A medication injection pen, including a housing, a dose set knob (DSK) comprising an internal key, and a dose stop member engaging the dose set knob. Rotation of the dose set knob to set a medication dose causes rotation of the dose stop member with respect to the dose set knob, and when the dose set knob is rotated to a last dose setting position, the dose stop member rotationally abuts the internal key thereby preventing further rotational movement of the dose set knob in a dose setting direction.

An adjustable dosage limiting device includes a member that interfaces to a plunger flange of a syringe and a barrel loop that slides along a barrel of the syringe. A locking mechanism, when engaged, fixes a distance between the member that interfaces to a plunger flange and the barrel loop, and hence, locks the barrel loop in place with respect to the plunger flange. Once locked in place, the adjustable dosage limiting device limits a dosage provided by the syringe based upon a distance between the member that interfaces to a plunger flange and the barrel loop as set by the locking mechanism.

An injection device for injecting medicament in a patient comprises a housing configured to house a fluid reservoir that has one of a plurality of volumes of medicament. An injection conduit fluidly coupled to the fluid reservoir defines a fluid pathway from the fluid reservoir to the patient. A firing mechanism is coupled to the fluid reservoir and is configured to expel the medicament from the fluid reservoir through the injection conduit. A volume setting mechanism is coupled to the firing mechanism and is configured to select the one of the plurality of volumes of medicament for the firing mechanism to expel. A dose setting mechanism is configured to select all or a fraction of the one of the plurality of volumes of medicament that is injected from the injection conduit when the firing mechanism is actuated.

A dosing syringe comprising a barrel and a piston is provided. The piston is slidably receivable in the barrel and can move within the barrel from a maximum inserted position to a withdrawn position to draw a dose of a product into the barrel. The syringe comprises means for pre-setting the withdrawn position, which defines a maximum dose which can be drawn into the barrel.

A drug delivery device includes a housing and a movable member, which is arranged to be rotatable in an incrementing direction and a decrementing direction, the movable member being operatively coupled to an energy storage member and biased to rotate into the decrementing direction by energy stored or storable in the energy storage member. Rotation of the movable member in the incrementing direction increases the energy stored in the energy storage member. The drug delivery device also includes a locking system including a locking feature, a block feature, and a release member, wherein the locking feature is arranged to cooperate with the block feature to form a releasable locking interface configured such that, when the releasable locking interface is established, rotational movement of the movable member relative to the housing is blocked in the decrementing direction, and when the releasable locking interface is released, the movable member is rotatable in the decrementing direction.

The present invention provides a piston rod displacement mechanism for a pen injection device, comprising: a tubular housing (2) extending along a reference axis and comprising an interior housing surface (3) with a first engagement structure (4), a nut member (5) fixed within the tubular housing (2), a piston rod (15) comprising a first non-self-locking thread (18) having a first thread direction and a first thread pitch and being engaged with the nut member (5), and a second non-self-locking thread (17) superposed on the first non-self-locking thread (18), the second non-self-locking thread (17) having a second thread direction and a second thread pitch, and a dose dial sleeve (20) operable to advance the piston rod (15) in the nut member (5), the dose dial sleeve (20) comprising an exterior sleeve surface (21) with a second engagement structure (24) being in sliding engagement with the first engagement structure (4), and an interior sleeve surface (23) with a third engagement structure (29) being engaged with the second non-self-locking thread (17). One of the first engagement structure (4) and the second engagement structure (24) comprises a closed-circuit track configuration and the other of the first engagement structure and the second engagement structure comprises a track follower, and the closed-circuit track configuration comprises a helical track portion (24h) having a helical track direction equaling the second thread direction and a helical track pitch equaling the second thread pitch, and an axial track portion (24a) extending between a distal track end (24d) and a proximal track end (24p) and being connected to the helical track portion (24h) at the distal track end (24d).

A medicament delivery device for a mixing process to create a therapeutic substance for delivery within a multi-chambered cartridge, the delivery device includes a distal part with a dose setting mechanism having a housing, a dose setting knob, an injection button, a piston rod capable of moving axially along the longitudinal axis of the housing during dose delivery, and a return ring configured to reset the piston rod to a starting position. The delivery device also includes a proximal part including a cartridge holder configured to accept a multi-chambered cartridge, the cartridge holder including a screw driven sleeve configured for attachment to the distal part and rotation of the screw driven sleeve performing a medicament mixing process within the multi-chambered cartridge.

An injection device includes: a housing with a product container in which a stopper with a bearing face can be moved to a stopper end position and which, proximally to the stopper end position, has a minimum product container cross section; a drive configured to move the stopper, which includes a plunger rod with a drive face that contacts the bearing face; a plunger rod guide is arranged outside the product container and guides the plunger rod, with a plunger rod guide cross section adapted to a plunger rod cross section. The product container only incompletely guides movement of the plunger rod and the plunger rod cross section is not prevented from moving in a tilting direction by the minimum product container cross section, and a plunger rod centering aid a distal end of the plunger rod limits the movement of the plunger rod in the tilting direction.

A dosing syringe including a hollow cylindrical body and a plunger slidable within the hollow cylindrical body. The dosing syringe includes at least one slider slidable within a distal flange of the hollow cylindrical body transversely to the hollow cylindrical body and at least one wall is formed in the plunger for abutting and blocking the slider during its sliding within the flange, wherein the at least one wall provides a mechanical stop which stops the stroke of the plunger at a predetermined volume of product to be aspirated and/or dispensed.

A dose setting mechanism for a medicament delivery device, which dose setting mechanism comprises, a tubular member 10 having a longitudinal track 18 of a predetermined length; a dose drum 40, coaxial with the tubular member 10, and being axially and rotationally movable relative to the tubular member 10; a stop member 90, axially movable but rotationally locked relative to the tubular member 10, and further being in an axially slaved connection with the dose drum 40; wherein said stop member 90 comprises a track follower 98 in engagement with the longitudinal track 18, such that rotational movement of the dose drum 40 relative to the tubular member 10 may cause a maximum axial displacement of said dose drum 40 and said stop member 90, relative to the tubular member 10, corresponding to said predetermined length.