This disclosure includes negative pressure wound therapy dressings with local oxygen generation for topical wound therapy. The dressings (18) for facilitating delivery of oxygen and application of negative pressure to target tissue include a manifold (46) that defines a plurality of gas passageways (50) and is configured to allow communication of oxygen to the target tissue; an oxygen-generating material (146) that is configured to release oxygen when exposed to water; a gas-occlusive layer (74) configured to be disposed over the manifold and the oxygen-generating material and coupled to tissue surrounding the target tissue such that an interior volume containing the manifold and the oxygen-generating material is defined between the gas-occlusive layer and the target tissue; and a port (94) coupled to the gas-occlusive layer and configured to be coupled to a negative pressure source.

The wound dressing apparatus facilitates administration of combined negative pressure and positive pressure treatment at a wound site. The wound dressing apparatus includes a wound dome having a substantially hollow dome interior, a manifold that is in fluid communication with the dome interior, a first passage adapted to connect to a negative pressure source to the dome interior, and a second passage adapted to connect to a positive pressure source to the manifold.

A treatment system for debriding a treatment area of a tissue site and applying negative pressure is disclosed. In some embodiments, the treatment system may include an ultrasonic bubble generator fluidly coupled to a negative-pressure source, fluid source, and a dressing. Fluid may be drawn from the fluid source to the ultrasonic bubble generator, whereby micro-bubbles and ultrasonic waves may be generated in the fluid before the fluid is instilled to the dressing.

The wound therapy apparatus may include a wound interface sealingly securable to the skin surface around a wound bed to encloses the wound bed within an enclosed space that is fluid-tight. The wound interface may be sufficiently deformation resistant to distend at least a portion of the wound bed into the enclosed space when pressure p.sub.0 within the enclosed space is less than ambient pressure p.sub.amb. Fluid may be communicated with the enclosed space when the wound interface is sealingly secured to the skin surface in order to vary a pressure p.sub.0 within the enclosed space periodically over the pressure range p.sub.min≤p.sub.0≤p.sub.max. The variation of the pressure p.sub.0 may distend the wound bed into communication with a pad received within the enclosed space and decreases the wound bed contact with the pad. Related methods of use of the wound therapy apparatus are also disclosed.

A system for negative pressure and hypoxic tissue therapy including a chemical pump assembly, a dressing to cover a tissue site, a plurality of hoses, and a cover layer to cover a portion of the dressing. Each hose is configured to fluidly connect the dressing to the assembly. Oxygen flows from the dressing to a reactor in the assembly where the oxygen is consumed by the reactor. The hoses have different cross-sectional areas and selectable lengths, and these can be selected to provide a desired amount of oxygen around the tissue site. The cover layer has less permeability to air that does the dressing, nd can be used to cover a portion of the dressing to inhibit the permeation of air through the dressing and thus provide the desired amount of oxygen around the tissue site.

Systems, methods, and apparatuses for irrigating a tissue site are described. The system can include a tissue interface and a sealing member configured to be placed over the tissue site to form a sealed space, and a negative-pressure source fluidly coupled to the sealed space. The system includes an irrigation valve having a housing, a piston disposed in the housing, a fluid inlet to fluidly couple a fluid inlet chamber to a fluid source, and a fluid outlet to fluidly couple a fluid outlet chamber to the sealed space. A piston passage extends through the piston and fluidly couples the fluid inlet chamber and the fluid outlet chamber, and a biasing member is coupled to the piston to bias the irrigation valve to a closed position. The negative-pressure source is configured to move the piston between the closed position and an open position to draw fluid to the sealed space.

An apparatus for treating a tissue site includes a dressing, an oxygen source, a valve, and a negative-pressure source. The dressing is configured to be sealed around the tissue site. The oxygen source is fluidly coupled to the dressing and configured to provide a low flow of oxygen. A first port of the valve is fluidly coupled to the dressing and the valve moves between a closed position preventing flow through the valve and an open position permitting flow through the valve. The negative-pressure source is fluidly coupled to a second port of the valve and provides negative pressure to the second port of the valve at a non-therapeutic level. The valve separates the negative-pressure source from the dressing and selectively opens when a positive pressure is applied on an upstream side of the valve.

This disclosure includes wound dressings and systems with high-flow therapeutic gas sources for topical wound therapy and related methods. Some dressings, which are configured to be coupled to tissue to facilitate delivery of therapeutic gas to the tissue, comprise a manifold that defines a plurality of gas passageways, the manifold configured to allow communication of therapeutic gas to the tissue; and a gas-occlusive layer configured to be disposed over the manifold and coupled to the tissue such that an interior volume containing the manifold is defined between the gas-occlusive layer and the tissue and the gas-occlusive layer limits escape of therapeutic gas from the interior volume; wherein the gas-occlusive layer includes: a first opening configured to allow communication of therapeutic gas into the interior volume; and one or more second openings configured to allow communication of therapeutic gas out of the interior volume.

This disclosure describes devices, systems, and methods related to oxygenated hemoglobin, the generation thereof, and the use thereof. An exemplary oxygenated hemoglobin therapy system includes an oxygen source configured to provide oxygen and a hemoglobin source configured to provide topical hemoglobin. The therapy system may also include a mixer which has a first inlet, a second inlet, and an outlet. The mixer is configured to mix the oxygen and the topical hemoglobin to form a mixture and to provide the mixture to a dressing via the outlet. The therapy system may further include the dressing. The oxygenated hemoglobin therapy systems described herein are suitable for use in medical devices, such as bandages, drapes, dressings, and wound closures.

A bridge for facilitating delivery of reduced pressure to a wound site includes a reduced pressure lumen configured to be fluidly coupled to a reduced pressure source, a secondary pressure lumen configured to be fluidly coupled to a secondary pressure source, and one or more fluid adapters operable to be connected to a wound dressing disposed at the wound site. The one or more fluid adapters are positioned and configured with respect to the reduced pressure lumen to apply reduced pressure from the reduced pressure lumen to the wound site through the wound dressing and deliver exudate removed from the wound site through the reduced pressure lumen to the reduced pressure tubing. The secondary pressure lumen is fluidly coupled to the reduced pressure lumen to facilitate flow of the exudate removed from the wound site by the reduced pressure source using the secondary pressure source.