A method of corneal implantation with cross-linking is disclosed herein. In one or more embodiments, the method includes the steps of: (i) prior to implantation, treating an implant formed from donor corneal tissue or a tissue culture grown corneal stroma with a solution of sodium dodecyl sulfate (SDS), Triton X-100, benzalkonium chloride (BAK), Igepal, genipin, 100% glycerol, or alcohol for making the implant acellular, and for killing any bacteria, viruses, or parasites prior to implantation; (ii) implanting the implant into a recipient cornea; (iii) applying laser energy to the implant so as to modify the refractive power of the implant while being monitored using a Shack-Hartmann wavefront system so as to achieve a desired refractive power for the implant; and (iv) applying a cross-linking solution and irradiating the implant to cross-link the implant to prevent an immune response to the implant and/or rejection of the implant by a patient.

An example method for cutting a plurality of lenticules from a donor cornea includes receiving a donor cornea, cutting a first layer of a first set of lenticules from the donor cornea, and cutting a second layer of a second set of lenticules from the donor cornea. The lenticules are cut according to a pattern that to maximizes the number of lenticules, thereby maximizing the number of implants from the single donor cornea. An example implant handling device includes a body. The body includes a flattened end configured to receive a corneal implant and keep the corneal implant from rolling or folding. The flattened end has a width and a height, the width being greater than the height. The body includes a slit opening to the flattened end, the slit opening configured to allow the corneal implant to pass into the flattened end.

Equipment and methods for refractive surgery, including for keratoplasty. The invention describes equipment and methods for the production and implantation of a lamella of a tissue or material for the purpose of correcting a corneal geometry at maximum precision that is thus improved in relation to the prior art. The invention facilitates restoration of normal corneal geometry together with optical functionality of the cornea which is improved in relation to the prior art. A planning device, a treatment system and a planning method are designed to couple a device coordinate systems of the laser devices involved and characterization devices by application of registration and to uniquely register the supplied measurement data for generating the lamella to be implanted to the device coordinate systems by a specific, defined edge geometry of a blank from which the lamella is produced, and by the lamella, and by additional system and method aids.

A storage/delivery device includes a first wall defining a well configured to receive a corneal tissue. The storage/delivery device includes a second wall configured to be positioned over the first wall and to seal the well. The second wall includes a recess configured to extend into the well to define a chamber between the first wall and the second wall. The chamber is configured to hold the corneal tissue when the second wall seals the well. A system may include the storage/delivery device above and a measurement system configured to measure the corneal tissue disposed in the well. In one example embodiment, the measurement system is an optical coherence tomography (OCT) system. In another example embodiment, the measurement system is a second-harmonic generation (SHG) or third-harmonic generation (THG) microscopy system.

A method of lamellar corneal graft implantation is disclosed herein. In one or more embodiments, the method includes the steps of: (i) modifying a genetic component of a lamellar cornea or other tissue of an animal so that the lamellar cornea or other tissue of the animal can be used for human transplantation; (ii) decellularizing the lamellar cornea or other tissue ex vivo using chemical means; (iii) modifying a shape of the lamellar cornea or other tissue before or after transplantation; and (iv) applying a photosensitizer and ultraviolet radiation to the lamellar cornea or other tissue so as to crosslink collagen and intercellular proteins of the lamellar cornea or other tissue, kill the cells exposed to the photosensitizer, and eliminate an immune response by a host to the implanted lamellar cornea or the tissue.

An ablatable corneal inlay for correction of refractive errors and/or presbyopia, and a method of correcting refractive errors and presbyopia in an eye of a patient using an ablatable corneal inlay is disclosed herein.

System and method of photoaltering a region of an eye using a high resolution digital image of the eye. The system includes a laser assembly for outputting a pulsed laser beam, an imaging system for capturing a real-time high resolution digital image of the eye and displaying the digital image of the eye, a user interface receiving at least one laser parameter input, and a controller coupled to the laser assembly, imaging system, and user interface. The controller directs the laser assembly to output the pulsed laser beam to the region of the eye based on the laser parameter input.

The disclosure relates to an ophthalmic surgery apparatus for making an incision in ocular biological tissue such as a cornea or a crystalline lens. The apparatus includes: a laser source suitable for delivering a beam of laser pulses; an optical focusing system for focusing the beam of laser pulses on a focal point in the ocular biological tissue; an optical system for moving the beam of laser pulses, configured to move the focal point along a predetermined three-dimensional trajectory; a control unit configured to control the laser source, and the optical system for moving the beam of laser pulses, in such a way that the parameters of the beam of laser pulses and the parameters of the optical system for moving the beam of laser pulses are adjusted according to the position of the focal point in the trajectory during the incision.

Exemplary arrangements relate to a method for producing an implant, in particular an implant configured to be inserted into a Schlemm's canal of an eye, which includes the steps of providing an implant blank, which implant blank is comprised of material that is permeable to laser radiation. The method further includes subjecting at least one region of the implant blank to laser radiation. Subsequent to subjecting the least one region to radiation, the method further includes removing material from the at least one region via fluid etching.

An ophthalmological treatment apparatus for resecting a patient cornea element form a patient cornea in posterior lamellar keratoplasty, an ophthalmological manufacture apparatus for manufacturing from a donor cornea a cornea implant, as well as corresponding manufacture and implantation methods are disclosed. The patient cornea cut pattern that is implemented in the patient cornea defines a patient cornea interlocking structure, the patient cornea interlocking structure being configured to interlock the patient cornea with a cornea implant after replacing the patient cornea element by the cornea implant. The corneal implant may have a corresponding cornea implant interlocking structure. The patient cornea interlocking structure and the cornea implant interlocking structure may be arranged at the posterior side of the patient cornea element and the cornea implant, respectively. The ophthalmological treatment apparatus and the ophthalmological manufacture apparatus may include in each case an ophthalmological laser device, in particular with a femtosecond laser source.