A device for reducing foreign body response in a subject caused by an electrode implanted in a subject's tissue. A base is secured to the subject, having a base aperture in proximity to the target site. The base can receive and align a body thereon. A body contains a chamber extending between a chamber aperture, aligned with the base aperture, at one end and a chamber opening at an opposite end. The chamber contains an acoustic coupling medium, such as polyvinyl alcohol cryogel, transmits acoustic vibrations from a transducer without altering their frequency. The transducer is mounted to the device and is configured to transmit acoustic vibrations into the chamber and through said acoustic coupling medium to the subject tissue at the target site, creating an acoustic field in the target site sufficient to reduce foreign body response in the subject where the electrode contacts the target tissue.

Electrode devices are provided having certain thin film components, including at least one thin film contact and a temperature sensor associated with the contact. The temperature sensor can be used to monitor the temperature during use of the electrode device, including during electrical stimulation or ablation. Further, the temperature sensor can be used to identify the most effective temperature for stimulation or ablation.

Methods and systems implement a variety of sensors, including in embodiments various combinations of EEG sensors, biochemical sensors, photoplethysmography (PPG) sensors, microphones, and accelerometers, to detect, predict, and/or classify various physiological events and/or conditions related to epilepsy, sleep apnea, and/or vestibular disorders. The events can include neuroelectrical events, cardiac events, and/or pulmonary events, among others. In some cases, the method and systems implement trained artificial intelligence (AI) models to detect, classify, and/or predict. The methods and systems are also capable of optimizing a treatment window, suggesting treatments that may improve the overall well-being of the patient (including improving pre- or post-event symptoms and effects), and/or interacting with various care providers.

Systems and methods of controlling a device using detected changes in a neural-related signal of a subject are disclosed. In one embodiment, a method of controlling a device or software application comprises detecting a first change in a neural-related signal of a subject, detecting a second change in the neural-related signal, and transmitting an input command to the device upon or following the detection of the second change in the neural-related signal. The neural-related signal can be detected using a neural interface implanted within a brain of the subject.

The present invention relates to a syringe-injection-type brain signal measurement and stimulation structure, and a syringe injection method therefor, and provides a structure including a high-performance flexible element capable of minimizing a skull opening when inserted into the brain. Particularly, the present invention comprises: a flexible element, which includes a contact part making contact with a surface of a cortex so as to measure a signal generated in the brain or transmit an external stimulus to the brain, a transmitting/receiving part positioned between a skull and a skin, and a connection part for making a connection between the contact part and the transmitting/receiving part; and an integrated circuit connected to the transmitting/receiving part so as to transmit/receive a signal.

Embodiments of the disclosure are drawn to implantable stimulator with machine learning based classifier. An implantable system includes sensors which provide sensor information to an implantable unit. The implantable unit uses a classifier on the sensor information to select a stimulation procedure which is applied via a stimulation electrode. The classifier may be generated by a trained machine learning model. The classifier may be trained on an external unit which is not implanted in the subject. The classifier may be trained based on sensor information from the implanted sensors as well as symptom information.

An implantable electrode device includes a carrier made of a polymer material, at least one measurement electrode formed by an electrically conducting pad located on the carrier, wherein the electrically conducting pad has a contact surface, a barrier layer enclosing the carrier by covering all surfaces of the carrier, wherein the contact surface of the electrically conducting pad is exposed to an outside environment, at least one electrically conducting trace, and at least one electrically conducting terminal. The electrically conducting trace can electrically connect the measurement electrode to the electrically conducting terminal. A surface of the implantable electrode device on a side on which the measurement electrode is located can have a maximum valley depth or a maximum peak height between the contact surface of the measurement electrode and a meanline of a surface of the implantable electrode device, excluding measurement electrodes, being equal to or smaller than 100 micrometres.

A device and a method for acquiring brain electrical signal. The device for acquiring brain electrical signal includes a plurality of electrodes and an electrode base. The electrode base is provided with a plurality of screw holes, and each of the plurality of electrodes passes through a corresponding screw hole of the plurality of screw holes.

An electrode system for an intracranial electroencephalogram is described. A substrate is configured to be applied directly on a brain of a patient. The substrate has a profile that is suitable to be placed within a subdural space in between a portion of intact cranium and cerebral cortex of the brain. A tracking device is arranged on the substrate. A plurality of electrodes are configured to sense electrical activity associated with the brain. Each of the plurality of electrodes has a predefined relationship with the tracking device. A tracking system is operable to determine a position of the tracking device relative to a reference point based on a strength of an electromagnetic field relative to the tracking device. A controller is configured to selectively determine a position for each of the plurality of electrodes based on the position of the tracking device and the predefined relationship.

The present disclosure provides systems and methods related to electroencephalography (EEG) electrode arrays. In particular, the present disclosure provides systems and methods relating to the manufacture and use of high-resolution electrocorticography (ECOG) electrode arrays and stereoelectroencephalography (SEEG) electrode arrays having various combinations and arrangements of microelectrodes and macroelectrodes for recording and modulating nervous system activity.