A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

The present invention generally relates to the use of pre-formed bodies of Chemically Bonded Ceramics (CBCs) biomaterial for implantation purposes wherein the bodies are prepared ex vivo allowing process parameters to be optimized for desired long term properties of the resulting CBC biomaterial. More particularly, the pre-formed CBC material bodies of the present invention are sintered. The pre-formed body of CBC material is machined to the desired geometry and then implanted using a CBC cementation paste for fixation of the body to tissue. The invention also relates to a method of preparing pre-formed bodies of CBC biomaterial for implantation purposes, methods of preparing an implant thereof having desired geometry, and a method of implantation of the implant, as well as a kit for use in the method of implantation.

The present invention relates to a dental composition including cement and a non-aqueous liquid, wherein the cement includes a first domain including alite, a second domain including belite, and a matrix located between one or more selected from the group consisting of the first domain and the second domain and configured to include silicon (Si)-atom-doped tricalcium aluminate (3CaO.Al.sub.2O.sub.3). A dental hydraulic composition according to the present invention is a single ointment-type composition, and is thus easy to use and exhibits a good aesthetic appearance, high curability and high biocompatibility.

The present invention relates to a dental composition including cement and a non-aqueous liquid, wherein the cement includes a first domain including alite, a second domain including belite, and a matrix located between one or more selected from the group consisting of the first domain and the second domain and configured to include silicon (Si)-atom-doped tricalcium aluminate (3CaO.Al.sub.2O.sub.3). A dental hydraulic composition according to the present invention is a single ointment-type composition, and is thus easy to use and exhibits a good aesthetic appearance, high curability and high biocompatibility.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

The present disclosure provides a root-canal sealer composition including cement and a hygroscopic liquid, in which the cement includes tricalcium silicate (3CaO.SiO.sub.2) in which an aluminum atom (Al) is solid-soluted (Al solid-soluted C3S), dicalcium silicate (2CaO.SiO.sub.2) in which an aluminum atom (Al) is solid-soluted (Al solid-soluted C2S), and tricalcium aluminate (3CaO.Al.sub.2O.sub.3) in which a silicon atom (Si) is solid-soluted (Si solid-soluted C3A), the tricalcium aluminate being disposed between at least one selected from the group consisting of the Al solid-soluted C3S and the Al solid-soluted C2S. When the cement including aluminum solid-soluted tricalcium silicate, aluminum solid-soluted dicalcium silicate, and silicon solid-soluted tricalcium aluminate is prepared and used for a root-canal sealer composition, a curing time is reduced and compressive strength is increased. Also, the root-canal sealer composition is effective at ensuring a sufficient working time, thereby improving workability and storage stability.

The present disclosure provides a root-canal sealer composition including cement and a hygroscopic liquid, in which the cement includes tricalcium silicate (3CaO.SiO.sub.2) in which an aluminum atom (Al) is solid-soluted (Al solid-soluted C3S), dicalcium silicate (2CaO.SiO.sub.2) in which an aluminum atom (Al) is solid-soluted (Al solid-soluted C2S), and tricalcium aluminate (3CaO.Al.sub.2O.sub.3) in which a silicon atom (Si) is solid-soluted (Si solid-soluted C3A), the tricalcium aluminate being disposed between at least one selected from the group consisting of the Al solid-soluted C3S and the Al solid-soluted C2S. When the cement including aluminum solid-soluted tricalcium silicate, aluminum solid-soluted dicalcium silicate, and silicon solid-soluted tricalcium aluminate is prepared and used for a root-canal sealer composition, a curing time is reduced and compressive strength is increased. Also, the root-canal sealer composition is effective at ensuring a sufficient working time, thereby improving workability and storage stability.

Provided is a curable composition that has a sufficient pot life and does not cause a significant delay in curing time even after long-term storage at room temperature or higher. A separately packed curable composition includes: (A) a first pack containing: (a1) a polymerizable monomer having no acidic group, (b) a polymerizable monomer having an acidic group, and (c) a transition metal compound; and (B) a second pack containing: (a2) a polymerizable monomer having no acidic group, (d) an aromatic amine compound, and (e) at least one compound selected from sulfinic acid and a salt thereof.