A device for therapeutic neuromodulation in a nasal region can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

A device for indirect temperature regulation of the brain of a human via a nasal cavity thereof, the device comprising: a membrane having a membrane surface area, a length, a center point with respect to the length, a width, and a center point with respect to the width, said membrane adapted to be arranged in contact with a surface of the nasal cavity, said membrane defining a closed volume and having the shape of the nasal cavity such that when in use, it expands and conforms to the nasal cavity, a first catheter, a second catheter, and means for circulating said fluid into said volume via said first catheter and out of said volume via said second catheter.

A skin treatment apparatus, such as a microdermabrasion or dermaplaning apparatus, includes a housing having a top end and a bottom end, a treatment head attached to the top end of the housing and arranged to exfoliate skin within a treatment area, and a cooling member provided on the bottom end of the housing arranged to cool skin within the treatment area.

A skin treatment apparatus, such as a microdermabrasion or dermaplaning apparatus, includes a housing having a top end and a bottom end, a treatment head attached to the top end of the housing and arranged to exfoliate skin within a treatment area, and a cooling member provided on the bottom end of the housing arranged to cool skin within the treatment area.

An applicator has a stem, one or more tips, and one or more chambers which may hold therapeutic or medicinal fluids. The applicator may be separated into two sections so the tips can be used independently. The fluids held in the chambers may be separated with one or more frangible walls which can be broken to release or mix the fluids. The tips are used as applicators for the therapeutic or medicinal effects produced by the fluids or the medicines contained in the cavity.

Removable liquid heat exchanging element (100) for use in a device for temperature control treatment (400) comprising a support structure (300), and a liquid transporter (200) supported by the support structure (300). The removable liquid heat exchanging element (100) is configured to be positioned in a slot (402) in the device for temperature control treatment (400). The liquid transporter (200) comprises an inlet (201) and an outlet (206) and a lumen for liquid transportation. The lumen is at least partially enclosed by a heat exchanging portion (205) of a flexible wall configured to engage a heat exchanging surface (401a, 401b) of the device for temperature control treatment (400). The support structure (300) is configured to engage and partially enclose a portion of the liquid transporter (200) such that an occlusion (203) is formed between the inlet (201) and the heat exchanging portion (205) of the lumen for liquid transportation.

A device comprising a heat-generating component that comprises an alkali metal is provided. The alkali metal in the presence of water at a point of contact of the device undergoes an exothermic reaction to generate heat in situ. The amount of heat generated is proportional to and/or limited by the amount (or moles) of water at the point of contact, and the heat generated is sufficient to achieve an increase in temperature at the point of contact to achieve a therapeutic or beneficial result. In one embodiment, the device is used for reducing sweat production in a subject suffering from excessive sweating or hyperhidrosis. In other embodiments, the device is used to substantially sterilize a surface or render a surface substantially aseptic.

A first responder device for treating blood flow from a deep wound or a bodily cavity having an inflatable balloon, a first chamber accommodating a liquid arranged for inflating the balloon, a second chamber accommodating a cooling agent capable of dissolving in the liquid when coming in contact therewith, thereby lowering the temperature, a rupturable seal between the first and second chambers, and a structure for forcing the liquid out of the first chamber into the inflatable balloon, and for rupturing the rupturable seal.

In an example, a cryotherapy device includes an elongated shaft, and a cryotherapy delivery member coupled to a distal end of the elongated shaft. The cryotherapy delivery member is configured to apply, from a fixed position in a nasal cavity, thermal energy to at least one of a plurality of nerves in the nasal cavity or a plurality of branches of a nerve in the nasal cavity.