A vaporization device includes a first portion and a second portion. The first portion includes a first body defining a first interior volume, a first half of a split-pod, a second half of a split-pod, an opening, a first heating apparatus, and a second heating apparatus. The first half of the split-pod is configured to hold a nicotine-containing liquid. The second half of the split-pod is configured to hold a non-nicotine-containing liquid. The opening separates the first half from the second half of the split-pod. The first heating apparatus is dedicated to the first half. The second heating apparatus is dedicated to the second half. The second portion includes a second body defining a second interior volume and a computing system. The computing system is disposed within the second interior volume. The computing system is configured to vary an amount of current supplied to the first and second heating apparatuses.

A system may include an external device and an inhaler. The external device may include a processor, a communication circuit, and memory. The inhaler may include a mouthpiece, medicament, a mechanical dose counter, and an electronics module comprising a processor and a communication circuit. The electronics module may record a dosing event when the inhaler is actuated, such as when the mouthpiece cover is opened, and send a signal indicating the dosing event to the external device. The external device may receive a mechanical dose reading of the mechanical dose counter, determine an electronic dose reading based on the signal indicating the dosing event, determine that a discrepancy between the mechanical dose reading and the electronic dose reading exceeds a threshold, and notify the user of the discrepancy, for example, by providing a notification to the user by way of a mobile application residing on the external device.

An acoustic dose meter is provided comprising a housing, and a cylindrical seat for staging a pressurized medicine canister. The housing includes at least one compartment for housing electronics and passageways for connecting electronics for power and data communication. A microprocessor including a transient memory containing machine instruction is also included. Additionally, a power source connected to the microprocessor, a power switch connected to the microprocessor and the power source for booting the microprocessor are added. At least one visual display device connected to the microprocessor for displaying available doses is provided. A first set of acoustic sensors connected to the microprocessor and adapted as acoustic sound generators and a second set of acoustic sensors connected to the microprocessor and adapted as acoustic soundwave recorders are implemented to detect and analyze frequencies enabling determining of dosing count availability.

Methods and systems for monitoring the status and usage of a metered dose inhaler (MDI) and communicating status, usage, and guidance information to a user of the MDI and to a mobile computing device are presented herein. An IMD includes a dosage dispense detection device, an accelerometer, and a visual transducer, an audio transducer, a haptic transducer, or any combination thereof. The dosage dispense detection device detects when a user applies a compressive force across the IMD. The accelerometer measures a shaking of the IMD by a user before self-administering a dose. The IMD determines whether the medicine is adequately shaken by the user, and if so, communicates an indication to the user that the pressurized canister of medicine is ready for dosage. In another aspect, the IMD communicates a sequence of indications that mark each transition of a dosage regimen plan to self-administer a dosage of medicine.

Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The inhaler device can be used in a wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system concurrently as the inhalation is performed and thus the subject's inhalation can be evaluated as well as the performance of the inhalation system. The system can also detect the identity of the medicament, its dosage, lot, expiration, etc. and the characteristics profile of a dry powder formulation emitted from the inhalation system in use.

An electronic module for an inhaler includes a printed circuit board and electronic components configured to detect at least a status and/or at least a working parameter of the inhaler when the electronic module is attached to the inhaler. A battery is permanently joined to the printed circuit board. A first terminal and a second terminal are electrically connectable one to the other through a main switch to close a circuit between the battery and the electronic components. In a rest configuration, the first and second terminals are electrically separated by the main switch. In a work configuration, the first terminal and the second terminal are electrically connected one to the other through the main switch.

A respiratory system and method comprise a tracker module adaptable to be secured to a variety of inhalers, the tracker module sensing activation of the medication canister of the inhaler for delivery of medication to a user. The tracker module also senses the rate of inhalation air flow of the user when inhaling medication for determination of proper inhaler use. Upstream and downstream sensors provide flow information to determine quality of the inhalation. Other sensors are provided that monitor user presence at the inhaler, user technique in using the inhaler, and the attitude of the inhaler when it was used. Low power devices are used to conserve battery power.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

A sensing module for monitoring dosage delivery of a vaporized material, and a portable vaporization unit including the sensing module, include a light sensor that detects disruptions in a light path across a vapor channel, the disruptions caused by the vaporized material flowing through the vapor channel. The light sensor includes a UV light source, which may emit 370 nm wavelength light, and a UV light detector that converts intensity of incident light in the light path into a signal. A microprocessor of the sensing module compares the signal to a baseline measurement to determine the concentration of a medicament in the vapor; then, using the flow rate and activation time of the device, the microprocessor determines the dosage and can perform monitoring and reporting actions based on the dosage. A measuring circuit measures fluctuations in resistance/impedance of a vaporization element to further determine flow rate and/or dosage.

Nonpathogenic microorganism preparations for delivery to the intranasal system, kits including nonpathogenic microorganism preparations for delivery to the intranasal system, and devices for administering nonpathogenic microorganism preparations to the intranasal system are provided. Vehicles for intranasal delivery of nonpathogenic microorganisms are provided. Ammonia oxidizing microorganism preparations for delivery to the intranasal system, kits including ammonia oxidizing preparations for delivery to the intranasal system, and devices for administering ammonia oxidizing preparations to the intranasal system are provided. Vehicles for intranasal delivery of ammonia oxidizing microorganisms are provided.