The present disclosure is directed to systems and methods for measuring and analyzing pupillary psychosensory responses. An electronic device is configured to receive video data with at least two frames. The electronic device then locates one or more eye objects in the video data and determine pupil and iris sizes of the one or more eye objects. The electronic device determines the pupillary psychosensory responses of the one or more eye objects by tracking a ratio of pupil diameter to iris diameter throughout the video. Several metrics for the pupillary psychosensory responses can be determined (e.g., velocity of change of the ratio, peak to peak amplitude of the change in ratio over time, etc.). These metrics can be used as measures of an individual's cognitive ability and mental health in a single session or tracked throughout multiple sessions.

The disclosure provides methods of managing opioid therapy, particularly, for pain management. The methods comprise determining in a subject, for example, a subject who has received an opioid treatment, pupillary unrest in ambient light (PUAL). Low values of PUAL can be used to identify patients at risk for opioid side-effects, such as opioid-related respiratory depression (OIRD), and who warrant attention to prevent such side effects. Accordingly, the methods include monitoring the patients having low values of PUAL for signs of adverse side-effects and/or limiting or avoiding administration of opioids.

Aspects of the present disclosure provide techniques for quantitatively assessing tear-film dynamics associated with contact lenses. An example method includes projecting an image of one or more shapes on a tear film surface of the contact lens worn on the eye, capturing video data, comprising a plurality of image frames, of the one or more shapes projected on the tear film surface of the contact lens over a period of time, performing image segmentation on a plurality of reflection patterns included in the plurality of image frames, generating a plurality of maps of the tear film surface of the contact lens indicating changes to the tear film surface of the contact lens during the period of time, and outputting, based on the plurality of maps, one or more metrics quantifying the changes to the tear film surface of the contact lens over the period of time.

Method and contact lens (3) for measuring a subject's three dimensional eye movement including torsional movement. A video camera (1) is provided for recording an image of the subject's eye (2). The contact lens (3) is provided for placement over the subject's eye (2). The contact lens (3) comprises one or more markers (3a,3b) that are detectable by the video camera (1) and are positioned at a lateral offset (D) with respect to a central part (3p) of the contact lens (3). The one or more markers (3a,3b) are configured for detecting torsional rotation (R) of the subject's eye (2) around a line of sight axis (C) of the subject's eye (2) by using the video camera (1) to track a position of the one or more markers (3a,3b).

A hand-held sized ocular and neurological screening device, system and method, the screening device comprising an eyepiece and a hand-held housing, the housing comprising a tubular stimulus chamber defining a light stimulus channel, wherein an illumination source is configured to provide light stimulus towards an opening through the light stimulus channel and an operational chamber comprising an infrared camera positioned outside the stimulus channel and inclined towards the opening, the infrared camera is configured to capture images of the pupils and eye movements through the opening without interfering with the light stimulus and a controller configured to receive the captured images from the infrared camera. The hand-held sized device can include a clip-on fixture for fixing the device onto a table, a desktop, or any portable ophthalmic apparatus.

In a laser cataract procedure that also corrects for astigmatism, an iris registration method compares an iris image of a patient's eye taken when the eye is not docked to a patient interface device with an iris image of the same eye that is docked to the patient interface, to calculate a rotation angle between the two images. The astigmatism axis of the eye is measured when the eye is not docked, and the measured axis is rotated by the calculated rotation angle to obtain a rotated astigmatism axis relative to the iris image of the docked eye. The laser cataract procedure is performed based on the rotated astigmatism axis. The rotation angle is calculated by optimizing a transformation that transforms the undocked iris image to match the docked iris image, where the transformation includes a dilation factor that accounts for different pupil dilation of the two iris images.

Systems and methods for improving the peripheral vision of a subject are disclosed. In one aspect, embodiments of the present disclosure includes a method, which may be embodied on a system, for improving peripheral vision of a subject using a visual marker on a display screen, the method includes, displaying a peripheral target on the display screen, the peripheral target having a visually discernable characteristic and determining whether the subject is able to correctly identify the peripheral target displayed on the display screen using the peripheral vision. The visual marker is intended for viewing using central vision of the subject and the peripheral target is intended for identification using the peripheral vision of the subject.

The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.

Optical sensors, systems and methods of use thereof are provided. Aspects of the subject systems include a sensor having a sensing surface and a configuration that directs a first optical signal to interact with the sensing surface at a first incident angle, and directs a second optical signal to interact with the sensing surface at a second incident angle. The subject sensors, systems and methods find use, e.g., in the diagnosis of dry eye disease.

An apparatus for screening, treatment, monitoring and/or assessment of visual impairments, comprising electronic means for simultaneously applying two separate and unrelated processing methods to images presented to a patient's eyes: a first processing method being applied to an non-amblyopic eye (the eye with the better vision), and a second processing method being applied to an amblyopic eye (the weaker eye, or the impaired eye). A method for screening, treatment, monitoring and/or assessment of visual impairments, comprising: a. defining a starting point, wherein differences between a patient's eyes are completely, or as closely as practically possible, corrected, to enable two identical or similar images to be transferred to the brain from the patient's eyes; b. defining an ending point, wherein there is no correction applied to any of the patient's eyes; c. defining a screening, treatment, monitoring and/or assessment plan, for initially applying correction to images according to the starting point, then gradually reducing the correction, at a controlled and predetermined rate, towards the ending point; and d. applying the plan to images presented to the patient's eyes, while monitoring patient's performance.