A device for reducing foreign body response in a subject caused by an electrode implanted in a subject's tissue. A base is secured to the subject, having a base aperture in proximity to the target site. The base can receive and align a body thereon. A body contains a chamber extending between a chamber aperture, aligned with the base aperture, at one end and a chamber opening at an opposite end. The chamber contains an acoustic coupling medium, such as polyvinyl alcohol cryogel, transmits acoustic vibrations from a transducer without altering their frequency. The transducer is mounted to the device and is configured to transmit acoustic vibrations into the chamber and through said acoustic coupling medium to the subject tissue at the target site, creating an acoustic field in the target site sufficient to reduce foreign body response in the subject where the electrode contacts the target tissue.

Disclosed are a probe integrated with an organic light source and a manufacturing method thereof. An organic light source integration method includes forming a first thin film encapsulation layer on a probe shank, depositing a first electrode in a first region on the first thin film encapsulation layer, depositing an insulating layer in a second region on the first thin film encapsulation layer, depositing a light emitting layer on the first electrode and the insulating layer, depositing a second electrode on the light emitting layer, and forming a second thin film encapsulation layer on the second electrode.

Disclosed are a probe integrated with an organic light source and a manufacturing method thereof. An organic light source integration method includes forming a first thin film encapsulation layer on a probe shank, depositing a first electrode in a first region on the first thin film encapsulation layer, depositing an insulating layer in a second region on the first thin film encapsulation layer, depositing a light emitting layer on the first electrode and the insulating layer, depositing a second electrode on the light emitting layer, and forming a second thin film encapsulation layer on the second electrode.

A closed-loop implantable neurostimulator system for mitigating chronic pain, the closed-loop implantable neurostimulator system including a neuromodulation device comprising one or more electrodes configured to measure a physiological signal of a subject and deliver an electrical stimulation signal to a target area in the subject and a controller, in communication with the one or more electrodes, comprising a processor and a computer-readable memory storing a trained healthy computer model, the controller configured to analyze the physiological signal that is measured using the trained healthy computer model to identify a corrective electrical stimulation signal that, when delivered by the one or more electrodes to the target area, reduces pathological neuronal events in the target area while preserving acute pain response.

An electrode configured for use in electromyography procedures including a shaft having a first end and a second end, where the shaft consists of a conductive material; an electrically insulative first coating configured to encase the conductive material; a tapered tip at the first end of the shaft, where the tip is angled and is formed by removing the first coating from a first portion of the shaft and exposing a first length of conductive material; and a hub positioned at the second end of the shaft, wherein the hub is positioned after removing the first coating from a second portion of the shaft and exposing a second length of conductive material, wherein the hub is configured to electrically couple a lead wire to the second length of conductive material at the second end.

An electrode configured for use in electromyography procedures including a shaft having a first end and a second end, where the shaft consists of a conductive material; an electrically insulative first coating configured to encase the conductive material; a tapered tip at the first end of the shaft, where the tip is angled and is formed by removing the first coating from a first portion of the shaft and exposing a first length of conductive material; and a hub positioned at the second end of the shaft, wherein the hub is positioned after removing the first coating from a second portion of the shaft and exposing a second length of conductive material, wherein the hub is configured to electrically couple a lead wire to the second length of conductive material at the second end.

The present invention relates to a suction instrument, more particularly a bipolar mapping suction instrument, for surgical purposes and to a system for suctioning fluids and tissue and for monitoring nerve tissue. The suction instrument comprises a cannula unit, which comprises an electrically conductive outer cannula tube, an electrically conductive inner cannula tube, and insulation. The electrically conductive inner cannula tube is electrically connected to a first pole of the bipolar electrical connection of the second interface. The electrically conductive inner cannula tube is arranged concentrically in the outer cannula tube which optionally can be insulated from the exterior. The electrically conductive inner cannula tube is mechanically connected to the handpiece and/or the first interface. The electrically conductive outer cannula tube is electrically connected to a second pole of the bipolar electrical connection of the second interface. The insulation is concentrically arranged between the outer cannula tube and the inner cannula tube. The insulation is configured to fully electrically isolate the outer cannula tube and the inner cannula tube in relation to one another.

A proto-microelectrode, a proto-microelectrode bundle and array, a method of manufacture of the proto-microelectrode, and a method of using the proto-microelectrode, the proto-microelectrode being capable of forming a microelectrode upon implantation into soft tissue, and includes an oblong electrode body; an optional first coat of electrically non-conducting material on the electrode body; a second coat of water insoluble flexible polymer material enclosing, at a distance, the electrode body and the first coat, the second coat including one or more through openings; a first layer of ice disposed between the electrode body and the second coat.

Disclosed herein are novel 3D microelectrode arrays (3D MEA) that include a substrate body (e.g. chip), microneedles, traces, and a well, wherein the 3D MEA provides for transfer of electrical signals on one side of the substrate body to the other side of the substrate body. Methods for using 3D MEAs to grow electrogenic cells and obtain electrophysiological signals are disclosed as well. Fabrication techniques for producing the 3D MEAs are also disclosed.

A device and a method for acquiring brain electrical signal. The device for acquiring brain electrical signal includes a plurality of electrodes and an electrode base. The electrode base is provided with a plurality of screw holes, and each of the plurality of electrodes passes through a corresponding screw hole of the plurality of screw holes.