Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

A sheet-shaped oral appliance is provided that is detachably attached to an oral body device and includes a functional portion with a sensor unit that acquires information in an oral cavity and an energy irradiation unit that radiates energy into the oral cavity, an electrical connection portion, and a wiring portion that connects at least one of the sensor unit and the energy irradiation unit to the electrical connection portion. The functional portion, the connection portion, and the wiring portion are formed by a wiring layer having first and second main surfaces that oppose each other, a first insulating layer arranged on the first main surface and a second insulating layer arranged on the second main surface. Moreover, in the functional portion, a thickness of the first insulating layer is smaller than a thickness of the second insulating layer.

Methods and apparatuses for monitoring either or both the performance of an orthodontic appliance for repositioning a patient's teeth and/or the user compliance in wearing the appliance using a biosensor. The apparatuses described herein may include one or more sensors, including biosensors, electrical sensors, or both, configured to generate sensor data related to user compliance and/or repositioning of the patient's teeth by an orthodontic appliance.

A system and apparatus for the collection of serous or serosanguinous fluid from a percutaneous site after surgery. A pump unit with one or more pumps or powered sources provide continuous negative pressure suction to draw fluid from the percutaneous site and pumps the fluid into disposable reservoirs with one-way valves that are easy to handle while maintaining sterility and a seal to prevent the loss of vacuum. Air is continuously removed from the reservoirs. Measurement and analysis of the output is performed automatically. Additionally, through such a peristaltic pump device, controlled collection of measured surgical and/or bodily fluid from a subject patient may be undertaken allowing for more effective and closer analysis, as well.

A device for measuring the turbidity of cerebrospinal fluid includes, a source of a light signal comprising having one or more wavelength(s), such that at least part of the emitted light signal passes through the cerebrospinal fluid; a flow element including an inlet and an outlet, the flow element being suitable for allowing cerebrospinal fluid to flow between the inlet and the outlet; an opaque element, arranged to absorb at least part of the emitted light signal after it has passed through the cerebrospinal fluid, and to allow another part of the emitted light signal to be reflected after it has passed through the cerebrospinal fluid; and an optical detector configured to detect the light signal after it has passed through the cerebrospinal fluid.

Several embodiments and methods are described for draining a lymphatic system for therapeutic purposes. The lymphatic draining can be performed by removal of fluid from the lymphatic system via a needle, a catheter, an access port, a reservoir, a shunt, or a combination of these devices. The drainage devices can be configured for use during only a single procedure or for reoccurring procedures.

The invention relates to a respiratory secretion sample collection device that includes a collection reservoir for directly receiving a sample of a respiratory secretion, a displacement member for insertion into the collection reservoir and displacing the sample within the collection reservoir, a container of a diluent for fluid communication with the sample for mixing the diluent with the sample, and an outlet for discharging the mixture of the diluent and the sample to an assay device. In embodiments, the precise volumes of the sample and the diluent are effectively mixed to enable the conduct of assays for which the relative concentration of diluent and sample is critical.

Described herein are devices and methods for continuous real time monitoring of kidney function. In various embodiments, a urine analysis device collects sensor data describing one or more properties of urine. The urine analysis device may be integrated with a catheter system to continuously generate sensor data in real time as the urine is collected by the catheter system. Sensor data collected by the urine analysis device may be analyzed by physicians to detect changes in a patients kidney function. If necessary, based on the sensor data, physicians may perform an intervention to improve a patients kidney function.

Improved assessment of brain injuries, and improved brain injury management, is achieved using a combination of impact-related data derived from instrumented mouthguard devices, human function performance testing, and biomarkers derived from biological fluid (such as saliva and/or blood). The human function performance testing may include brain function performance testing, and/or other forms of human function performance testing. This involves combining a data-driven understanding of a head impact event (based on data collected via an instrumented mouthguard device) with a data-driven understanding of human function performance following that head impact event. The biomarkers may include salivary mRNA and/or ncRNA, and/or blood proteins (for example via a FDA-approved Brain Trauma Indicator test).

A system and method is provided for monitoring a biological substance in a bodily orifice. The system includes a wearable device configured to be worn in a bodily orifice. A biosensor is carried by the wearable device and is constructed and arranged to obtain raw data regarding a biological substance in the orifice. The biosensor includes a processor circuit to provide processed data from the raw data, and a transmitter to wirelessly transmit the processed data to a second device.