Methods are provided for reducing body fat, volume of fat pads, and/or lipoma(s) in a subject. The methods as provided herein may include injecting a fat-sculpting liquid into a treatment region of the subject, wherein the fat-sculpting liquid has a temperature of −25° C. to 10° C. when injected and is substantially free of frozen particulates. The methods for reducing body fat in a subject may further include injecting a fat-sculpting liquid comprising saline and benzyl alcohol into a treatment region of the subject, wherein the fat-sculpting liquid has a temperature of −15° C. to 5° C. when injected and is substantially free of frozen particulates.

The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling.

The present invention provides methods and devices for controlling a cold slurry that is delivered to a target tissue and for limiting heat transferring from surrounding tissue to the target tissue. In particular, a balloon structure is deployed at or near a point of delivery to act as a physical and/or thermal barrier. In some instances, the balloon structure can act as a pressure device obstructing the flow of warm blood into a treatment area, which can melt the cold slurry.

A system for laparoscopic thermal treatment of visceral fat includes an elongate cooling probe configured for placement through a trocar, the probe including an elongate shaft having a proximal end and a distal end and having a maximum transverse dimension, and an expandable endpiece having a proximal end and a distal end, and including a collapsed state configured for placement through a channel of the trocar and an expanded state, the expanded state having a maximum outer diameter, the maximum outer diameter at least about twice the maximum transverse dimension of the shaft, wherein the proximal end of the endpiece is sealingly coupled to the distal end of the shaft, and a heat exchanger coupled to the cooling probe and configured to remove heat from the endpiece such that adipose tissue placed in contact with the endpiece can be cooled to a temperature of between about 2° C. and about .sup.+1° C.

In methods for treating a patient, a time varying magnetic field is applied to a patient's body and causes a muscle contraction. The time-varying magnetic field may be monophasic, biphasic, polyphasic and/or static. The method may reduce adipose tissue, improve metabolism, blood and/or lymph circulation. The method may use combinations of treatments to enhance the visual appearance of the patient.

Methods and devices for reducing visceral fat within the mesenteric structure of the body by cooling visceral fat within the mesentery while leaving arteries, veins, nerves and lymph nodes within the mesentery, and the mesentery membrane, undamaged, and thereafter allowing natural processes of the body to eliminate the cooled visceral fat from the body. The system comprises a pair of flat-faced cooling probes configured for insertion into the abdomen and placement on opposite sides of a section of mesentery for application of cooling power to the mesentery, at temperatures in a range which kills visceral fat cells but does not harm other tissue.

A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a support having a first portion and a second portion. A first cooling element having a first heat exchanging surface is located at the first portion of the support. A second cooling element having a second heat exchanging surface is located at the second portion of the support. At least one of the first and second cooling elements is movable along the support and is configured to rotate for adjusting an angle between the first and second heat exchanging surfaces.

A system and method of monitoring, controlling and/or detecting events during the removal of heat from subcutaneous lipid-rich tissue is described. In some examples, the system detects an increase in temperature at a treatment device in contact with the skin of a subject, determines that the increase in temperature is related to a treatment event, and performs an action based on the determination. In some examples, the system shuts off the treatment device, alerts an operator, or reduces the cooling in response to a determined treatment event.

Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and/or causing an ischemia-reperfusion injury to, the cooled tissue.

A treatment system for cooling subcutaneous lipid-rich cells in a human subject includes an applicator and a control unit. The treatment system has a cooling mode for cooling tissue and a heating mode for warming tissue. The control unit includes a circulation circuit in fluid communication with the applicator, a chiller apparatus configured to chill fluid from the applicator circulation circuit, and a heater apparatus to warmed fluid from the applicator circulation circuit. The control unit mixes the chilled fluid and/or the warmed with fluid in the applicator circulation circuit control the temperature of the fluid circulated in the applicator.