The present disclosure relates generally to small-gauge instrumentation for surgical procedures, and more specifically, to vitreoretinal instruments for retinal repair and reattachment procedures, as well as associated methods of use. Certain embodiments of the present disclosure provide a curved or articulating probe configured to provide illumination, fluid aspiration, and endophotocoagulation. Accordingly, the probe enables aspiration of subretinal fluid that re-accumulates after initial drainage and during endophotocoagulation without the need to exchange surgical instruments or insert an additional instrument into the intraocular space. Furthermore, the combined functionalities of the probe enable a surgeon to simultaneously perform scleral depression with the surgeon's other hand while aspirating fluid and/or performing retinal endophotocoagulation.

In some examples, a laser-based ophthalmological surgical system (hereinafter “system”) includes a therapeutic radiation source configured to emit therapeutic radiation with a first wavelength. The system may also include a probe radiation source configured to emit probe radiation with a second wavelength different than the first wavelength. The system may also include one or more optical elements configured to direct the therapeutic radiation and the probe radiation into an eye of a patient and to collect reflected probe radiation from the eye of the patient. The reflected probe radiation may be indicative of an amount of therapeutic radiation exposure of the eye of the patient. The system may also include a photodetector configured to receive the reflected probe radiation from the one or more optical elements and to generate a photocurrent indicative of the amount of therapeutic radiation exposure of the eye of the patient.

A reusable laser probe with single-use optic fiber may include a reusable handle, an optic fiber fixture, and a single-use optic fiber. The single-use optic fiber may include an optic fiber having an optic fiber distal end and an optic fiber proximal end. The optic fiber may be disposed in a first transitory connector having a first transitory connector distal end and a first transitory connector proximal end wherein the optic fiber distal end extends a fixed distance from the transitory connector distal end. The optic fiber may be disposed in a second transitory connector having a second transitory connector distal end and a second transitory connector proximal end wherein the optic fiber proximal end extends a fixed distance from the second transitory connector distal end. The first transitory connector may be inserted in the reusable handle and the second transitory connector may be inserted in the optic fiber fixture.

A microsurgical instrument having one or more distance indication members is provided. In a particular embodiment, the microsurgical instrument comprises a microsurgical tool and a first distance indication member coupled to, and extending beyond a distal end of, the microsurgical tool. A distal portion of the first distance indication member may be configured to deflect when in contact with a tissue surface, without causing damage to the tissue surface, to give a visual indication that the distal end of the microsurgical tool is in proximity to the tissue surface. The distal portion of the distance indication member can be further configured to return to a non-deflected configuration when no longer in contact with the tissue surface.

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

Near-infrared/Mid-infrared lasers are used to de-claudicate glaucomatous tissue, translocate extra-ocular muscles, thermally pulsate palpebrae, and penileate/vasodilate superficial/epi-scleral membranes for dmg delivery. Diffractive optic element-mediated laser patterns may irradiate eye tissues under pulsed or continuous wave regimes with programmable durations and sequences for efficient treatments while minimizing adverse effects.

The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.

A probe tip assembly includes an optical fiber for channeling light energy and a straightening tube circumscribing at least a portion of the optical fiber. The straightening tube is moveable between a first position and a second position. The tip assembly also includes a guiding member circumscribing the optical fiber and the straightening tube. The guiding member includes a curvable portion configurable between a pre-formed curved state and a straightened state, wherein, as the straightening tube is retracted from the first position to the second position, the guiding member transitions from its straightened state to its pre-formed curved state. An external surface of the straightening tube contacts an internal surface of the guiding member when the straightening tube is in the first position and the guiding member is in the straightened state.

A method and system perform an ophthalmic procedure on an eye having an optical path from the lens to the retina. An image of at least part of the eye is received in a data processing unit. The image includes the optical path. The data processing unit determines keep out zone(s) and identifies undesirable feature(s) based on the image. The keep out zone(s) include the retina. The data processing unit also selects one of the undesirable feature(s) for removal. At least part of the undesirable feature is outside of the keep out zone(s). Confirmation for removal of the undesirable feature is received in the data processing unit. In response to receiving the confirmation, a control unit controls a laser to perform laser removal the at least the portion of the undesirable feature without targeting any portion of the keep out zone(s).

In some examples, a laser-based ophthalmological surgical system (hereinafter “system”) includes a therapeutic radiation source configured to emit therapeutic radiation at a first intensity during a therapeutic portion and to emit probe radiation with a second intensity which is less than the first intensity during a probe portion. The system may also include one or more optical elements configured to direct the therapeutic portion and the probe portion into an eye of a patient and to collect reflected radiation from the eye of the patient. The reflected radiation may be indicative of dynamics of microbubbles in the cells of the eye of the patient.