A vascular access device may include a blood circuit having an arterial blood line and a venous blood line. The venous blood line is connected to a first access needle and the arterial blood line is connected to a second access needle. The venous blood line is connected to an access component affixed to the second access needle and configured such that when the second access needle is used to infuse blood into a patient, the access component is positioned to withdraw blood and convey it into the venous line. The withdrawn blood may also be conveyed to an air detector to detect withdrawal of the second access needle.

A syringe assembly includes a main part with a bottom part and a top part. A compressible portion is connected to the top part, and a press unit is formed to the top the compressible portion. A needle is fixed to the top part and located within the compressible portion. The tip of the needle is located corresponding to a film of the press unit. The bottom part has a first lip and a second lip formed to the inner periphery thereof. The top part has a first groove and a second groove in the outer periphery thereof. Multiple collars are telescopically connected to each other, and are connected between the top part and the bottom part. The main part is located in the multiple collars. Each collar has two engaging portions which form two engaging grooves to be engaged with each other when collapsing the collars.

An insertion assembly and method of manufacturing an insertion assembly. The method includes forming a catheter assembly including a catheter hub and a catheter, inserting a needle into the catheter assembly such that a distal tip of the needle extends distal of a distal end of the catheter, and permanently adhering an interface pad to the catheter hub. The interface pad can include a foam material including a haemostatic agent. The haemostatic agent can include microdispersed oxidized cellulose. The foam material can further include an antimicrobial agent such as chlorhexidine gluconate.

A needle assembly to prevent fluid/vapor escape so as to reduce or prevent fluid exposure to a clinician during use of the needle assembly. The needle assembly may include a handle portion with a needle extending therefrom, and a base portion releasably coupled to the handle portion. The base portion may include a safety assembly to shield a distal tip of the needle and prevent user contact therewith. The base portion may further include a self-sealing pad covering a bottom external surface thereof. The self-sealing pad may include an upper surface designed to mate with the base portion and a raised portion compressively positioned in the opening of the bottom external surface. The needle assembly may further include a fluid isolation component.

The disclosed compositions, methods, and devices are useful in freezing, storing, and administering therapeutic eukaryotic cells to a patient in need thereof. In many embodiments, the disclosed therapeutic cells are mammalian cells derived from human intervertebral disc tissue. The disclosed compositions, methods, and devices are able to maintain high viability and sterility of the therapeutic cells, and allow the cells to be administered to a patient directly from the freezing container without manipulation of the cells or transferring to a second container.

An insertion assembly and method of manufacturing an insertion assembly. The method includes forming a catheter assembly including a catheter hub and a catheter, inserting a needle into the catheter assembly such that a distal tip of the needle extends distal of a distal end of the catheter, and permanently adhering an interface pad to the catheter hub. The interface pad can include a foam material including a haemostatic agent. The haemostatic agent can include microdispersed oxidized cellulose. The foam material can further include an antimicrobial agent such as chlorhexidine gluconate.

A vascular access device may include a blood circuit having an arterial blood line and a venous blood line. The venous blood line is connected to a first access needle and the arterial blood line is connected to a second access needle. The venous blood line is connected to an access component affixed to the second access needle and configured such that when the second access needle is used to infuse blood into a patient, the access component is positioned to withdraw blood and convey it into the venous line. The withdrawn blood may also be conveyed to an air detector to detect withdrawal of the second access needle.

Devices for protecting a user from a sharp tip of a medical needle includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion. The medical needle includes a longitudinal axis that is substantially perpendicular to at least one of a long axis of the central body portion and the delivery tube. The pair of wings are selectively positionable in a first position in which the pair of wings are spaced apart from the medical needle and a second position in which the pair of wings are proximate the medical needle. A mechanical fastener is disposed on at least one of the pair of wings, the mechanical fastener configured to selectively attach the pair of wings together in the second position with the medical needle positioned therebetween. Methods of using the device including administering medicinal fluids.

Devices for protecting a user from a sharp tip of a medical needle includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion. The medical needle includes a longitudinal axis that is substantially perpendicular to at least one of a long axis of the central body portion and the delivery tube. The pair of wings are selectively positionable in a first position in which the pair of wings are spaced apart from the medical needle and a second position in which the pair of wings are proximate the medical needle. A mechanical fastener is disposed on at least one of the pair of wings, the mechanical fastener configured to selectively attach the pair of wings together in the second position with the medical needle positioned therebetween. Methods of using the device including administering medicinal fluids.

A safety needle assembly of an infusion set is disclosed. The needle assembly is configured to prevent fluid/vapor escape therefrom so as to reduce or prevent fluid exposure to a clinician using the needle assembly. In one embodiment, the needle assembly comprises a handle portion including a needle extending therefrom, the needle defining a lumen for passage of a fluid therethrough. The needle assembly also includes a safety assembly defining a needle hole through which the needle initially extends. The safety assembly is selectively and axially slidable along the needle in order to shield a distal tip of the needle and prevent user contact therewith. A fluid isolation component is included in the safety assembly for isolating fluid escape from the needle. In another embodiment, an interface pad is included on the bottom of the needle assembly and includes an antimicrobial and/or haemostatic agent to protect the needle insertion site.