An apparatus and method for providing a nebula or aerosol to a patient is described. In one aspect, the nebulizer is composed of a minimum number of parts to reduce complexity for automated or human assembly. The nebulizer may include an inhalation valve, exhalation valve and biasing member integrated into a single diaphragm structure that may be connected with an actuator and inserted into a housing for controlling nebulization of a medicine to a patient in response to the patient's breathing or in a continuous nebulization mode.

An inhaler (60) has a breath actuated trigger mechanism (100) reactive to an inhalation flow to trigger the release of a substance to be inhaled. The inhaler (60) has an inspiration flow which is subject to a higher degree of flow governing post-triggering than pre-triggering. This allows the triggering flow rate to be closer to, or even higher than, the governing flow rate of the inhaler.

A refill for an inhaler, the refill including a cylinder with an axis and containing a pressurised inhalable composition. An outlet valve at one end has a hollow valve stem extending axially from the cylinder. A cap is fitted onto the cylinder at the outlet end and extends axially beyond the valve stem. The cap has an internal passage extending through the cap to allow access to the valve stem. The internal passage provides a guide wall to guide the inhaler onto the stem during the refill process.

A device for delivering a predetermined amount of at least one substance to a body orifice of a subject includes a) a container for containing said at least one substance; b) a delivery end for placement in proximity to the orifice, the delivery end being in fluid communication with the container; c) a valve mechanically connectable to said container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which said valve enables delivery of predetermined amount of said substance from said container to said body orifice via said delivery end; and, (ii) an INACTIVE CONFIGURATION, in which said valve prevents delivery of said predetermined amount of said substance from said container to said body orifice; d) a trigger mechanism adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION, and vice versa; and e) a fluid tight chamber.

A dispenser for dispensing one or more dry-powder inhaler devices, having at least one compartment configured to hold at least one dry-powder inhaler device, the at least one dry-powder inhaler device comprising a casing enclosing at least one compartment containing an inhalable medicament covered by a cover, and at least one puncture mechanism comprising at least one pin structure operably aligned with the at least one compartment, and at least one obstruction internally located within the dispenser and adjacent to an opening, wherein, upon a dry-powder inhaler device being pulled from a dispenser, the at least one obstruction is configured to actuate the at least one puncture mechanism to extend the at least one pin structure into the casing, thereby puncturing the cover of the at least one compartment.

A device is provided for delivering a predetermined volume of at least one substance within a body cavity of a subject. The device contains a) a capsule for containing the predetermined volume of substances; b) a delivery end, having at least one orifice of diameter D, for placement in proximity to the body cavity; c) a valve mechanically connectable to the capsule, having at least two configurations: (i) an active configuration in which the valve enables delivery of the substances; and (ii) an inactive configuration, in which the valve prevents delivery of the substances from the capsule to the body cavity; and d) a fluid tight chamber configured to contain predetermined volume V.sub.gas of pressurized gas at a predetermined pressure, P.sub.gas. The capsule further contains at least one mixing mechanism that mixes the substances and the pressurized gas after the valve is reconfigured to the active configuration.

The present invention relates to the technical field of an automatic detection trigger device, and discloses an automatic detection trigger device for a quantitative compressed administration aerosol. The automatic detection trigger device for the quantitative compressed administration aerosol includes a main machine body, wherein the main machine body consists of a main machine front cover, a main machine rear cover, a battery module and a driving assembly; the driving assembly includes a driving control module and a driving gear module; a charging port is formed at an outer side of the main machine front cover; a limiting pedestal is clamped at a bottom end of the main machine front cover; and an aerosol medicine is fixedly mounted at the bottom of an inner cavity of the main machine front cover. The automatic detection trigger device for the quantitative compressed administration aerosol detects an inspiration flow rate of a user in a medicine inhaling process through a flow sensor arranged in the driving assembly. When the inspiration flow rate reaches an ideal threshold, the device drives the aerosol to spray a medicine, and the medicine sprayed by the aerosol enters a lower respiratory tract such as a lung along with airflow, so that the problem of hand-mouth synchronous operation is solved, and the utilization rate of the medicine is greatly increased.

Systems and methods are provided for aerosolizing and delivering therapeutic substances in an electronic aerosol delivery device with airflow regulation. Calibrated airflow resistance settings enable adjustment and control of flow velocity and or flow volume of air, aerosolized air, and or entrained aerosol particles, through the device, for optimal aerosol delivery among diverse conditions and applications.

An aerosol-generating system is provided, including a housing including an air inlet and an air outlet defining an air flow path therebetween; a heater element; and a cartridge moveably mounted in the housing and reversibly displaceable from a first position to a second position, the cartridge including a moveable plunger, a liquid storage portion configured to hold an aerosol-generating liquid, and an opening configured to deliver the aerosol-generating liquid, wherein the cartridge is further configured to activate release of a portion of the aerosol-generating liquid through the opening, when the cartridge is moved by an airstream created between the air inlet and the air outlet within the housing.

An inhaler, preferably for insertion into a nostril, in particular a horse's nostril, with a pressure generator, which has a tensioning device for the drive, and with a tensioning mechanism for tensioning the tensioning device, whereby the tensioning mechanism has a lever gear for tensioning the tensioning device.