The length of an optical fiber from a portion aligned with the rear end of an insertion needle to a fixing portion is a length obtained by adding a predetermined extra length to a linear distance between the rear end of the insertion needle in a case where the insertion needle is located at a protruding position (insertion position) and an optical fiber fixing position of a grip portion. There is provided a fiber feeding adjustment mechanism that suspends the optical fiber with a first suspension portion and a second suspension portion so as to make a detour in a state in which there is no slack, and changes the detour length continuously according to the movement of the insertion needle in a case where the insertion needle moves between the retracted position and the protruding position, thereby maintaining a state in which the optical fiber is suspended without slack.

In a biopsy needle having a hollow tubular outer needle, an inner needle that is disposed in a hollow portion of the outer needle so as to be movable in the tube axis direction relative to the outer needle, and a recessed sample collection portion that is cut inward from a circumferential surface of the inner needle, an inner hole that extends in the longitudinal direction of the inner needle on each of the inner needle distal end side and the inner needle rear end side of the sample collection portion and are opened to the sample collection portion is provided in the inner needle, and a light guide member is disposed in the inner holes. At least a part of the light guide member is fixed by filler filled in the inner holes.

An apparatus according to an aspect of the present invention includes a first obtaining unit configured to obtain an ultrasound image generated by transmitting and receiving ultrasonic waves to and from an object, a display control unit configured to control a display unit to display the ultrasound image, a second obtaining unit configured to obtain a photoacoustic signal generated by receiving photoacoustic waves generated from light irradiated to the object, and a saving control unit configured to obtain information representing a save instruction given when the ultrasound image is being displayed, and configured to save in a storage unit the ultrasound image corresponding to a time point of the save instruction and information derived from the photoacoustic signal based on the information representing the save instruction.

A wavefront control apparatus includes a detector configured to detect a signal generated from a medium onto which light is irradiated, and a controller configured to control a wavefront of the light based on an output of the detector. The controller performs first processing for forming a first wavefront of the light based on the signal generated from a first measurement position in the medium, and second processing for forming a second wavefront of the light based on the signal generated from a second measurement position different from the first measurement position in the medium onto which the light having the first wavefront is irradiated.

A system, method, and wireless earpieces for determining the status of the user. Sensor measurements of the user are performed utilizing a radar sensor of the wireless earpieces. The sensor measurements are analyzed. The status of the user is determined utilizing at least the sensor measurements of the radar sensor of the wireless earpieces. An alert is communicated to the user in response to there being a change in the status of the user.

A photoacoustic image evaluation apparatus includes a processor configured to acquire a first photoacoustic image generated at a first point in time and a second photoacoustic image generated at a second point in time before the first point in time, the first and second photoacoustic images being photoacoustic images generated by detecting photoacoustic waves generated inside a subject, who has been subjected to blood vessel regeneration treatment, by emission of light into the subject; acquire a blood vessel regeneration index, which indicates a state of a blood vessel by the regeneration treatment, based on a difference between a blood vessel included in the first photoacoustic image and a blood vessel included in the second photoacoustic image; and display the blood vessel regeneration index on a display.

The systems, devices, and methods herein make optoacoustic measurements and correct or normalize them for variations in optical energy level of the different light pulses used. An optical source directs optical pulses to tissue, an optical energy meter measures the optical energy of the different optical pulses, an acoustic detector measures an acoustic response generated by the tissue in response to the optical pulses, and a processor calculates a concentration of an analyte based on the measured acoustic response and as corrected or normalized for the different energy levels among the optical pulses.

A photoacoustic remote sensing system for imaging a subsurface structure in a sample, comprising exactly one laser source configured to generate a pulsed or intensity-modulated excitation beam configured to generate ultrasonic pressure signals in the sample at an excitation location, and an interrogation beam incident on the sample at the excitation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic pressure signals, an optical system configured to focus the excitation beam and the interrogation beam below a surface of the sample, a detector configured to detect the returning portion of the interrogation beam, and a processor configured to calculate an image of the sample based on a detected intensity modulation of the returning portion of the interrogation beam from below the surface of the sample.

Certain embodiments describe a system, method, and apparatus for multi-spectral photoacoustic imaging. A method, for example, can include receiving multi-spectral photoacoustic image data from a photoacoustic imaging system. The method can also include pre-processing the multi-spectral photoacoustic image data. The pre-processing can comprise determining a number of significant components above a noise floor of the multi-spectral photoacoustic image data. In addition, the method can include detecting tissue chromophores based on the number of significant components from the multi-spectral photoacoustic image data using an unsupervised spectral unmixing process. The unsupervised spectral unmixing process can include clustering and windowing of the multi-spectral photoacoustic image data. The method can further include displaying the detected tissue chromophores in an abundance map.

Methods, Apparatuses, and Systems of operating a laser atherectomy system to perform an endoscopic atherectomy procedure within a vessel at a therapeutic region of an anatomical condition by use of an atherectomy laser device coupled to an ultrasound imaging probe. The atherectomy laser device operates to generate photoacoustic signals from a light source of the atherectomy laser device to for guidance within the vessel and to characterize tissue about the therapeutic region by delivery of pulsed wavelengths within the vessel, and to perform operations of tissue ablation directed to the anatomical condition. This enables guidance of the atherectomy laser device by feedback from the viewing of photoacoustic images based on photoacoustic signals generated the atherectomy laser device and created in response to changes in acoustic intensity due to changes of optical wavelength monitored by the ultrasound imaging probe.