Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

The present disclosure relates to a method for removing residual acid of implant that has been surface treated using acid, the method including thermal decomposition step of thermally decomposing and removing the acid remaining on the implant; base treatment step of treating the acid remaining on the implant with base, thereby neutralizing and removing the acid; and washing step of washing and removing the acid and the base remaining on the implant with washing water.

According to the present disclosure, the acid remaining on the surface of the fixture can be effectively removed, and thus there is an effect of preventing the problem of bone loss that may occur near the placed implant.

A medical implant includes a first implant body and a pre-coating covering at least a portion of an outer surface of the first implant body. The pre-coating has a negative Poisson's ratio. A method of making a medical implant includes applying a precursor material on a surface of a first implant body, the first implant body having a positive Poisson's ratio. A stimulus is applied to the precursor material, the stimulus causing the precursor material to form a coating having a negative Poisson's ratio

Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

The invention relates to a white, bacteria-resistant, biocompatible, adherent coating for an element which can be integrated in hard and soft tissue, in particular an implant, a screw or a plate, having a structure made from metalliferous gradient layers having varying oxygen content, wherein the band gap of the outer-most gradient layer is greater than 3.1 eV, wherein the outer-most gradient layer is crystalline and wherein the gradient layers comprise tantalum and/or niobium and/or zirconium and/or titanium.

A process for providing a sterilized dental article, at least a portion of the surface of which exhibiting a contact angle of less than 45°. The process includes the subsequent steps of a) providing a dental article and b) subjecting the initial dental article to a hydrogen peroxide plasma treatment. It is characterized in that the hydrogen peroxide plasma sterilization treatment of step b) is carried out in the presence of a carbon-containing compound, which during treatment is converted to form a carboxylic group attached to the surface of the dental article.

The present invention discloses a dental implant configured to be inserted in a hole in jaw bone and to be at least partially situated in the bone tissue when implanted and comprises: a coronal region, an apical region, a longitudinal axis extending from the coronal region of the dental implant to the apical region of the dental implant; an implant surface configured to form an interface between an implant material and the oral environment/surrounding tissue and a surface layer formed on at least part of said implant surface, said surface layer comprising crystalline titanium oxide in the anatase phase and wherein the surface area roughness Sa and the pore size of the implant surface on which said surface layer is formed increase from the coronal region toward the apical region of the dental implant along the longitudinal axis.

Disclosed are compositions, methods and processes for fabricating and using a device or other implement including a surface or surfaces having a nanoscale or microscale layer or coating of Si—O—N—P. These coatings and/or layers may be continuous, on the surface or discontinuous (e.g., patterned, grooved), and may be provided on silica surfaces, metal (e.g., titanium), ceramic, and combination/hybrid materials. Methods of producing an implantable device, such as a load-bearing or non-load-bearing device, such as a bone or other structural implant device (load-bearing), are also presented. Craniofacial, osteogenic and disordered bone regeneration (osteoporosis) uses and applications of devices that include at least one surface that is treated to include a nanoscale or microscale layer or coating of Si—O—N—P are also provided. Methods of using the treated and/or coated devices to enhance enhanced vascularization and healing at a treated surface of a device in vivo, is also presented.

The present disclosure relates to a prosthesis for dental replacement, the prosthesis includes a root. The root includes an abutment and a base portion. The abutment is adapted for affixation of a dental crown thereto. The base portion is shaped for insertion into a tooth socket. The base portion includes a core, a metallic oxide layer on the core and a film-like stem cell layer on the metallic oxide layer. The metallic oxide layer has a number of holes.

A medical implant includes a base portion configured for implantation into a bone of a patient. The base portion is formed from an electrically insulating and biocompatible base material with retaining features on an outer surface of the base portion for gripping the bone in the patient and at least two discontinuous regions formed of titanium on the outer surface.