A plunger rod (104) for use in connection with a syringe barrel (102) is provided. The plunger rod (104) comprises a distal plunger top (105), having a proximal bottom surface (113), and a proximal elongated shaft (106) comprising a proximal end (107a) adapted to receive an applied force along an axis (1000) and a distal end plate (107b) adapted to transmit said applied force along said axis (1000). The plunger rod (104) is adapted to be inserted into the barrel (102) of a syringe (100) extending along the axis (1000). The distal plunger top (105) and the proximal elongated shaft (106) are connected to each other by a releasable connection (115). The releasable connection (115) comprises: distal top rupture means (116) comprising at least one distal top rib (125a) disposed eccentrically from the axis (1000) on the proximal bottom surface (113), and proximal shaft rupture means (117) comprising at least one proximal shaft rib (125b) disposed eccentrically from the axis (1000) on the distal end plate (107b). Each said at least one distal top rib (125a) is connected to a corresponding at least one proximal shaft rib (125b), said ribs (125a, 125b) being connected at a contact area (118), and wherein said distal top rupture means (116) is configured to detach from the proximal shaft rupture means (117) due to compression failure when the distal plunger top (105) is pushed into a distal end (110) of the barrel (102). A syringe is also provided.

Disclosed is a method of sealing a syringe barrel having a syringe tip with a collar. The syringe tip is sealed with a resilient closure. A tamper evident syringe tip cap comprising a cap member and a sleeve member separated by an annular first breaking line is then pushed over the resilient closure, to couple the proximal end of the sleeve member with the collar. The distal end of the resilient closure is accommodated in the cap member and protrudes beyond the sleeve member. The first breaking line is bridged by a coupling strip. For use of the syringe and providing access to the closure, the first breaking line is broken by pivoting the cap member away. The sleeve member remains coupled to the collar. Further tearing the cap member downward causes breaking a second breaking line provided in the sleeve member, thereby enabling removing the entire syringe tip cap.

A syringe with structural features to accomplish one-handed aspiration as well as one-handed injection. The syringe includes one or more breaking points that are configured to break at predetermined locations in response to external forces being applied thereto. To assist in accountability, identification chips and/or codes are included to allow for the traceability of the syringe to potential sources of irresponsible dispensing of medical waste.

The invention provides a syringe assembly comprising a syringe barrel having an inside surface defining a chamber, an open proximal end, and a distal end having an opening therethrough. An elongated plunger rod extends between a first end and a second end, with a cap or guard disposed on the first end of the plunger rod. A plunger head extends within the chamber of the syringe barrel, and is adapted for slidable movement within the syringe barrel between the proximal end and the distal end, with the second end of the plunger rod connected with the plunger head through a pivotable connection. The plunger rod is adapted to pivot with respect to the plunger head between a first position in which the guard is adjacent the distal end of the syringe barrel and a second position in which the plunger rod is in general axial alignment with the syringe barrel, and is further adapted for axial movement so as to cause sliding movement of the plunger head through the syringe barrel to expel contents thereof.

An automatic mixing device, an actuating device removably mounted to the automatic mixing device and a retractable syringe having the automatic mixing device are provided. The actuating device has an initially compressed spring and a trigger member that initiates spring decompression to drive depression of a mixing plunger of the automatic mixing device. A seal located in the outer chamber is capable of axial movement upon depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in an inner barrel to a second position intermediate the apertures and vents in an outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in an inner chamber of the inner barrel. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.

An injection device is described. The injection device includes a stopper having a first conductive element, a barrel having a medicament reservoir sealed at a proximal end with the stopper, and a plunger rod having a second conductive element. The plunger rod is coupled with the stopper to cause forward axial movement of the stopper to expel a medicament from the medicament reservoir. The first conductive element and the second conductive element complete an electrical circuit when the plunger rod is coupled to the stopper.

A syringe can comprise a syringe barrel; a syringe plunger; and a syringe seal. The syringe plunger can comprise a plunger body spanning between a plunger proximal end and a plunger distal end, wherein the syringe plunger can be disposed in the syringe barrel such that the plunger proximal end is disposed within the syringe barrel and the plunger distal end is outside the syringe barrel. The syringe seal can comprise and span between a seal first end and a seal second end, wherein the seal first end can be coupled to the syringe barrel and the seal second end can be coupled to the syringe plunger.

An injection device including a barrel having a medicament reservoir therein capable of fluid communication with a needle assembly at a distal end thereof and sealed at a proximal end thereof with a stopper. The injection device further includes a plunger rod having a distal rod end which is couplable with said stopper, wherein, when the plunger rod is coupled to the stopper, forward axial movement of the plunger rod causes forward axial movement of the stopper coupled thereto into the medicament reservoir in order to expel medicament through the needle assembly. Further, the plunger rod can be decoupled from the stopper by applying a rearward axial force on the plunger rod, said rearward axial decoupling force being less than a rearward axial force required to move the stopper rearwardly with respect to the barrel.

A syringe (100) comprising a barrel (111) with a lumen is provided. The barrel (111) is adapted to contain a drug, the barrel (111) having a distal end wall portion (198) and a tubular wall (112) extending proximally from said distal end wall portion (198), whereby the barrel (111) extends along an axis (1000). The distal end wall portion (198) has an opening (199) extending into a syringe head (140) adapted to receive a syringe needle, said syringe head (140) having a lumen smaller in transversal cross-section than the barrel lumen; the syringe (100) further comprising: a plunger (196) extending along the axis, said plunger shaft being displaceable along the axis (1000) within said barrel (111).

A drug delivery device comprises a housing and a mechanical assembly, which is at least partially accommodated in the housing. The mechanical assembly comprises a predetermined breaking member, which is configured to be damaged when forcefully separated from the housing.