Summary

The invention relates to powdered pharmaceutical formulations which, in addition to carrier particles and particulate active ingredient which preferably adheres to the surface of the carrier particles, contains a mixing element, wherein the formulation fluidized in the carrier gas stream can contain the mixing element. Preferably, the powdered pharmaceutical formulation is packaged as a single dose, for example filled into a container as a single dose, for example in a capsule. The mixing element has a size of at least 1 mm to 10 mm in a first dimension and a size of at least 50% of the size it has in the first dimension in the other two dimensions.

An aerosol generating device includes a housing having an open end and forms a cavity in communication with the open end for receiving an aerosol generating article. The device further includes a rotatable capture element disposed in the cavity. The rotatable capture element is operable to retain the aerosol generating article within the cavity. The rotatable capture element is longitudinally movable within the cavity. The device further includes a heating element in communication with the cavity. The heating element is operable to heat the aerosol generating article retained by the capture element within the cavity. Combined rotation and longitudinal movement of the capture element causes the aerosol generating element to spiral relative to the heating element.

Phyto material tablets, tablet vaporizers, methods and apparatus for forming phyto material tablets. The tablets are formed to increase vaporization efficiency. Tablets can include break regions to facilitate fracturing into multiple pieces for vaporization. The tablets can also include multiple layers of different phyto material mixtures. Compression molds are used to shape the tablets. The compression molds can be provided on a rotational assembly to facilitate rapid manufacturing of multiple tablets. The vaporizers include heating chambers that are configured to increase the surface area of the tablets exposed for vaporization. The heating chambers include compression or fracture members that compress and/or encourage fracturing of the tablets to assist vaporization.

Phyto material tablets, tablet vaporizers, methods and apparatus for forming phyto material tablets. The tablets are formed to increase vaporization efficiency. Tablets can include break regions to facilitate fracturing into multiple pieces for vaporization. The tablets can also include multiple layers of different phyto material mixtures. Compression molds are used to shape the tablets. The compression molds can be provided on a rotational assembly to facilitate rapid manufacturing of multiple tablets. The vaporizers include heating chambers that are configured to increase the surface area of the tablets exposed for vaporization. The heating chambers include compression or fracture members that compress and/or encourage fracturing of the tablets to assist vaporization.

Devices and methods are described for preparing, managing, and/or administering metered doses of substances for vaporized administration. In some embodiments, dose cartridges comprising at least one botanical substance include a heating element integrated into the cartridge in close contact with the botanical substance. In some embodiments, cartridge-mounted doses are stored in a magazine, optionally in carousel form, before use. Transport of a cartridge from a magazine to an electrically operated vaporizing chamber which activates the heating element is provided by a mechanical pickup means.

Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

A method of purifying herbal extract(s) from an herbaceous plant composition includes heating the herbal extracts-containing composition to volatilize at least one of herbal extract(s) into a vapor and condensing the vapor on a substrate or wet extracting the herbal extract(s) by treatment of the herbaceous plant composition or a derivative thereof with a solvent for the herbal extract(s), separating the solution of herbal extract(s), forming a concentrate and casting the concentrate on the substrate to form a coating of the herbal extract(s) on the substrate. A corresponding delivery cartridge and delivery system can include a controllable heating element and the substrate coated with at least one of herbal extract(s). These are configured to allow passage of air over the substrate to volatilize or entrain the herbal extract(s) as a vapor, gas or aerosol for administration to a user.

A dose unit including at least one isolated bioactive agent applied on a carrier material in thermal contact with an electrically heating element configured to vaporize a pre-determined amount of the agent for pulmonary delivery thereof is provided herein, as well as devices for effecting vaporization and pulmonary delivery of the isolated agent, and methods for preparing the dose unit, controllably releasing the agent therefrom, methods for pulmonary delivery thereof and methods of treatment of medical conditions treatable by pulmonary delivery of the isolated bioactive agent.

A dry powder inhaler for pulmonary or nasal use, comprising at least an inhaler body (201) and a cartridge (203) with a plurality of powder compartments (205) each including one dose of a drug. The body (201) has an opening (204) shaped for receiving the cartridge (203) and the plastic body recess (215) and the detent (218) to allow a controlled advancement and turning movement of the cartridge (203) relative to the body (201) for sequentially delivering each of the plurality of unit doses filled into the cartridge compartments (205). The inhaler construction is suitable for filling the plurality of unit doses into the compartments (205) with the cartridge (203) assembled into the body (201). The invention affords a large dose inhaler of single-use and low cost that improves industrial filling and manufacturing cost for the delivery of high dosages of inhaled medicines.

A nebulizer for nebulizing a fluid and a reservoir with a fluid are proposed. The reservoir includes a collapsible bag with the fluid, where the bag extends in a circumferential direction within the housing part and wherein the reservoir is manually rotated for tensioning the nebulizer.