Methods and devices treating an autonomic nervous system associated disease condition in a subject are provided. Aspects of the invention include inducing one or more physiological response selected from the group consisting of sweating, gastric emptying, enhanced heart rate variability and enhanced quantitative sensory test responsiveness in a manner sufficient to modify the autonomic nervous system so as to treat the subject for the disease condition. The methods and devices find use in a variety of applications, e.g. in the treatment of subjects suffering from conditions arising from disorders of the autonomic nervous system.

A new system monitors ethanol alcohol levels of a vehicle operator by collecting sweat from the operator's hands, and detecting the presence, if any, of ethanol in the sweat. The system can then be used, if ethanol is present, to take action, such as immobile vehicle disablement, in the event of intoxication caused by an impermissibly high levels of ethanol of the operator. The system includes devices, referred to as pods in the description, which are sweat-collecting devices that are attached to the steering wheel of the vehicle. If the measurable ethanol in collected moisture from the operator's hands exceeds a preset threshold, the system could be configured to warn the operator to park the vehicle thereafter to disable operation of the vehicle, but if the operator does not so discontinue operation of the vehicle hazard warning lights and audible warnings within and without the vehicle will be activated alerting near vehicles of a dangerous vehicle being operated in close proximity. Likewise the new system monitors for pulse rate and oxygen levels of the operator can be used to recommend operator action when the pulse rate and/or oxygen levels are outside of the normal range for an operator. When the pulse rate and or oxygen levels of the system are outside of the normal parameters for an operator, the system will warn the operator to park the vehicle and thereafter to disable operation of the immobile vehicle, but if the operator does not so discontinue operation of the vehicle the hazard warning lights, on board video, and audible warnings within and without the vehicle will be activated alerting near vehicles of a dangerous vehicle being operated in close proximity, and alarms will be sent to real time recording and monitoring devices.

A wearable monitoring system includes a first flexible substrate encapsulating a current ramping system to provide a current to an electrode in direct contact with a predetermined location of skin of a user to promote bodily fluid secretion, and a second flexible substrate placed over the predetermined location, the second flexible substrate having an integrated electrochemical sensor to determine bodily fluid concentration levels secreted through the skin.

A wearable medical device for collecting a biofluid and related methods are disclosed. The device has a patch adapted to removably couple to a user's skin. The patch has at least one flow channel, at least one sample chamber, and at least one biomarker detection chamber. The flow channel and/or the sample chamber conducts the biofluid towards the biomarker detection chamber. The sample chamber is adapted to create a high humidity environment adjacent the user's skin. The flow channel comprises a hydrophobic material and a hydrophilic material.

The invention provides systems and methods for tissue-mounted photonics. Devices of some embodiments implement photonic sensing and actuation in flexible and/stretchable device architectures compatible with achieving long term, mechanically robust conformal integration with a range of tissue classes, including in vivo biometric sensing for internal and external tissues. Tissue-mounted photonic systems of some embodiments include colorimetric, fluorometric and/or spectroscopic photonics sensors provided in pixelated array formats on soft, elastomeric substrates to achieve spatially and/or or temporally resolved sensing of tissue and/or environmental properties, while minimize adverse physical effects to the tissue. Tissue-mounted photonic systems of some embodiments enable flexible passive or active optical sensing modalities, including sensing compatible with optical readout using a mobile electronic devices such as a mobile phone or tablet computer.

An electronic ankle monitor, a process for a control unit of an electronic ankle monitor, as well as to a process for detecting alcohol in sweat are provided. The electronic ankle monitor (10) includes an electrochemical sensor (11) and an electrically operated heating element (12) for heating skin (20) in an area around the electrochemical sensor.

A device (100) for sensing a first analyte in sweat on skin includes an analyte-specific sensor (120) for sensing the first analyte and an active sweat coupling component (130) for transporting at least one sweat sample inside the device (100) and into fluid communication with the analyte-specific sensor (120). A method of sensing a first analyte in sweat on skin includes actively transporting at least one sweat sample into fluid communication with an analyte-specific sensor (120) for sensing the first analyte using an active sweat coupling component (130) and sensing the first analyte using the analyte-specific sensor (120).

This invention discloses a sensor for measuring parameters of sweat from a skin, comprising a flexible structure comprising a fluid passage having inlet and outlet, the flexible structure being detachably attached to the skin and configured such that sweat enters the inlet as the sweat releases from the skin and flows through the fluid passage into the outlet; a thermal actuator disposed on the flexible structure over the fluid passage and configured to operably provide heat to flow of the sweat through the fluid passage; a first thermistor disposed on the flexible structure over the fluid passage between the inlet and the thermal actuator and configured to operably measure a first temperature of the sweat thereon; and a second thermistor disposed on the flexible structure over the fluid passage between the thermal actuator and the outlet and configured to operably measure a second temperature of the sweat thereon.

Personal diagnostic devices including diagnostic patches (bio-patches) and interactive medical bracelets (bio-bracelets) are provided with a skin/patch interface, at least one analysis layer, a signal processing layer, and a user output interface. Embodiments of the interactive diagnostic devices may include micro-fluidic circuits with reaction chambers, analysis chambers, mixing cambers, and various pre-disposed chemistries or reagents for performing a wide verity of tests by transdermal transport of blood or perspiration. Sample collection chambers for the fluidic circuit may include minimally invasive tubules that penetrate the skin surface to acquire blood samples from capillaries near the epidermis. Alternate implementations of the personal diagnostic device may be equipped with logic processing, input/output devices, acoustic microphones, cryogenic circuits, embedded processors, electrical control circuitry, and battery current sources or photovoltaic sources of electrical power.

A wearable passive sweat detection device includes at least one detection sensor that includes: a base plate; a sensing element provided on the base plate, the sensing element including a sweat collection portion and a sweat self-driven detection portion, the sweat collection portion being configured to collect sweat discharged by sweat glands of skin, the sweat self-driven detection portion including a guide portion of a semi-conical structure, a test electrode provided on an outer conical surface of the guide portion, and a back electrode, and a narrow end of the guide portion facing the sweat collection portion; and a test element connected with the test electrode and back electrode. The adoption of the conical structure achieves a liquid-solid friction effect to realize passive detection of sweat components; meanwhile, flexibility is realized to facilitate wearing; by using different ion selective films, different ion concentrations can be detected; detection precision is high.