A method of treating CTCL comprising applying a combination of an effective amount of hypericin together with a form of visible light photodynamic therapy. Preferably, the effective amount of hypericin is an ointment comprising less than 1% hypericin. More preferably, the form of photodynamic therapy comprises an administration of escalating doses of visible light. Optionally, the escalating doses of visible light starts at about 5 J/cm.sup.2 and increases to a maximum dose of about 12 J/cm.sup.2.

The present invention relates to a uterine cervical image acquisition apparatus which acquires and displays images of a uterine cervix, and in some cases can automatically diagnose the onset of a disease related to the uterine cervix, the apparatus being characterized by comprising: a main body in which a camera for acquiring uterine cervical images is installed on one side, a user interface for displaying the uterine cervical images and inputting user touch commands is installed on the opposite side, and a handlebar unit is formed in a downward direction; a light source unit which emits light toward the front of the main body; a battery which is positioned inside the handlebar unit to supply power for charging and operation; an operation button unit which includes at least an image capturing button, a zoom-in button, and a zoom-out button formed on the handlebar unit; a memory for storing the captured uterine cervical images; a communication unit for transmitting the uterine cervical images to a reading computer; an image transmission control unit for controlling to store the captured uterine cervical images in the memory, encrypt selected uterine cervical images, and transmit the encrypted images to the reading computer; a display screen control unit which controls to display, on the left and right or above and below the captured uterine cervical display images, a menu bar for receiving the user touch commands; and a camera control unit which controls zooming and auto-focusing of the camera and the brightness of the light source unit according to operations of the provided button.

An optical measurement system is provided, which includes a light source device, a fiber module, an optical detection device and a processing circuit. The light source device is configured to generate light to illuminate a target tissue area and a reference tissue area of a human body. The fiber module is configured to direct and transmit the light to illuminate the target tissue area and the reference tissue area and receive response beams from the target tissue area and the reference tissue area. The optical detection device is configured to detect the response beams from the target tissue area to obtain the target spectrum signal and detect the response beams from the reference tissue area to obtain a reference spectrum signal. The processing circuit configured to calculate a health status parameter of the target tissue area according to the target spectrum signal and reference spectrum signal.

A system for imaging and examination of a cervix, comprising a control module connectable with a changeable head configured to image the cervix and collect a tissue biopsy, the head selected from a group consisting of a digital colposcope module, a transvaginal optical probe module and an endo-cervical endoscope module. The system may additionally comprise light source(s) to illuminate cervix tissue; sensing device(s) to generate signal(s) from light and/or to acquire image(s) of a portion of a cervix; and processor(s) in communication with the sensing device(s). The system is configured to: (i) analyze the signal(s); (ii) detect the size of the cervix; (iii) determine parameters defining properties of the cervix; (iv) determine and distinguish normal tissue from abnormal tissue within the cervix; (v) determine the location of area(s) of abnormal tissue in the cervix; and (vi) generate a panoramic view of the cervix.

The present invention relates to an automatic cervical cancer diagnosis system for performing machine learning by classifying cervical data required for automatic diagnosis of cervical cancer according to accurate criteria and automatically diagnosing cervical cancer based on the machine learning, the automatic cervical cancer diagnosis system including: a learning data generator configured to classify unclassified photographed image data for a cervix transmitted from an external device or a storage according a combination of multi-level classification criteria to generate learning data for each new classification criterion in a learning mode; a photographed image pre-processer configured to pre-process photographed cervix images; a cervical cancer diagnoser including a machine learning model for cervical cancer that learns a characteristic of the learning data generated for each classification criterion in the learning mode, wherein the machine learning model generates diagnosis information about whether cervical cancer has occurred with respect to the pre-processed photographed cervix image; a screen display controller configured to display and output a user interface screen configured to display the diagnosis information and inputting evaluation information according to a reading specialist; a retraining data generator configured to extract information required for retraining from the evaluation information input through the user interface screen and request retraining the machine learning model; and a diagnosis and evaluation information storage configured to store the diagnosis information about whether cervical cancer has occurred and the evaluation information input through the user interface screen.

An apparatus for determining a force F.sub.tip applied to a tip of an electrical impedance spectroscopy probe includes a load cell, accelerometer, and a processing means. The probe tip has a substantially planar distal end for contacting human or animal tissue. The load cell measures the force F.sub.loadcell applied axially along a longitudinal axis when the probe tip is in contact with human or animal tissue. The accelerometer measures a gravity vector A.sub.axial. The apparatus includes a means for compensating for the mass of the probe tip using the measured force and the gravity vector to produce a calibrated measurement force F applied to the probe tip.

A system for providing information for diagnosing preterm birth risk includes: two or more transmit electrodes, contacting cervical tissues, for applying a plurality of first signals at different frequencies to the cervical tissues, two or more detect electrodes, contacting the cervical tissues, for detecting a plurality of second signals generated in response to the first signals, the second signals corresponding to the first signals, and a source configured to generate a plurality of signals. The system obtains a plurality of impedances of the cervical tissues based on the first and the second signals and applies data quality requirements for diagnosing the preterm birth risk. The data quality requirements include checking at least one of signal generation, signal reception, impedance calculation, quality of the first signals, quality of the second signals, and the impedances. The system includes a diagnosis engine configured to receive data including impedances that satisfy the data quality requirements, classify the data into different groups, each representing different status, based on correlation between the data, patient’s information and the preterm birth risk, and output information for diagnosing the preterm birth risk.

Provided herein is a self-contained physiological measuring device adapted for disposition within a patient body cavity, primarily the vagina, for an extended period of time (e.g., 6-48 hours or more). While disposed within the body cavity, the device periodically measures one or more physiological parameters at known locations within the body cavity. In addition to measuring such physiological parameters, the device is operative to store such measurements to memory for subsequent download/processing upon removal of the device from the body cavity and/or upon wireless interrogation.

The present invention comprises methods and devices comprising a cutting element used to contact circumferentially and longitudinally the surface walls of the endocervical canal to provide for broad and complete contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endocervical curettage or screening pap smear. The device may provide for a reservoir for the obtained sample to be contained when removing from the cervical canal and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

The present invention relates to intravaginal devices, systems including the devices, and methods of using the devices to train an individual in the performance of exercises (e.g., pelvic floor lifts (PFLs) and pelvic floor relaxations (PFRs)) that strengthen the individual's pelvic floor muscles in order to treat or prevent pelvic floor disorders (e.g., pelvic organ prolapse and incontinence) and their accompanying symptoms.