In accordance with some non-limiting examples of the disclosed subject matter, an ingestible system configured to acquire physiological information from an interior of a subject is provided, comprising a substrate and at least one physiological sensor. The at least one “physiological sensor can be coupled to the substrate and configured to capture physiological data from at least one of an internal area or an orientation in a digestive tract of the subject. The system can include a controller coupled to the substrate and configured to receive the physiological data and prepare the physiological data for one of transmission from the subject or analysis of the physiological data. The substrate, including the at least one physiological sensor and the controller coupled thereto can be configured to self-orient within the digestive tract of the subject, during ingestion of the system by the subject.

In accordance with some non-limiting examples of the disclosed subject matter, an ingestible system configured to acquire physiological information from an interior of a subject is provided, comprising a substrate and at least one physiological sensor. The at least one “physiological sensor can be coupled to the substrate and configured to capture physiological data from at least one of an internal area or an orientation in a digestive tract of the subject. The system can include a controller coupled to the substrate and configured to receive the physiological data and prepare the physiological data for one of transmission from the subject or analysis of the physiological data. The substrate, including the at least one physiological sensor and the controller coupled thereto can be configured to self-orient within the digestive tract of the subject, during ingestion of the system by the subject.

Devices, systems and methods useable for useable for monitoring a physiological variable in a target tissue or body fluid located within the thorax of a subject by optical spectroscopy.

Methods and systems for position determination are described for using an intrabody probe having a plurality of electrodes to generate a plurality of different electrical fields, and to also measure, using the plurality of electrodes, a measurement set (a V.sub.e-e measurement set) comprising a plurality of measurements of the plurality of different electrical fields while the probe remains in one position. From the V.sub.e-e measurement set, spatial position coordinates for the intrabody probe are estimated within an intrabody coordinate system, using an established mapping between previously observed V.sub.e-e measurement sets and positions in the intrabody coordinate system. Systems and methods for generating and selecting such mappings are also described.

Methods and systems for position determination are described for using an intrabody probe having a plurality of electrodes to generate a plurality of different electrical fields, and to also measure, using the plurality of electrodes, a measurement set (a V.sub.e-e measurement set) comprising a plurality of measurements of the plurality of different electrical fields while the probe remains in one position. From the V.sub.e-e measurement set, spatial position coordinates for the intrabody probe are estimated within an intrabody coordinate system, using an established mapping between previously observed V.sub.e-e measurement sets and positions in the intrabody coordinate system. Systems and methods for generating and selecting such mappings are also described.

A system and method for monitoring a patient's compliance with a medication regimen includes an electronic tag having an antenna and a receiver/transmitter positioned with a medication capsule, and a reader positioned externally for detecting the presence and location of the tag in the patient.

Methods and apparatus for accessing and monitoring the gastrointestinal tract are described herein. One variation of a feeding tube system may generally comprise a gastric access device having a length, a controller in communication with the gastric access device, and one or more impedance or conductivity sensors positioned along the length and one or more temperature sensors positioned along the length. The controller may be configured to receive a first signal associated with the impedance or conductivity sensors and a second signal associated with respiration and determine whether a placement of the gastric access device is within a stomach of the subject.

A method for creating a conductive junction in a system for performing a diagnostic or therapeutic procedure includes placing a first elongate conductor through a first lumen of an elongate body, creating a hole in a wall of the elongate body adjacent the first lumen at a distal portion of the elongate body, applying an electrically conductive material to a portion of an outer circumference of the elongate body at the distal portion of the elongate body to form an electrode, and electrically coupling the first elongate conductor to the electrode.

In some embodiments, a body cavity shape of a subject is reconstructed based on intrabody measurements of voltages by an intrabody probe (for example, a catheter probe) moving within a plurality of differently-oriented electromagnetic fields crossing the body cavity. In some embodiments, the method uses distances between electrodes as a spatially calibrated ruler. Positions of measurements made with the intrabody probe in different positions are optionally related by using spatial coherence of the measured electromagnetic fields as a constraint. Optionally, reconstruction is performed without using a detailed reference (image or simulation) describing the body cavity shape. Optionally, reconstruction uses further information to refine and/or constrain the reconstruction; for example: images, simulations, additional electromagnetic fields, and/or measurements characteristic of body cavity landmarks. Optionally, reconstruction accounts for time-dependent cavity shape changes, for example, phasic changes (e.g., heartbeat and/or respiration), and/or changes in states such as subject hydration, edema, and/or heart rate.

A medical imaging system employs a transesophageal probe (20) including an ultrasound transducer (21) for scanning a patient's heart and atrial electrode(s) (22) for generating atrial electrocardiogram signal(s) predominately indicative of electrical activity of atrium chambers of the patient's heart. The medical imaging system further employs ventricular electrode(s) (23) for generating ventricular electrocardiogram signal(s) predominately indicative of electrical activity of ventricle chambers of the patient's heart. The medical imaging system further employs an electrocardiogram machine (30) for generating an electrocardiogram waveform based on the indicated electrical activities of the patient's heart, and for generating a cardiac gating signal representative of a cyclical cardiac phase period of the electrocardiogram waveform. The medical imaging system further employs an ultrasound machine (40) for reconstructing an ultrasound image of the patient's heart encompassing a time segment or an entirety of the cyclical cardiac phase period.