fixture for fixing the device onto a table, a desktop, or any portable ophthalmic apparatus.

A computer-implemented method is described. The method is be implemented by processors of an aircraft system. The method includes receiving images of an eye and a lighting configuration associated with a cockpit of an aircraft. The method further includes detecting a position of the eye within each of the images. The method further includes compensating for a pupillary light response of the eye based on the position of the eye within the image and the lighting configuration. By compensating for the pupillary light response, a fatigue level of the operator is estimated with reduced noise.

Systems and methods for predicting exposure to an agent. One or more features are extracted from physiological data. For each respective classifier, (i) the respective classifier is identified, wherein the respective classifier is trained using training data for a respective physiological state, (ii) the respective classifier is applied to the one or more features to obtain a classifier output that represents a likelihood of exposure, (iii) a respective first threshold is applied to the classifier output to determine a patient state classification, and (iv) the patient state classifications are aggregated across a number of time intervals to obtain an aggregate patient state classification for each classifier. The aggregate patient state classifications are combined across the plurality of classifiers to obtain a combined classification, and an indication that the patient has been exposed to the agent is provided when the combined classification exceeds a second threshold.

In one embodiment, a cognitive load driving assistant increases driving safety based on cognitive loads. In operation, the cognitive load driving assistant computes a current cognitive load of a driver based on sensor data. If the current cognitive load exceeds a threshold cognitive load, then the cognitive load driving assistant modifies the driving environment to reduce the cognitive load required to perform the primary driving task and/secondary task(s), such as texting via a cellular phone. The cognitive load driving assistant may modify the driving environment indirectly via sensory feedback to the driver or directly through reducing the complexity of the primary driving task and/or secondary tasks. In particular, if the driver is exhibiting elevated cognitive loads typically associated with distracted driving, then the cognitive load driving assistant modifies the driving environment to allow the driver to devote appropriate mental resources to the primary driving task, thereby increasing driving safety.

A system or method for measuring human ocular performance can be implemented using an eye sensor, a head orientation sensor, an electronic circuit and a display that presents one of virtual reality information, augmented reality information, or synthetic computer-generated 3-dimensional information. The device is configured for measuring saccades, pursuit tracking during visual pursuit, nystagmus, vergence, eyelid closure, or focused position of the eyes. The eye sensor comprises a video camera that senses vertical movement and horizontal movement of at least one eye. The head orientation sensor senses pitch and yaw in the range of frequencies between 0.01 Hertz and 15 Hertz. The system uses a Fourier transform to generate a vertical gain signal and a horizontal gain signal.

Accommodating ophthalmic devices including an ambient light sensor and an accommodation sensor and related methods of use are described. In an example, the accommodation sensor is configured to measure a biological accommodation signal of an eye on or in which the accommodating ophthalmic device is mounted. In an embodiment, the accommodating ophthalmic device is configured to measure the biological accommodation signals based on ambient light, such as based on an intensity or amount of ambient light, incident on the accommodating ophthalmic device. Such ambient light may be measured with the ambient light sensor.