A method of providing an anti-microbial coating on an object, comprises the steps of pretreating the object in a first oxygen plasma to graft oxygen-based functional groups on the surface of the object by plasma enhanced chemical vapour deposition, coating the pretreated object with a suspension of particulate graphene oxide to provide a graphene oxide coating on the object, treating the object in a hydrocarbon plasma to deposit an amorphous hydrocarbon film on the graphene oxide coating by plasma enhanced chemical vapour deposition, and treating the object in a second oxygen plasma configured to etch and flatten the coatings on the surface of the object. A prosthetic implant having a metal or metal alloy surface and an anti-microbial coating on all or part of the surface is also described.

The present invention generally relates to the use of small particles, such as micro particles or nanoparticles, to produce a therapeutic scar such as “trans-mural” scarring or other desired “deep tissue” scarring. In one preferred embodiment, these particles can be delivered to a target location by an implant. More specifically, these particles can be incorporated into the structure of implants or into the coatings on implants. In another preferred embodiment, these small particles can be delivered directly with a catheter by electrophoresis or hydraulic pressure.

An implant comprises a substrate and a coating on a surface of the substrate, and the coating comprises silicon nitride and has a thickness of from about 1 to about 15 micrometer. A method of providing the implant comprises coating a surface of the implant substrate with the coating comprising silicon nitride and having a thickness of from about 1 to about 15 micrometer by physical vapour deposition.

A method for coating a medical implant applies at least one coating to at least one surface of the implant by plasma polymerization. The implant has pores sized in the nanometer range. The method stabilizes the pores. The plasma polymerization is conducted in the presence of a coating gas and oxygen. A coating parameter can be selected so that a rough surface of the implant is coated. An implant includes a membrane having pores sized in the nanometer range. A surface of the implant is at least partially coated with a plasma polymer. The interior of the pores is uncoated.

This invention is directed to composites and films comprising hydroxyapatite, biodegradable polymer, a biocompatible surfactant with inorganic fullerene-like (IF) nanoparticles or inorganic nanotubes (INT); methods of preparation and uses thereof.

An orthotopic artificial bladder endoprosthesis includes a casing made of a PGA fiber fabric; the casing having two first connectors for the connection with the ureters of a patient and a further connector for the connection with the urethra of a patient; an inflatable element inserted in the casing; the inflatable element being switchable between an inflated configuration, in which it supports and maintains in position the casing, and a deflated configuration.

Described is a composite material composed of an atomically thin (single layer) amorphous carbon disposed on top of a substrate (metal, glass, oxides) and methods of growing and differentiating stem cells.

A new insight on the lubrication of artificial joint components is presented. Addition of small amounts of nanoscale diamond particles to an artificial joint promotes a substantial improvement in friction and wear behavior of the artificial joint surfaces. Artificial joint implants are made from a variety of materials ranging from metal alloys to polymers. Suitable methods of applying nanoscale diamond particles to an artificial joint include (i) coating an effective amount of nanoscale diamond particles onto the artificial joint prior to implants; (ii) applying a composition to the artificial joint during an artificial joint implanting surgery, wherein said composition comprises a biocompatible carrier fluid and an effective amount of nanoscale diamond particles dispersed in the biocompatible carrier fluid; (iii) injecting the composition for lubricating the artificial joint into the artificial joint.

There is disclosed a method of improving the reliability of coating an implantable medical device, such as a stent, with bioactive material in the absence of a carrier material such as a matrix or polymer layer. The method involves cleaning volatile components from the exposed surfaces of the medical device, removing carbon deposits and then applying a uniform carbon layer in a controlled environment. The deliberately applied carbon layer masks impurities of the underlying native oxide layer and leads to more uniform bioactive material coating not only a over the surfaces of a single medical device but also from device to device within a batch and between batches of devices. This improves production as well as optimising the amount and release of drug on the medical device without the need for a carrier material.

Disclosed are a material with supercapacitance modified surface and a preparation method and application thereof. Specifically, the present disclosure introduces a material having a controllably supercapacitive surface. The surface is chargeable, the full-charged modified surface can interact with bacteria disturbing the electron transfer of respiratory chain of bacteria and inhibiting the growth and reproduction of bacteria in a short-term. The antibacterial rate can be improved by cyclically charging-discharging without losing capacitance, and prevent formation of biofilm of bacteria. The antibacterial system can quantitatively control the antibacterial process without affecting the biocompatibility of the material, and has the advantages of environmental protection and controllability.