Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

An apparatus for radiopharmaceutical quantification of a body part includes a processor configured to receive at least one gamma image of a body part acquired by at least one gamma camera configured to detect gamma and/or X-rays. The at least one gamma image comprises spectral energy data that includes data resulting from decay of at least one radiopharmaceutical. The processor is configured to determine an activity of the at least one radiopharmaceutical at a plurality of spatial positions in the body part and determines a spatial distribution of the at least one radiopharmaceutical in the body part. The determination for a spatial position of the plurality of spatial positions comprises correlating a generated synthetic spectrum to an experimental spectrum generated from the spectral energy data for at least one position in the at least one gamma image that corresponds to that spatial position.

Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

A hand-held probe for measuring radiation or magnetic activity includes a probe having a handle having a longitudinal axis and a shaft portion adapted to be inserted or held above a radiation or magnetic emitting source implanted within a patient's body or tissue of interest, the shaft portion includes a radiation or magnetic activity sensor configured to detect and measure radiation emitted from the radiation emitting source or magnetic activity from a magnetic source; the radiation emitting source being an implanted seed or a radioisotope that is injected near a tumor site in the patient's body; the probe including a signal processing device for further processing the measured radiation or magnetic activity; and a communication medium to exchange data from the hand-held probe with an external data processor unit.

An analysis apparatus according to an embodiment includes an extraction unit, a calculation unit, and an evaluation unit. The extraction unit extracts a detection value in a tumor region, a blood region, and a muscle region from a nuclear medicine image of a subject administered with a drug containing a radiolabeled anticancer drug that works by accumulating in a tumor. The calculation unit calculates a first comparison value that is a comparison result between the detection value in the blood region and the detection value in the tumor region, and a second comparison value that is a comparison result between the detection value in the muscle region and the detection value in the tumor region. The evaluation unit evaluates an accumulation of the drug in the tumor, based on the first comparison value and the second comparison value calculated by the calculation unit.

An imaging capsule including, a radiation source, a collimator that provides a collimated beam from the radiation source, at least one detector configured to detect particles resulting from X-ray fluorescence and/or Compton backscattering in response to the collimated beam to reconstruct images of a user's gastrointestinal tract, wherein the imaging capsule is configured to identify an inflamed area, within the user's gastrointestinal tract, based on a count of the detected particles and initiate actions responsive to detecting the inflamed area.

Various embodiments of a device for in-vivo measurements radiopharmaceuticals used for diagnosis and monitoring of radiotherapy are presented. In some embodiments, the present disclosure relates to a device having a cannula that may include a measurement chamber, a radiation detector and a delivery lumen, wherein the device may be used to both deliver material to the patient (e.g., radiotracers used in radiopharmaceuticals) and measure levels and concentrations of radioactive material in, for example, the patient's blood both during and after administration of the radioactive material. In some embodiments, particles emitted by the radioactive material interact with a scintillation material, resulting in the release of light that may be transmitted, via the scintillation material and/or fiber optic material, to an optical detectors or processor for processing. In some embodiments, particle absorbing materials may be used to limit measurements to materials within the measurement chamber or other area of interest.

The subject matter discloses a multi-sensor endoscope having a dynamic field of view comprising an elongated shaft terminating with a tip section; a maneuvering section connected to the elongated shaft; at least two sensors, wherein at least one sensor is placed behind the tip section, on the maneuvering section; and one or more illuminators located on external surface of the shaft. In some cases, the sensors include a camera. The subject matter also discloses a multi-sensor endoscopy system comprising an endoscope comprising a handle and a controller, such that the maneuvering section is controlled by the controller.

An apparatus for detecting a locating medium in tissue includes a probe, and a console. The probe includes a handle and a detector disposed on a distal end of the probe. The console is in communication and includes a display. The display has a first graphical representation and a second graphical representation. The first graphical representation is configured to depict a count real-time count based on a signal from the detector. The second graphical representation is configured to depict a target count.

A dual-mode microwave applicator for treating tissue comprises a control unit, a rod-shaped element, a coaxial line, and a metal sleeve. The control unit controls the applicator in an application mode and a sensing mode. In the application mode microwave radiation is applied and during the sensing mode tumorous tissue is detected. The rod-shaped element comprises a tip. The coaxial line is formed in the rod-shaped element to relay microwaves to the tip for treatment of the tissue. The coaxial line comprises an inner conductor and an outer conductor. The outer conductor includes a slot of a slot length formed at a slot distance from the tip. The metal sleeve at a sleeve distance from the slot. The sleeve distance is about 0.55 mm, the slot length is about 1.75 mm, and the slot distance is about 7.7 mm.